Gromwell pigment micro-capsules and preparation method thereof

A technique for shikonin and microcapsules, which is applied to the field of shikonin microcapsules and their preparation, can solve the problems of inability to achieve long-term effects and low content, and achieves alleviating bad odor, reducing irritation, and avoiding compatibility changes. Effect

Inactive Publication Date: 2012-07-18
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Comfrey, sweet, salty, cold, homecoming, liver meridian; function of clearing heat and cooling blood, promoting blood circulation and detoxification, penetrating rash and eliminating spots, has anti-oxidation, anti-cancer, anti-inflammatory and analgesic effects, and its main active ingredient is shikonin , the medicinal value is very high, but its content is low, and it is generally used as a compound preparation with other drugs in clinical practice, and due to the fat-soluble properties of shikonin, the absorption and metabolism in the body are too fast, and long-term effects cannot be achieved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Preparation of shikonin extract

[0021] Take 2000ml of petroleum ether with a boiling range of 60°C-90°C, add 200g of comfrey, heat to boil the petroleum ether and reflux to extract shikonin, extract for 2 hours, 3 times, recover the solvent from the petroleum ether extract of comfrey, The crude extract of shikonin was obtained, and its content was measured to be 57.8%.

[0022] Take 100g of silica gel and pack it into a column, dissolve 15g of shikonin crude extract with ethyl acetate, add silica gel to mix the sample, evaporate the ethyl acetate to dryness, pack the column, and wash with petroleum ether: ethyl acetate with a volume ratio of 20:1 Take off, combine the eluent and reclaim the solvent to obtain the shikonin extract, and the measured shikonin content is 64.4%;

[0023] (2) Preparation of microcapsules

[0024] Dissolve 80g of ethyl cellulose in 1200ml of dichloromethane, add 10g of shikonin extract and shake to dissolve, let stand for 30min,...

Embodiment 2

[0026] (1) Preparation of shikonin extract

[0027] Take 1500ml of petroleum ether with a boiling range of 60°C-90°C, add 200g of comfrey, heat to boil the petroleum ether and reflux to extract shikonin, extract for 2 hours, 5 times, recover the solvent from the petroleum ether extract of comfrey, The crude extract of shikonin was obtained, and its content was measured to be 57.9%.

[0028] Take 100g of silica gel and pack it into a column, dissolve 14g of shikonin crude extract in ethyl acetate, add silica gel to mix the sample, evaporate the ethyl acetate to dryness, pack the column, and wash with petroleum ether: ethyl acetate with a volume ratio of 20:1 Take off, combine the eluent and reclaim the solvent to obtain the shikonin extract, and the measured shikonin content is 64.6%;

[0029] (2) Preparation of microcapsules

[0030] Dissolve 100g of ethyl cellulose in 1000ml of dichloromethane, add 10g of shikonin extract and shake to dissolve, let stand for 30min, ...

Embodiment 3

[0032] (1) Preparation of shikonin extract

[0033] Take 2500ml of petroleum ether with a boiling range of 60°C-90°C, add 200g of comfrey, heat to boil the petroleum ether and reflux to extract shikonin, extract for 2 hours, 3 times, recover the solvent from the petroleum ether extract of comfrey, The crude extract of shikonin was obtained, and its content was measured to be 57.9%.

[0034] Take 100g of silica gel and pack it into a column, dissolve 17g of shikonin crude extract with ethyl acetate, add silica gel to mix the sample, evaporate the ethyl acetate to dryness, pack the column, and wash with petroleum ether: ethyl acetate with a volume ratio of 20:1 Take off, combine the eluent and reclaim the solvent to obtain the shikonin extract, and the measured shikonin content is 64.1%;

[0035] (2) Preparation of microcapsules

[0036] Dissolve 60g of ethyl cellulose in 800ml of dichloromethane, add 10g of shikonin extract and shake to dissolve, let stand for 30min, ...

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Abstract

The invention relates to gromwell pigment micro-capsules and a preparation method thereof. The preparation method comprises the following steps: totally dissolving 1 part by weight of ethyl cellulose into 4 to 30 parts by volume of dichloromethane; then adding extract of gromwell pigment and shaking to dissolve the extract of gromwell pigment; standing for 30 min; adding the obtained solution into 0.01 to 0.04 percent by mass of aqueous solution of sodium dodecyl sulfate with stirring; stirring for 2 h at a temperature of 10 to 30 DEG C; decompressing and carrying out pumping filtration; washing the obtained solid for three times by water; and after pumping, placing the obtained product into a drying box to dry so as to obtain the micro-capsules. According to the invention, the gromwell pigment micro-capsules and the preparation method thereof have the advantages that by carrying out microencapsulation after refining a medicament, the stability of the medicament is improved, the objectionable odor is reduced, the inactivation of the medicament in the gastrointestinal tract is prevented, the irritation of the medicament to the gastrointestinal tract is reduced, the release of the medicament is slowed down or controlled, the compatibility variation of the medicament is avoided, the medicament concentration is centralized to a target region, the biological activity of the medicament is stabilized, the gromwell pigment micro-capsules are beneficial for taking the curative effect and the like.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a shikonin microcapsule and a preparation method thereof. Background technique [0002] Comfrey, sweet, salty, cold, homecoming, liver meridian; function of clearing heat and cooling blood, promoting blood circulation and detoxification, penetrating rash and eliminating spots, has anti-oxidation, anti-cancer, anti-inflammatory and analgesic effects, and its main active ingredient is shikonin , the medicinal value is very high, but its content is low, and it is generally used as a compound preparation with other drugs in clinical practice, and due to the fat-soluble properties of shikonin, the absorption and metabolism in the body are too fast, and long-term effects cannot be achieved. Contents of the invention [0003] In order to solve the above-mentioned technical problems, the present invention uses the current preparation technology to make sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K36/30A61K47/38A61P39/06A61P35/00A61P29/00
Inventor 闫雪生徐新刚生立嵩于蓓蓓
Owner SHANDONG ACAD OF CHINESE MEDICINE
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