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Anti-osteoporosis Chinese medicinal preparation and preparation method thereof

An anti-osteoporosis and traditional Chinese medicine preparation technology is applied in the field of anti-osteoporosis traditional Chinese medicine preparations and preparations, traditional Chinese medicine compositions and preparation fields, and can solve problems such as side effects of deep vein thrombosis and achieve good prevention and treatment effects.

Active Publication Date: 2014-09-10
北京泰开尔营养科技发展有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, estrogen replacement therapy (HRT) has always been the first choice for postmenopausal osteoporosis, but its side effects in inducing reproductive system cancer and deep vein thrombosis have caused widespread controversy in the application of HRT

Method used

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  • Anti-osteoporosis Chinese medicinal preparation and preparation method thereof
  • Anti-osteoporosis Chinese medicinal preparation and preparation method thereof
  • Anti-osteoporosis Chinese medicinal preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prepare the anti-osteoporosis preparation, the method is as follows:

[0032] (1) Take 4 kg of Epimedium, 4 kg of Pueraria Radix, and 4 kg of Dipsacus, add 70% ethanol solution 5 times their total mass, reflux extraction twice, each time for 2 hours, filter, combine the extracts, and The extract is centrifuged, and the supernatant is passed through the D312 macroporous adsorption resin column, then the macroporous adsorption resin column is quickly rinsed with water, and then eluted with 70% ethanol solution, the ethanol eluate is collected, and the eluate is recovered into ethanol Concentrate to an appropriate amount and spray dry (inlet temperature 100°C) to obtain 2.1 kg of extract;

[0033] (2) Take 1 kg of deer horn gum and 0.1 kg of oyster, ultrafinely pulverize and pass through a 100-mesh sieve to obtain 1 kg of fine powder;

[0034] (3) Mix the extract and fine powder, add appropriate amount of conventional pharmaceutical excipients (starch, cyclodextrin, etc.)...

Embodiment 2

[0036] Prepare the anti-osteoporosis granule, the method is as follows:

[0037] (1) Take 6 kg of Epimedium, 6 kg of Pueraria Radix, and 6 kg of Dipsacus, add 6 times the amount of 50% ethanol solution, reflux and extract twice, each time for 3 hours, filter, combine the extracts, centrifuge the extracts, and take The supernatant is passed through the HPD100 type macroporous adsorption resin column, then the macroporous adsorption resin column is quickly washed with water, and then eluted with 50% ethanol solution, and the ethanol eluate is collected, and the eluate is recovered to ethanol and concentrated to an appropriate amount. Spray drying (inlet temperature 100°C) to obtain the extract;

[0038] (2) Take 3 kg of deer horn glue and 0.2 kg of oyster, ultrafinely pulverize and pass through a 100-mesh sieve to obtain fine powder;

[0039] (3) Mix the extract and fine powder, add appropriate amount of conventional pharmaceutical excipients, and make tablets, granules or caps...

Embodiment 3

[0041] Prepare the capsule of anti-osteoporosis, the method is as follows:

[0042] (1) Take 5 kg of Epimedium, 5 kg of Pueraria Radix, and 5 kg of Dipsacus, add 5 times the amount of 60% ethanol solution, reflux and extract twice, each time for 2 hours, filter, combine the extracts, and centrifuge the extracts. Take the supernatant to pass through the macroporous adsorption resin column, then quickly rinse the macroporous adsorption resin column with water, then elute with 60% ethanol solution, collect the ethanol eluate, recover ethanol from the eluate and concentrate to an appropriate amount, and carry out Spray drying (inlet temperature 120°C) to obtain the extract;

[0043] (2) Take 2 kg of deer horn glue and 0.1 kg of oyster; ultrafinely pulverize and pass through a 100-mesh sieve to obtain fine powder;

[0044] (3) Mix the extract and fine powder, add appropriate amount of conventional pharmaceutical excipients, and make capsules.

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Abstract

The invention discloses an anti-osteoporosis traditional Chinese medicine preparation, which is prepared from the following raw materials in parts by weight: 4-6 parts of epimedium, 4-6 parts of kudzu root, 4-6 parts of Dipsacus, and 1-3 parts of antler gum 0.1-0.2 servings of oysters. The invention also discloses a preparation method thereof, which is simple to operate and easy to implement. The present invention obtains a formula for treating postmenopausal osteoporosis according to the traditional theory of invigorating the kidney and strengthening the bones and the modern theory of plant isoflavones, and there is no relevant report on using the formula to treat osteoporosis in the prior art. The medicinal ingredients in the formula work synergistically, that is, to nourish the liver and kidney, strengthen the muscles and bones, and use plant isoflavones to replace the lack of estrogen in the body. The two-pronged approach has a good preventive effect on postmenopausal osteoporosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to an anti-osteoporosis traditional Chinese medicine preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a metabolic bone disease, which is a systemic bone disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fracture. Postmenopausal osteoporosis is a high-incidence disease in postmenopausal women. According to foreign statistics, the risk rate of osteoporosis in women over 60 years old is 58%. Postmenopausal osteoporosis is related to the decreased level of hormones synthesized by the ovaries, resulting in bone pain and fractures, seriously affecting the quality of life of women, and increasing the disability rate and mort...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/488A61K9/16A61K9/20A61K9/48A61P19/10
Inventor 李贵海吴晓文陆永辉孙付军
Owner 北京泰开尔营养科技发展有限责任公司
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