Compound clobetasol propionate and tretinoin ointment

A technology of clobetasol propionate and compound chlorine propionate, which is applied in the field of biomedicine, can solve the problems of unsatisfactory emulsification effects of oil phase matrix and alcohol phase matrix, and achieve excellent emulsifier, stable properties, and good content uniformity Effect

Active Publication Date: 2012-08-22
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Tween 80 is a hydrophilic emulsifier, and Span 60 is a lipophilic emulsifier, both of which are e

Method used

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Examples

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Embodiment 1- Embodiment 4

[0029] Example 1-Example 4: Preparation of Compound Clobetasol Propionate and Retinoic Acid Ointment

[0030] raw material Example 1 Example 2 Example 3 Example 4 Clobetasol Propionate 10 copies 10 copies 10 copies 10 copies Tretinoin 5 copies 5 copies 5 copies 5 copies stearyl alcohol 400 copies 800 copies 1000 copies 1400 copies Polysorbate 80 600 copies 600 copies 600 copies 600 copies Span 60 1500 copies 1500 copies 1500 copies 1500 copies Propyl gallate 40 copies 40 copies 40 copies 40 copies 2,6-di-tert-butyl-p-cresol 40 copies 40 copies 40 copies 40 copies Vitamin E 100 copies 100 copies 100 copies 100 copies citric acid 2 copies 2 copies 2 copies 2 copies liquid paraffin 2000 copies 2400 copies 2800 copies 3000 copies Absolute ethanol 1200 copies 1200 copies 1200 copies 1200 copies lanolin 1200 copies 1200...

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Abstract

The invention provides a compound clobetasol propionate and tretinoin ointment which comprises clobetasol propionate, tretinoin and octodecyl alcohol. The ointment can still keep a homogeneous system at high temperature of 40 DEG C, or even 60 DEG C, two-phase separation cannot occur, and the problem of uneven content of the preparation at high temperature can be effectively avoided. The ointmentis mainly used for treating psoriasis vulgaris, dermatitis, eczema, etc.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a compound clobetasol propionate and tretinoin ointment and a preparation method thereof, which are mainly used for treating diseases such as psoriasis vulgaris, dermatitis, and eczema. Background technique [0002] Both clobetasol propionate and retinoic acid are commonly used externally used drugs for treating skin diseases, and have definite curative effects. Clobetasol propionate (CP) is a powerful hormone, long-term use can cause side effects such as skin atrophy, and the common side effect of tretinoin use is skin irritation. In addition, transdermal absorption of drugs into the blood circulation system will produce systemic toxic and side effects. [0003] The applicant's patent application number 03100627.2 discloses a compound preparation of clobetasol propionate and retinoic acid. Through the combination of two kinds of drug compatibility preparations, clobetasol ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/06A61K47/44A61P17/00A61P17/06A61K31/203
Inventor 付劼周海滨张新明
Owner JIANGSU SEMPOLL PHARMA
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