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Gastrodia elata chewing gum agent, preparation method and detection method thereof

A detection method and chewing gum technology, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of inevitable liver first-pass effect, influence on bioavailability, and increase of adverse reactions, so as to avoid first-pass effect, improve bioavailability, and reduce adverse reactions Effect

Inactive Publication Date: 2012-01-11
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Gastrodia elata products currently on the market include conventional preparations such as whole Gastrodia elata capsules and Gastrodia elata tablets, but there are the following problems: (1) slow onset
This disadvantage is especially unsuitable for the treatment of headaches, migraines, allergies, nausea, indigestion, colds and coughs, motion sickness and certain acute conditions
(2) Inconvenient to take
Conventional preparations need to be taken with water, not suitable for children, the elderly who have difficulty swallowing tablets, and patients with nausea
(3) Adverse reactions
Since the drug is mainly absorbed through the gastrointestinal tract, the first-pass effect of the liver is inevitable, which affects the bioavailability. In order to achieve the effect, it is necessary to increase the dosage of similar drug preparations, which increases the possibility of adverse reactions.

Method used

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  • Gastrodia elata chewing gum agent, preparation method and detection method thereof
  • Gastrodia elata chewing gum agent, preparation method and detection method thereof
  • Gastrodia elata chewing gum agent, preparation method and detection method thereof

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Embodiment 1

[0043] Prepare the chewing gum of the composition ratio of the present invention: get Gastrodia elata powder (the Gastrodia elata is pulverized into powder and pass No. ) 16.5g, essence 1g, wetting agent 25g, sweetener 41g; essence, sweetener (mixture made of xylitol and kantame at 2:3) were passed through No. 9 sieve respectively and mixed with Gastrodia elata powder The gum base was softened in an oven at 60°C for 5 hours, and the Gastrodia elata powder mixed with the essence and sweetener, and the wetting agent (a mixture of glycerin and sorbitol with a concentration of 70% at a ratio of 1:1) were divided into three times. Add it into a mortar and mix it with the gum base, and when it cools down to about 40°C, put it into a noodle press and extrude it into a noodle press for aging. The aging temperature is 20°C, relative humidity below 55%, and the time is 10-12 hours. Cutting, packaging, that is, chewing gum. The moisture content of the chewing gum is less than or equal t...

Embodiment 2

[0045] Preparation of the chewing gum with the composition ratio of the present invention: decoct Gastrodia elata with water twice, add 12 times the amount of water for the first time, soak for 1.0 hour, and decoct for 2 hours; add 10 times the amount of water for the second time, decoct for 2 hours , combined the decoction, filtered, and the filtrate was centrifuged at high speed, and the centrifuged liquid was concentrated under reduced pressure to a medicinal solution with a relative density of about 1.10 (60° C.), sprayed and dried, and passed through a No. 9 sieve to form gastrodia elata powder; Gum base 16.5g, essence 1g, wetting agent 25g, sweetener 41g; Essence and sweetener (mixture made of xylitol and kagonin at a ratio of 1:2) were also passed through a No. 9 sieve and mixed with Gastrodia elata powder Mix well; the gum base is softened in an oven at 60°C for 5 hours, and the Gastrodia elata powder mixed with the essence and sweetener, and the wetting agent (a mixtur...

Embodiment 3

[0047] Prepare the chewing gum of the present invention's composition ratio: get Gastrodia elata powder (made after ultrafine pulverization of Gastrodia elata) 12g, food grade gum base 12g, essence 0.5g, wetting agent 25.5g, sweetener 50g; and sweetener (xylitol) respectively passed through No. 9 sieve and mixed with gastrodia elata powder, the gum base was softened in an oven at 60°C for 5 hours, and the gastrodia elata powder, wetting agent ( Glycerin) is added in three times into the mortar and mixed with the gum base, and when cooled to about 40°C, it is put into a noodle press and extruded into a noodle press. After water balance and aging, it is cut and packaged to obtain chewing gum.

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Abstract

The present invention discloses a gastrodia elata chewing gum agent, a preparation method and a detection method thereof. The gastrodia elata chewing gum agent comprises: 12-20% of gastrodia elata powder, 12-20% of food-grade gum base, 0.5-1% of essence, 20-30% of a wetting agent, 30-50% of a sweeting agent. The gastrodia elata chewing gum agent provided by the present invention has advantages ofrapid onset, easy taking, easy carrying and storing due to small volume, unsusceptibility of microbial contamination due to small water content, xerostomia eliminating, light side effect and good release rate. The preparation method for the gum agent is easy to be operated. The prepared gastrodia elata chewing gum agent with the function of rapid drug release provides good application prospects for treating headache, migraine and other acute diseases. The invention further discloses the detection method for product quality control of the gastrodia elata chewing gum agent.

Description

technical field [0001] The invention relates to traditional Chinese medicine preparations, in particular to the technical field of preparation of chewing gum for acute diseases such as headache and migraine. Background technique [0002] Gastrodia elata is the dry tuber of Gastrodia elata BL., the ancient name of Chijian. It is mainly produced in Yunnan, Guizhou, Sichuan, Shaanxi and other places in my country. It is one of the commonly used precious Chinese medicinal materials in China. It has the effects of calming the liver and subduing yang, relieving wind and spasm, dispelling wind and dredging collaterals. It is mainly used for limb numbness, headache, dizziness, convulsions in children, convulsions, epilepsy, tetanus and other diseases. [0003] Gastrodia elata products in the market have conventional preparations such as whole gastrodia elata capsules, gastrodia elata tablets, but there are the following problems: (1) slow onset. After oral administration of conven...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K31/7034A61K31/715A61K9/68G01N30/02A61P25/04A61P25/06
Inventor 万军周霞
Owner SOUTHWEST JIAOTONG UNIV
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