Helicobacter pylori antigen HLA restrictive immunodominance epitope peptide and preparation method and application thereof

A Helicobacter pylori and dominant epitope technology, applied in the field of medical biology, can solve the problems of unavoidable epitopes, missed screening, and low accuracy
CN102746381AActive Publication Date: 2012-10-24ARMY MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ARMY MEDICAL UNIV
Publication Date
2012-10-24

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Abstract

The invention relates to Helicobacter pylori antigen HLA restrictive immunodominance epitope peptide as well as a preparation method and application thereof. The dominance epitope peptide has the amino acid sequences shown in SEQ ID NO:63, 74, 95 and 105. The invention also provides a preparation method of the epitope peptide, and further provides application of the epitope peptide to preparation for preventing or treating Helicobacter pylori infection.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and biology, and relates to a Helicobacter pylori antigen HLA-restricted immunodominant epitope peptide and a preparation method and application thereof. Background technique

[0002] In 1982, Australian scholars Warren and Marshall discovered a microaerophilic, Gram-negative, Helicobacter pylori (Helicobacter pylori, Hp) colonized in the human stomach and duodenum. Helicobacter pylori is the main pathogenic bacteria of the upper gastrointestinal tract, and is closely related to the occurrence of diseases such as gastritis, peptic ulcer, gastric mucosa-associated lymphoid tissue lymphoma (MALT) and gastric cancer. Studies in recent years have shown that Helicobacter pylori infection is also associated with extragastric diseases such as ischemic heart disease, atherosclerosis, and iron deficiency anemia. In 1994, the World Health Organization listed it as the first carcinogen in the population. ...

Claims

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