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Water-soluble film coated premix agent

A technology of film coating and premix, which is applied in drug delivery and pharmaceutical formulation, etc. It can solve the problems of difficult to meet high requirements, poor moisture-proof effect, etc., achieve uniform thickness, uniform coloring, and shorten coating time.

Active Publication Date: 2014-04-30
BEIJING YINGMAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface of water-soluble film coating is easier to absorb water and has poor moisture-proof effect, so it is difficult to meet the higher requirements of existing drugs

Method used

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  • Water-soluble film coated premix agent
  • Water-soluble film coated premix agent
  • Water-soluble film coated premix agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Present embodiment comprises following weight components:

[0025] Hydroxypropyl cellulose 500g;

[0026] Polyvinyl alcohol 70g;

[0027] Povidone K30 100g;

[0028] Polyethylene glycol 6000 120g;

[0029] Glyceryl triacetate 50g;

[0030] Talc powder 90g;

[0031] 600g of water;

[0032] Carmine 1g;

[0033] Carmine lake 30g;

[0034] Titanium dioxide 50g.

[0035] Mix the above amounts of hydroxypropyl cellulose, polyvinyl alcohol, povidone K30, polyethylene glycol 6000, titanium dioxide, glycerol triacetate, talcum powder, and water for 1 hour, dry at 40°C for 5 hours, and take the intermediate for detection , after passing the test, add carmine lake according to the above amount, mix for 0.5 hours, transfer to a grinder and grind for 5 hours, sieve, take the intermediate for testing, add the above amount of carmine to adjust, and mix for 1 hour. After the semi-finished product passes the inspection, pack , made of red film coating.

Embodiment 2

[0037] Present embodiment comprises following weight components:

[0038] Polyacrylic resin II 600g;

[0039] Polyvinyl alcohol 60g;

[0040] Povidone K30 80g;

[0041] Polyethylene glycol 6000 100g;

[0042] Glyceryl triacetate 10g;

[0043] Talc powder 100g;

[0044] 400g of water;

[0045] Lemon yellow 50g;

[0046] Lemon Yellow Aluminum Lake 10g;

[0047] Titanium dioxide 150g.

[0048] The preparation method of this embodiment is the same as that of Example 1.

Embodiment 3

[0050] Present embodiment comprises following weight components:

[0051] Microcrystalline cellulose 300g;

[0052] Methylcellulose 400g;

[0053] Polyvinyl alcohol 50g;

[0054] Povidone K30 120g;

[0055] Polyethylene glycol 6000 80g;

[0056] Glyceryl triacetate 100g;

[0057] Talc powder 90g;

[0058] 500g of water;

[0059] Bright blue 20g;

[0060] Brilliant blue aluminum lake 100g;

[0061] Titanium dioxide 100g.

[0062] The preparation method of this embodiment is the same as that of Example 1.

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Abstract

The invention relates to a water-soluble film coated premix agent, which comprises the following components: cellulose derivatives or acrylic acid derivatives, polyvinyl alcohol, povidone K30, polyethylene glycol 6000, glyceryl triacetate, talcpowder and water. According to the water-soluble film coated premix agent, a coated layer and medicinal tablets are combined firmly and closely, so that the tablets are uniform in coloring, and uniform in thickness and smooth; and the coated premix agent with different colors can be obtained by different ratios of titanium dioxide and a colorant, so that colorless and transparent coating, white coating and the colored coating can be obtained; and therefore, the appearance of medicines is improved. The polyvinyl alcohol is added into the water-soluble film coated premix agent, so the solid content of the film coated premix agent can be improved; and therefore, coating time is shortened.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a water-soluble film coating premix. Background technique [0002] With the continuous improvement of the pharmaceutical level, the continuous application of new pharmaceutical excipients and new technologies, drug coating has undergone the evolution from sugar coating to film coating. Film coating is a coating technology developed in the early 1950s. The film coating process can be widely used in tablets, pills, and granules, especially for traditional Chinese medicine tablets that are easy to absorb moisture, crack, and mottle. its superiority. Because film coating has the advantages of easy operation, short coating time, less weight gain, cost saving, good stability, and good moisture resistance, it has gradually replaced sugar coating. The film coating technology used in the pharmaceutical industry is a production process in which a small amount of safe, non-toxic and sta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K9/32
Inventor 陈佩英
Owner BEIJING YINGMAO PHARMA
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