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Monascus compound preparation capable of regulating pressure and lipid and improving arteriosclerosis, coronary heart disease and cerebral embolism

An arteriosclerosis, compound preparation technology, applied in cardiovascular system diseases, microorganism-based methods, biochemical equipment and methods, etc., can solve problems such as long-term use and complete rehabilitation treatment of unfavorable patients, reduced antioxidant capacity, and increased liver burden. , to achieve the effect of stable and reliable curative effect, improvement of arteriosclerosis and low cost

Active Publication Date: 2012-01-18
上海考门医药科技有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

In fact, ordinary chemically synthesized statin drugs are not perfect. While effectively preventing and treating cardiovascular and cerebrovascular diseases, they also increase the burden on the liver, cause the increase of transaminases in the body, and reduce the antioxidant capacity. These are particularly unfavorable for long-term use by patients. Therefore, there is an urgent need for a product that has both the efficacy of statins and does not have the toxic side effects of statins to prevent and treat cardiovascular and cerebrovascular diseases

Method used

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Embodiment Construction

[0019] The invention uses the natural monascus solid fermentation method to obtain high-purity monascus statin, and the invention also contains the secondary metabolite lovastatin of the monascus and other active ingredients.

[0020] Among them, natural statins can inhibit the synthesis of endogenous lipids, reduce the absorption of exogenous lipids, increase the activity of high-density lipoproteinase, and increase the transport and decomposition of lipids. A variety of unsaturated fatty acids can effectively reduce blood lipid levels, evacuate platelets, remove vascular garbage, and inhibit the formation of thrombus. 18 kinds of amino acids and trace elements, strong anti-oxidation, improve immunity. Extracts of traditional Chinese medicine, improve blood vessel function, nourish liver and generate essence. R-amino acid, improve the relaxation ability of vascular endothelial cells, stably lower blood pressure, and the mechanism of blood pressure lowering is scientific.

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Abstract

The invention relates to a monascus compound preparation capable of regulating pressure and lipid and improving arteriosclerosis, coronary heart disease and cerebral embolism. The preparation is prepared through the following steps: fermenting ginseng and gingko leaves in a liquid state to obtain ginseng fermentation liquor and gingko fermentation liquor, culturing monascus 9901 bacterium or 9906strain in a liquid state, and adding water into the ginseng fermentation liquor, the gingko fermentation liquor and grains to prepare a solid-state culture medium; grafting and performing solid statefermentation to initially obtain a monascus strain; sterilizing malt juice or potato juice, sugar and agar to prepare a plate; grafting and culturing to prepare a pure monascus strain; preparing a strain enlarged culture fluid; grafting and performing strain enlarged culture; culturing in a shaker; performing sterilization grafting and culturing on the ginseng extract, the gingko extract and a solid fermentation nutrient solution; sterilizing, baking, crushing and uniformly mixing the fermented solid culture to obtain monascus fine powder; and preparing the preparation according to a corresponding preparation process of the preparation. The non-citrinin high-color value functional monascus produced by adopting a liquid-state fermentation technology in the invention has the advantages of low cost, edible safety, tiny toxic or side effect, stable and reliable curative effect and short course of treatment.

Description

technical field [0001] The invention relates to a compound preparation capable of regulating blood pressure, regulating fat, and improving arteriosclerosis, coronary heart disease and cerebral embolism. Background technique [0002] Since the first chemically synthesized statin drug was approved by the US FDA in 1987, statin drugs have triggered a revolution in the field of cardiovascular and cerebrovascular prevention and treatment. Statins have become the most effective drugs in cardiovascular and cerebrovascular treatment. However, even today when statins are widely used, 15 million people around the world still die of cardiovascular and cerebrovascular diseases. In fact, ordinary chemically synthesized statin drugs are not perfect. While effectively preventing and treating cardiovascular and cerebrovascular diseases, they also increase the burden on the liver, cause the increase of transaminases in the body, and reduce the antioxidant capacity. These are particularly unf...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P9/10A61P9/12A61P3/06C12N1/14C12R1/645
Inventor 傅磊童纯宁王宏伟刘仲云
Owner 上海考门医药科技有限公司
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