Extraction method for high-purity tetrodotoxin

A technology of tetrodotoxin and extraction method, which is applied in nervous system diseases, drug combination, organic chemistry, etc. It can solve the problems of cumbersome pre-treatment, difficulty in avoiding corruption of liquid medicine and medicine dregs, and difficulty in realizing industrialization, etc.
CN102584843AInactive Publication Date: 2012-07-18ηŽ‹η§€θŠ +2
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
ηŽ‹η§€θŠ
Publication Date
2012-07-18
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses an extraction method for high-purity tetrodotoxin, which is mainly used for extracting tetrodotoxin from animal feed puffer fish seeds and livers by jointly utilizing the methods of ultrasonic fast dissolving out, organic solvent derosination, plate frame multi-level filtration, positive ion exchange resin, small film filtration, high-performance liquid preparation and the like and obtaining high-purity high-stability tetrodotoxin crystals. Tetrodotoxin has the effect of blocking a sodium ion channel is obvious in analgesic effect and free of dependency and is widely used in advanced cancer, postoperative pain relieving, de-addiction curing of drug abuse and the like. Extraction and preparation of high-purity tetrodotoxin can provide the possibility of developing a novel high-efficiency pain killer free of dependency.
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Description

technical field

[0001] The invention relates to the technical field of marine organisms, and mainly relates to extracting high-purity monomer substances from animal raw materials, in particular to an extraction method for obtaining high-purity tetrodotoxin from puffer fish roe and liver. Background technique

[0002] Tetrodotoxin is a unique component of puffer fish, a marine migratory fish, and mainly exists in the ovary, liver and blood. Studies have shown that tetrodotoxin is also found in other fish, amphibians, mollusks, and echinoderms, such as tiger shrimp, blue-ringed octopus, California python, and even crustacean crabs. Tetrodotoxin is also known as round toxin, python toxin, oriental toxin and so on. Our country has a long history of studying tetrodotoxin, which was first recorded in "Shan Hai Jing", "Shen Nong's Materia Medica", "Kaibao Materia Medica", "Compendium of Materia Medica", etc. all have records about tetrodotoxin.

[0003] Since ancient times, tetro...

Claims

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