Topical pharmaceutical preparations having both a nanoparticle solution and a nanoparticle suspension and methods for the treatment of acute and chronic pain therewith

A nanoparticle, non-nanoparticle technology for the treatment of acute and chronic pain and inflammation that addresses acute pain and inflammation in undescribed topical formulations

Inactive Publication Date: 2012-10-03
阿布赛兹公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while these publications describe various techniques for producing nanoparticles and using these nanoparticles, for example, to make injections, they do not describe topical formulations or how topical formulations can be effectively used to treat acute pain and inflammation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027]LiNTEC nanosizing technology: solid particles of active pharmaceutical ingredients (such as NSAIDs and / or local anesthetics as described above) are dispersed in an aqueous solvent (such as water), vortexed and / or sonicated, with some particles going into solution , and some particles remain in solid form. Subsequently, solutions and suspensions of the active pharmaceutical ingredient are subjected to LiNTEC nanosizing technology by laser irradiation with irradiation of an appropriate wavelength according to the specific pharmaceutical agent used. The resulting formulations are solutions and nanoparticle suspensions of the active pharmaceutical ingredient, wherein the nanoparticle size ranges from 5 to 500 nm, preferably from 10 to 200 nm and most preferably from 20 to 100 nm. This formulation is then used in pharmaceutical formulations suitable for topical and / or transdermal delivery.

example 2

[0028] Example 2 (patch containing only piroxicam)

[0029] A transdermal patch was prepared for the treatment of acute and chronic pain and inflammation in humans with an adhesive material containing 60 mg of piroxicam nanoparticle suspension / solution prepared according to the procedure described in Example 1 in an aqueous base. It will be applied by the patient once a day, every 2 days, every 3 days, or every 5 to 7 days to the skin in areas that feel pain (eg, knees, shoulders, lower back). The patch may have 30 mg, 40 mg, 50 mg, 70 mg, 80 mg or 100 mg of piroxicam instead of 60 mg of piroxicam. The size of the patch can be 2cm×3cm, 3cm×4cm, 5cm×7cm, 7cm×10cm, 10cm×14cm, etc.

example 3

[0030] Example 3 (patch containing piroxicam and lidocaine)

[0031] Preparation of a transdermal patch for the treatment of acute and chronic pain and inflammation in humans with an adhesive adhesive containing 60 mg of piroxicam nanoparticle suspension / solution prepared according to the technique described in Example 1 and 900 mg of lidocaine in an aqueous base Material. It will be applied by the patient once a day, every 2 days, every 3 days, or every 5 to 7 days to the skin in areas that feel pain (eg, knees, shoulders, lower back). The patch may have any pharmaceutically suitable combination of 30mg, 40mg, 50mg, 70mg, 80mg or 100mg of piroxicam and 200mg, 300mg, 400mg, 500mg, 600mg, 700mg, 800mg, 1,000mg, 1,500mg or 2,000mg of lidocaine , instead of having 60mg piroxicam and 900mg lidocaine. The size of the patch can be 3cm×5cm, 5cm×7cm, 7cm×10cm, 10cm×14cm, etc.

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Abstract

This invention relates to topical pharmaceutical preparations and methods for the treatment of acute and chronic pain and inflammation therewith. The preparations have a saturated solution of an active pharmaceutical ingredient in a solvent therefor in intimate combination and contact with a suspension of nanoparticles of the active pharmaceutical ingredient in the solvent, and a pharmaceutically acceptable carrier therefor, and are administered topically.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 273,473, filed August 6, 2009, which is hereby incorporated by reference in its entirety, under 35 U.S.C. §119(e). technical field [0003] The present invention relates to topical pharmaceutical preparations. The invention also relates to methods of treating acute and chronic pain and inflammation with said topical pharmaceutical formulations. The formulations of the present invention consist of a saturated solution of an active pharmaceutical ingredient in a solvent used therefor and a suspension of nanoparticles of said active pharmaceutical ingredient in said solvent and a pharmaceutically acceptable pharmaceutical ingredient therefor suitable for topical administration. Accepted carriers are intimately combined and in contact. Background technique [0004] There are many ways in the art to prepare topical pharmaceutical formulations...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/10A61K9/06A61K45/00A61K45/06A61P29/00
CPCA61K9/7084A61K31/00A61K9/7038A61K31/192A61K31/5415A61K31/197A61K9/0014A61K9/06A61K9/14A61P15/00A61P19/00A61P19/02A61P19/06A61P23/02A61P25/06A61P29/00A61P5/24A61K31/167A61K31/407A61K45/06A61K2300/00
Inventor 王长金
Owner 阿布赛兹公司
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