Cefaclor composition particles and preparation method thereof

A technology of cefaclor and a composition, applied in the field of medicine, can solve problems such as poor dissolution rate, poor patient compliance, unfavorable swallowing, etc., and achieve the effects of enhancing antibacterial effect, improving drug dissolution rate, and avoiding drug agglomeration
CN102525949BActive Publication Date: 2013-06-05SHANDONG LUOXIN PHARMA GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG LUOXIN PHARMA GRP CO LTD
Publication Date
2013-06-05

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Abstract

The invention relates to the technical field of medicine, and discloses cefaclor composition particles and a preparation method thereof. The cefaclor composition particles disclosed by the invention are prepared from the following raw materials in parts by weight: 250 parts of cefaclor, 8 parts of bromhexine hydrochloride, 1,490 parts of sucrose, 20 parts of acesulfame, 2.5 parts of essence and 250 parts of sorbitol. The cefaclor composition particles disclosed by the invention comprise sorbitol which can be taken as a medicament dispersing agent for enhancing the medicament solubility and can be used for enhancing the antibacterial action of cefaclor. As proved by a test, the cefaclor composition particles disclosed by the invention have enhanced antibacterial action and high stability and can be widely applied to treatment of bacterial infection diseases such as respiratory tract infection, bone and joint infection, pelvic infection, abdominal infection and the like.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a cefaclor composition granule and a preparation method thereof. Background technique

[0002] Respiratory system infection is one of the most common infectious diseases clinically, such as acute and chronic respiratory infections, pneumonia, chronic obstructive pulmonary disease, and respiratory infections caused by colds. According to foreign statistics, the incidence of respiratory system infection accounts for more than 60% of the total incidence of various infectious diseases. In China, respiratory infection is the number one cause of death in rural areas, and it is also one of the four major killers in cities. Therefore, the treatment of respiratory system infection is a problem that is often faced clinically.

[0003] When a respiratory tract infection occurs, due to the inflammation of the respiratory tract, a large amount of mucus is secreted by the trachea, bronchial...

Claims

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