Nano emulsion for treating anaerobic infections of intestinal tracts of livestocks and preparation method of nano emulsion

Abstract

The invention discloses a nano emulsion for treating anaerobic infections of intestinal tracts of livestocks. The nano emulsion comprises the following raw materials in percent by mass: 0.1-8.0 percent of linaloe oil, 0.1-7.0 percent of carvacrol, 0.01-0.7 percent of metronidazole, 19.0-35.0 percent of surfactant, 0-5.0 percent of cosurfactant and the balance of distilled water, wherein the sum of the mass percent of the raw materials is 100 percent. The nano emulsion has stronger inhibiting and killing functions to most of obligate anaerobes, and is mainly used for treating enteritidis caused by infections of anaerobic bacteria such as bacteroides, clostridium, aerogenesis bacillus, peptococcus, eubacteria and streptococcus faecalis, for the livestocks. The nano emulsion has the advantages of high bioavailability, remarkable antibacterial action and treatment effect, and wide market prospect in the field of veterinary medicines.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, and relates to a medicine that can be used for enteritis caused by anaerobic bacteria infection in livestock and poultry, in particular to a nanoemulsion for treating intestinal anaerobic bacteria infection in livestock and poultry and a preparation method thereof. Background technique Anaerobic bacteria are a type of microbial flora that exist widely in nature and do not require oxygen to participate in their metabolic processes. Mainly include Gram-negative bacilli, Gram-positive cocci, Gram-negative cocci, etc. Anaerobic bacteria are the main flora in the intestinal tract of the body, accounting for more than 99% of the total number of bacteria. Under normal circumstances, due to the mutual restriction between different flora and the influence of the intestinal environment, they are generally in a mutualistic symbiotic state with the body. The body will not get sick, but when the body's ...

AI Technical Summary

Problems solved by technology

At present, the pharmaceutical dosage forms for the treatment of anaerobic infectious enteritis in livestock and poultry are mainly raw powder, powder and injection, but the raw powder and powder are prone to uneven stirring due to the small amount of mixing, and some raw powders are administered in drinking water. When the drug solubility is low or dissolves slowly, resulting in insufficient drug dosage or blockage of water diversion pipes for livestock and poultry, etc.

Injection is time-consuming and labor-intensive, and the animals are stressed, which is not conducive to large group operations. It is not as effective as oral administration in the treatment of gastrointestinal enteritis.

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