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Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

An oxygen and compound technology, applied in the field of providing 4'-arylmethoxyisoindoline compounds, can solve problems such as difficult to treat diseases or conditions

Active Publication Date: 2015-02-25
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Other diseases or conditions associated with or characterized by unwanted angiogenesis are also difficult to treat

Method used

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  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
  • Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Examples

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Embodiment Construction

[0019] In one embodiment, isoindoline compounds, and pharmaceutically acceptable salts, solvates, prodrugs, clathrates, and stereoisomers thereof are provided.

[0020] In another embodiment, there is provided a method of treating, managing or preventing various diseases and conditions comprising administering to a patient in need of such treatment or prevention a therapeutically or prophylactically effective amount of a compound provided herein, or a pharmaceutically effective amount thereof Acceptable salts, solvates, prodrugs, clathrates, or stereoisomers. Examples of diseases and conditions are described herein.

[0021] In other embodiments, a compound provided herein, or a pharmaceutically acceptable salt, solvate, prodrug, clathrate, or stereoisomer thereof, is combined with another drug ("second active drug") or a combination of treatments. Second active drugs include small molecules and macromolecules (eg, proteins and antibodies), examples of which are provided her...

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Abstract

Provided are 4'-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Description

1. Technical field [0001] The present invention provides 4'-arylmethoxyisoindoline compounds. The invention also discloses a pharmaceutical composition comprising the compound and methods for treating, preventing and managing various diseases using the compound and the composition. 2. Background technology [0002] 2.1 Pathology of cancer and other diseases [0003] Cancer is primarily characterized by an increase in the number of abnormal cells from a given normal tissue, the invasion of adjacent tissues by these abnormal cells, or the spread of malignant cells to local lymph nodes and more distant sites by lymphatic or hematologic spread (metastasis). Clinical data and molecular biology studies suggest that cancer is a multistep process that begins with minor precancerous changes and progresses to neoplasia under specific conditions. Neoplastic lesions can develop asexually and have increased capabilities for invasion, growth, metastasis, and heterogeneity, especially u...

Claims

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Application Information

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IPC IPC(8): C07D401/04C07D401/14C07D407/12C07D413/14C07D417/14C07D487/04C07D493/04C07D495/04C07D491/107C07D407/14C07D409/14A61P35/00A61K31/4412
CPCC07D401/14C07D495/04C07D417/14C07D471/04C07D413/14C07D407/14C07D491/107C07D493/04C07D487/04C07D409/14C07D407/12C07D401/04C07D405/14C07D498/08C07D401/12A61P11/00A61P17/00A61P19/02A61P21/00A61P25/00A61P25/04A61P25/20A61P27/02A61P29/00A61P31/00A61P31/18A61P33/00A61P35/00A61P37/02A61P37/04A61P39/02A61P43/00A61P7/00A61P7/06A61P9/00A61P9/10A61P9/14A61P7/04A61K31/4412
Inventor 汉华·曼乔治·W·穆勒亚历山大·卢切尔曼埃哈卜·M·哈利勒罗杰·沈-楚·陈张魏红
Owner CELGENE CORP
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