Medicinal agent

A reagent, sodium chloride technology, applied in the field of pharmaceutical reagents, can solve the problem of not being able to stimulate cartilage metabolism

Inactive Publication Date: 2012-05-16
ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ИНСТИТУТ ГИАЛУАЛЬ"
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The disadvantage of the above drug is that the pre-filled syringe contains only one active ingredient - hyaluronic acid
The latter acts as an implant to provide a replacement, which contributes to the restoration of the balance of the synovial fluid in the cavity of the affected joint, but does not stimulate cartilage metabolism, nor does it act on the pathogenic link of various joint diseases (arthrosis, injury, etc.) comprehensive impact

Method used

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Examples

Experimental program
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Embodiment 1

[0028] drug composition

[0029]

Embodiment 2

[0031] drug composition

[0032]

Embodiment 3

[0034] drug composition

[0035]

[0036]

[0037] The drug was prepared by the following method.

[0038] The following components were used as raw materials:

[0039] - hyaluronic acid (sodium hyaluronate) (Pharm. Eur. 4, 01 / 2002: 1472, P. 1915);

[0040] - succinic acid (P.1228 USP 28);

[0041] - sodium chloride (State Pharmacopeia of Ukraine: 2004, Appendix 1, P.422);

[0042] - Sterile water (State Pharmacopeia of Ukraine: 2004, Appendix 1, P.307).

[0043] Fill the reservoir with the appropriate amount of sodium chloride, sodium succinate, succinic acid, dilute to the required amount with sterile water, and mix well. The calculated amount of hyaluronic acid was added to the resulting solution; it was stirred for 2 hours until a homogeneous mass was obtained.

[0044] Perform sample splitting and analysis; the pH of the solution should be between 5.0 and 8.5, and in 1 ml of the prepared solution, the quantitative content of the formulation components should co...

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Abstract

The invention relates to the chemical and pharmaceutical industry, more specifically to products for medical purposes and medicinal agents in the form of solutions and gels for intra-articular and intradermal administration, and can be used in orthopaedics, traumatology, arthrology, rheumatology and vertebrology as an agent for restoring the synovial balance in a joint cavity and for chondroprotection, as well as in dermatology, medical cosmetology and plastic surgery to delay the skin aging process. The medicinal agent comprises hyaluronic acid, sodium succinate, succinic acid, sodium chloride and water for injection in the following component ratio (g / l): 0.5-60.0 hyaluronic acid; 1.0-40.0 sodium succinate; 0.001-10.0 succinic acid; 1.0-10.0 sodium chloride; and up to 1l water for injection. An integrated approach to restoring the synovial balance in a joint cavity and protecting the cartilage is provided, which is achieved through the substitutive effect provided by hyaluronic acid, the activation of the metabolic processes of the cartilage and a strong chondroprotective effect, thereby providing for high clinical effectiveness in the treatment of the musculoskeletal system. The agent is also highly effective in cell renewal, restoring skin suppleness and elasticity, as well as facial tone, colour and texture, and in eliminating signs of aging and fatigue.

Description

technical field [0001] The present invention relates to the chemical and pharmaceutical industries, in particular, to medical products and drugs in the form of intra-articular and intradermal solutions and gels, which can be applied in Orthopedics, Traumatology, Arthrology, Rheumatology (Reumatology) and Vertebrology As an agent to protect cartilage and restore fluid balance in the synovial cavity and in dermatology, medical cosmetic and plastic surgery to delay skin aging. Background technique [0002] A known preparation Ial-System TM 1,8%, produced by Fidia Company (Italy), for the repair and prevention of skin aging. The above preparations contain only one active substance - hyaluronic acid of non-animal origin. IAL-System TM Each package of ® includes a pre-filled single-use syringe containing 1.1ml. of the active solution, which requires no diluent and is ready-to-use. This drug is administered intradermally with a fine needle. This preparation is registered in Uk...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K31/194A61K33/14A61K33/00A61P19/00A61P43/00
CPCA61K31/728A61K31/194A61P17/00A61P19/00A61P19/02A61P43/00
Inventor N·N·徳卡驰N·I·古曼尼科M·V·科兹霍夫
Owner ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ИНСТИТУТ ГИАЛУАЛЬ"
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