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Procaine penicillin-dihydrostreptomycin sulphate suspension injection and preparation method thereof

A technology of streptomycin sulfate, procaine penicillin, applied in liquid delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problem of weak action of Gram-negative bacteria, achieve complementary efficacy and increase clinical The effect of medication safety factor and treatment cost saving

Inactive Publication Date: 2012-11-28
上海公谊药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the unilateral procaine penicillin has a weak effect on Gram-negative bacteria, and at the same time, it has developed severe drug resistance to Staphylococcus aureus, the main pathogen causing mastitis in livestock

Method used

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  • Procaine penicillin-dihydrostreptomycin sulphate suspension injection and preparation method thereof
  • Procaine penicillin-dihydrostreptomycin sulphate suspension injection and preparation method thereof
  • Procaine penicillin-dihydrostreptomycin sulphate suspension injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] formula:

[0032]

[0033] Preparation:

[0034] Take 50ml of water for injection, dissolve benzyl alcohol, sodium formaldehyde sulfoxylate, polyvinylpyrrolidone and dihydrostreptomycin sulfate in sequence, filter, sterilize at 100°C for 30 minutes, let cool to below 25°C, and put in procaine For penicillin, add water for injection to make up 100ml, stir and disperse to obtain the product.

Embodiment 2

[0036] formula:

[0037]

[0038]

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0041] By penicillin sodium powder for injection, the preparation of dihydrostreptomycin sulfate for injection and embodiment 2, adopt the method specified in Ministry of Agriculture's "Technical Specifications for Veterinary Drug Testing", compare pharmacokinetics, and the test results are as follows:

[0042]

[0043] The test results show that: the pharmacokinetic parameters of the compound preparation of this product are significantly better than those of penicillin and dihydrostreptomycin sulfate single preparations, the blood drug concentration is high, the maintenance time of drug effect is significantly prolonged, and the clinical drug effect is remarkable.

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PUM

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Abstract

The invention discloses a procaine penicillin-dihydrostreptomycin sulphate suspension injection and a preparation method thereof. Injection water is used as a carrier; and every 100 millimeters of injection comprise 15 to 25 grams of procaine penicillin and 20 to 30 grams of dihydrostreptomycin sulphate. The procaine penicillin-dihydrostreptomycin sulphate suspension injection has the beneficial effects that the product is long-acting and is a stable organic alkali doubled salt; the shortcomings that the single penicillin in an animal body is short in effective blood concentration time, and the main pathogenic bacterium, namely staphylococcus aureus, which causes gerget of livestock, resists the conventional single penicillin are overcome; the procaine penicillin-dihydrostreptomycin sulphate suspension injection can kill germs coordinatively; the pesticide effect is complementary; an effect of forcibly killing the germs is achieved; the clinical safety coefficient is increased; the procaine penicillin-dihydrostreptomycin sulphate suspension injection is economic and substantial; the treating effect is obvious; and the treating cost can be effectively saved.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating streptococcus infection in livestock and mixed infection of Gram-positive bacteria and Gram-negative bacteria. Background technique [0002] Antibacterial drugs play a pivotal role in the development of today's intensive animal husbandry, and are a main force in the treatment and prevention of livestock and poultry diseases. However, when various factors lead to poor oral bioavailability of the drug, or when it is not suitable for oral administration, injection administration becomes a necessary administration method, but most antibacterial drugs need to be used multiple times a day in clinical application to meet the treatment requirements , the stress caused to animals is large, and more manpower is needed, which brings a lot of inconvenience to the large-scale breeding industry. Therefore, the market demand for sustained-release preparations of this type of drug is increasing, and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/43A61K31/245A61K9/10A61P31/04
Inventor 廖雪玲顾岳明
Owner 上海公谊药业有限公司
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