Method and apparatus of determining exhaled nitric oxide

A technology of nitric oxide, devices, applied in children's field, can solve the problem of increasing complexity

Inactive Publication Date: 2012-05-23
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, this method requires the subject to maintain a series of different constant flow rates, thus increasing the complexity of performing the test
Another difficulty with these alternative procedures is that the results cannot be easily compared with current standardized methods

Method used

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  • Method and apparatus of determining exhaled nitric oxide
  • Method and apparatus of determining exhaled nitric oxide
  • Method and apparatus of determining exhaled nitric oxide

Examples

Experimental program
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Embodiment Construction

[0069] Figure 1a A first embodiment of the invention is illustrated. The subject under test inhales and exhales via the interface 2 . The interface may be a standard interface used in current NO measurement equipment. During inhalation, a valve in the mouthpiece only allows flow along the inspiratory channel 4, with air drawn in via a NO filter 6 to remove nitric oxide from the inhaled air. Next, the subject exhales through the exhalation channel 8 . It will be noted that the exhalation channel 8 has no flow restricting element associated therewith, and there is no hindrance to exhalation other than the minimal restriction provided by the exhalation channel.

[0070] A NO analyzer 12, such as a known chemiluminescent NO analyzer, receives at least some of the exhaled air and measures the NO concentration during that exhalation. Analyzer 12 may also be based on a fast-response electrochemical NO sensor or NO-to-NO 2 Converter and photoacoustic NO 2 combination of sensors....

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PUM

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Abstract

A method and apparatus of determining the level of exhaled nitric oxide (NO) is disclosed. The method involves measuring the level of exhaled NO (34) and the corresponding exhalation flow rate in one or more exhalations (30, 32) of a tidal breathing manoeuvre performed by a subject. The data is used with a model describing the flow dependence of exhaled NO to derive a value for exhaled NO corresponding to a fixed flow rate, especially to an exhaled NO level corresponding to a fixed flow rate of 50 ml / s. During the manoeuvre a variation in flow restriction (31) may be applied so as to vary the overall flow rate of exhalation. The method offers a simple and quick way to determine exhaled NO levels with good accuracy and is suitable for use with children.

Description

technical field [0001] The present invention relates to methods and devices for determining nitric oxide production in the lungs based on tidal breathing manipulations, and in particular to methods and devices that are relatively quick and simple to perform or use and suitable for use in children. Background technique [0002] It is known that the concentration of nitric oxide (NO) in exhaled air can be used as an indicator of various pathological conditions. For example, the concentration of exhaled NO is a noninvasive marker of airway inflammation. Airway inflammation is often present in people with asthma, and monitoring of high concentrations of exhaled NO can be used in tests that can be useful in identifying asthma. Furthermore, the measurement of exhaled NO can be used to monitor the efficacy of inhaled corticosteroids in anti-inflammatory asthma management. [0003] Standardized methods for measuring exhaled NO require at least 5 cm H 2 At an overpressure of 0, pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/08G01N33/497
CPCA61B5/08A61B5/082
Inventor H·W·范克斯特伦T·J·温克N·P·威拉德
Owner KONINK PHILIPS ELECTRONICS NV
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