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Novel use of aromatase inhibitors

A technology of aromatase inhibitors and preparations, which is applied in the direction of medical preparations containing active ingredients, urinary system diseases, organic active ingredients, etc. It can solve problems such as aromatase inhibitors that have not been reported yet, and achieve a significant effect of symptom relief

Inactive Publication Date: 2012-08-22
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] There are no reports on the use of aromatase inhibitors in relation to bladder outlet obstruction

Method used

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  • Novel use of aromatase inhibitors
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  • Novel use of aromatase inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: Preparation of mouse model

[0053] References: Molecular mechanisms of bladder outlet obstruction in transgenic male mice over expressing aromatase (Cyp19a1). LinW, Rahman NA, Lin J, Zhang H, Gou K, Yu W, Zhu D, Li N, Huhtaniemi I, Li X. Am J Pathol. 2011 Mar;178(3):1233-44. PMID: 21356374.

[0054] Experimental animals: C57BL / 6 mice were purchased from the Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army. C57BL / 6 is an inbred line imported from abroad. It is an inbred line produced by crossing B6F129 and B6JEiF78, and then 129 generations of sibling inbreeding. The related genotype is a / a.

[0055] Assay reagents: pUB6 / V5-HisA (Cat. No. V25020), purchased from Invitrogen, Carlsbad, CA; pRC / CMV (Cat. No. 10131027), purchased from Invitrogen, Carlsbad, CA.

[0056] C57BL / 6 mice were used to construct animal models of bladder outlet obstruction, and the specific methods were as follows:

[0057] 1. Constru...

Embodiment 2

[0226] Example 2: Effects of aromatase inhibitors on animal models of bladder outlet obstruction

[0227] 1. The preparation method of the model: refer to the method of Example 1 to construct the model, and screen the positive mouse model: cut the tail of the newborn mouse 15 days after birth, extract the genomic DNA, and screen out the positive aromatase overexpression mouse by PCR;

[0228] 2. Drugs:

[0229] The control group of positive mice, corn oil was purchased from sigma company;

[0230] Drug treatment group, letrozole (Letrozo1) was purchased from Novartis Pharmaceuticals Co., Ltd., Switzerland; Anastrozole was purchased from AstraZeneca Pharmaceuticals; and fenrozole was purchased from Hormos Pharmaceuticals, Finland.

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Abstract

The invention relates to a novel use of aromatase inhibitors, in particular to application of the aromatase inhibitors in terms of preparation of medicines for treating male bladder outlet obstruction and lower urethral syndromes caused by the same. The medicines can rapidly and effectively treat bladder outlet obstruction of male mice. The novel use can be clinically applied better, provides a fundamental basis for clinical treatment, and is a novel method for treating the bladder outlet obstruction.

Description

technical field [0001] The invention relates to medical applications, in particular to the application of an aromatase inhibitor in the preparation of medicines for preventing and treating male bladder outlet obstruction and the lower urinary tract syndrome caused by it. Background technique [0002] With the prolongation of human life span, the lower urinary tract (LUT) of elderly men has attracted more and more attention from the social and medical circles. [0003] Epidemiological surveys show that about 26% of men aged 40-49 have moderate and severe lower urinary tract syndrome (lower urinary tract syndrome, LUTS); about 46% of men aged 70 have LUTS. [0004] Epidemiological surveys in my country show that 1,583 male residents over 40 years old were selected from the general population in Shanghai, and the prevalence of LUTS in this population was investigated by methods such as International Prostate Symptom Score (IPSS) and Quality of Life (QoL) scores. rate and impact...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/4196A61P13/10A61P13/02
Inventor 李向东于万鹏林蔚张华
Owner CHINA AGRI UNIV
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