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Monascus compound preparation capable of regulating pressure and lipid and improving arteriosclerosis, coronary heart disease and cerebral embolism

A technology for arteriosclerosis and coronary heart disease, which is applied in the field of compound preparations, can solve the problems of unfavorable patients such as long-term use and thorough rehabilitation treatment, decreased antioxidant capacity, and increased liver burden, achieving stable and reliable curative effect, improving arteriosclerosis, and low cost Effect

Active Publication Date: 2012-12-12
上海考门医药科技有限公司
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AI Technical Summary

Problems solved by technology

In fact, ordinary chemically synthesized statin drugs are not perfect. While effectively preventing and treating cardiovascular and cerebrovascular diseases, they also increase the burden on the liver, cause the increase of transaminases in the body, and reduce the antioxidant capacity. These are particularly unfavorable for long-term use by patients. Therefore, there is an urgent need for a product that has both the efficacy of statins and does not have the toxic side effects of statins to prevent and treat cardiovascular and cerebrovascular diseases

Method used

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Embodiment Construction

[0019] The present invention utilizes a natural monascus solid fermentation method to obtain high-purity monascus statin. The monascus of the present invention also contains the secondary metabolite lovastatin of monascus and other active ingredients.

[0020] Among them, natural statins can inhibit the synthesis of endogenous lipids, reduce the absorption of exogenous lipids, and at the same time increase the activity of high-density lipoproteins, and increase the transport and decomposition of lipids. A variety of unsaturated fatty acids can effectively reduce blood lipids, evacuate platelets, remove vascular waste, and inhibit the formation of thrombus. 18 kinds of amino acids and trace elements, strong anti-oxidation, improve immunity. Chinese herbal extracts improve blood vessel function, nourish the liver and produce essence. R-amino acid improves the relaxation ability of vascular endothelial cells, smoothly lowers blood pressure, and has a scientific mechanism for loweri...

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Abstract

The invention relates to a monascus compound preparation capable of regulating pressure and lipid and improving arteriosclerosis, coronary heart disease and cerebral embolism. The preparation is prepared through the following steps: fermenting ginseng and gingko leaves in a liquid state to obtain ginseng fermentation liquor and gingko fermentation liquor, culturing monascus 9901 bacterium or 9906strain in a liquid state, and adding water into the ginseng fermentation liquor, the gingko fermentation liquor and grains to prepare a solid-state culture medium; grafting and performing solid statefermentation to initially obtain a monascus strain; sterilizing malt juice or potato juice, sugar and agar to prepare a plate; grafting and culturing to prepare a pure monascus strain; preparing a strain enlarged culture fluid; grafting and performing strain enlarged culture; culturing in a shaker; performing sterilization grafting and culturing on the ginseng extract, the gingko extract and a solid fermentation nutrient solution; sterilizing, baking, crushing and uniformly mixing the fermented solid culture to obtain monascus fine powder; and preparing the preparation according to a corresponding preparation process of the preparation. The non-citrinin high-color value functional monascus produced by adopting a liquid-state fermentation technology in the invention has the advantages of low cost, edible safety, tiny toxic or side effect, stable and reliable curative effect and short course of treatment.

Description

Technical field [0001] The invention relates to a compound preparation capable of regulating blood pressure, regulating fat and improving arteriosclerosis, coronary heart disease and cerebral embolism. Background technique [0002] Since the first chemically synthesized statin was approved by the US FDA in 1987, statins have triggered a revolution in the field of cardiovascular and cerebrovascular prevention, and statins have become the most effective drug in the treatment of cardiovascular and cerebrovascular. However, even today when statins are widely used, there are still 15 million deaths from cardiovascular and cerebrovascular diseases in the world. In fact, ordinary chemical synthetic statin drugs are not perfect. They can effectively prevent and treat cardiovascular and cerebrovascular diseases. At the same time, they also increase the burden on the liver, cause the increase of transaminase in the body and decrease the antioxidant capacity. These are particularly unfavora...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14A61K36/258A61P9/10A61P9/12A61P3/06C12R1/645
Inventor 傅磊童纯宁王宏伟刘仲云
Owner 上海考门医药科技有限公司
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