Rna virus infection inhibitor, method for inhibition of infection by rna virus, products for inhibition of infection by rna virus, and use as rna virus infection inhibitor

一种RNA病毒、抑制剂的技术，应用在作为RNA病毒感染抑制剂领域，能够解决难以适用、抗病毒性降低、着色或抗病毒性不充分等问题

Inactive Publication Date: 2012-05-16
SEKISUI CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the quaternary ammonium group contained in the product disclosed in Patent Document 1 is a cationic group, and when it is included in a fiber such as rayon, a surfactant or the like must coexist. As a result, there is a problem that the antiviral property is lowered.
[0006] The water-insoluble aromatic hydroxy compound having a phenolic hydroxyl group disclosed in Patent Document 2 has the problem of coloring or insufficient antiviral properties when treating white fibers
[0007] The citric acid used in Patent Document 3 has weak resistance to repeated washing, and there is a problem that the antiviral property decreases due to washing
In addition, in the case of polyoxyethylene(dimethylimino)ethylene(dimethylimino)ethylene dichloride used in Patent Document 4, since halogen has skin irritation, its presence Difficult to apply to frequently worn clothes etc.

Method used

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  • Rna virus infection inhibitor, method for inhibition of infection by rna virus, products for inhibition of infection by rna virus, and use as rna virus infection inhibitor
  • Rna virus infection inhibitor, method for inhibition of infection by rna virus, products for inhibition of infection by rna virus, and use as rna virus infection inhibitor
  • Rna virus infection inhibitor, method for inhibition of infection by rna virus, products for inhibition of infection by rna virus, and use as rna virus infection inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] An aqueous solution of sodium p-styrenesulfonate homopolymer (manufactured by Tosoh Organic Chemicals Co., Ltd., trade name "PS-1"), content of sodium p-styrenesulfonate homopolymer as a compound that inhibits RNA virus infection: 20% by weight , weight-average molecular weight (Mw): 25,000, Z-average molecular weight (Mz): 49,000) 20 parts by weight were added to 80 parts by weight of phosphate-buffered saline (Phospate-Buffered Saline; hereinafter referred to as "PBS"), and mixed uniformly, An RNA virus infection inhibitor solution was obtained. It should be noted that the sodium p-styrenesulfonate homopolymer is water-soluble. The ratio of the sulfonic acid group forming the sodium salt in the sodium p-styrene sulfonate homopolymer is 100 mol%.

Embodiment 2

[0127] The RNA virus infection inhibitor solution was obtained in the same manner as in Example 1, except that an aqueous solution of sodium p-styrenesulfonate homopolymer (manufactured by Tosoh Organic Chemicals Co., Ltd., commercial product) as a compound that inhibits RNA virus infection was used. Name "PS-50", sodium p-styrenesulfonate homopolymer content: 20% by weight, weight average molecular weight (Mw): 390,000, Z average molecular weight (Mz): 618,000) 20 parts by weight. It should be noted that the sodium p-styrenesulfonate homopolymer is water-soluble. The ratio of the sulfonic acid group forming the sodium salt in the sodium p-styrene sulfonate homopolymer is 100 mol%.

Embodiment 3

[0129] The RNA virus infection inhibitor solution was obtained in the same manner as in Example 1, except that an aqueous solution of sodium p-styrenesulfonate homopolymer (manufactured by Tosoh Organic Chemicals Co., Ltd., commercial product) as a compound that inhibits RNA virus infection was used. Name "PS-100", sodium p-styrenesulfonate homopolymer content: 20% by weight, weight average molecular weight (Mw): 529,000, Z average molecular weight (Mz): 758,000) 20 parts by weight. It should be noted that the sodium p-styrenesulfonate homopolymer is water-soluble. The ratio of the sulfonic acid group forming the sodium salt in the sodium p-styrene sulfonate homopolymer is 100 mol%.

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PUM

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Abstract

Disclosed is an RNA infection inhibitor which can inhibit the infection of a human by an RNA virus effectively to prevent the development of a morbid condition or alleviate the morbid condition even when the morbid condition has been developed and which rarely undergoes unexpected discoloration or discoloration under the ordinary conditions of use. The RNA virus infection inhibitor is characterized by comprising an RNA virus infection-inhibiting compound composed of a linear polymer and at least one substituent having a structure represented by any one of general formulae (1) to (3) (wherein at least one of substituents R1 to R5, at least one of substituents R6 to R12 and at least one of substituents R13 to R19 represents a carboxy group, a sulfonic acid group, or a salt or derivative thereof) attached to a side chain of the linear polymer.

Description

technical field [0001] The present invention relates to an RNA virus infection inhibitor, a method for inhibiting RNA virus infection, an RNA virus infection inhibiting product obtained by treating an RNA virus target object with an RNA virus infection inhibitor, and use as an RNA virus infection inhibitor. Background technique [0002] In recent years, due to the prevalence of seasonal influenza virus and the mutation of highly pathogenic avian influenza virus to infect people, it may cause a worldwide epidemic. [0003] In addition, there is still a hidden danger of reproducing the SARS virus with a very high lethality rate, and the sense of panic about highly pathogenic RNA viruses is getting stronger and stronger. In response to these problems, for example, Patent Document 1 discloses a product for inactivating viruses by contact, the product comprising a cloth (cloth) coated with an immobilized polymer, which is endowed with a non-permeable The antiviral activity is sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/795A61K31/765A61P31/14A61P31/16
CPCA61K31/765A61P31/14A61P31/16A61K31/795
Inventor 赤峰隆之藤原昭彦铃木太郎
Owner SEKISUI CHEM CO LTD
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