Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing compound salvia chinensis medicinal granule

A technology of purple ginseng and granules, which is applied in the field of preparation of compound purple ginseng granules, which can solve the problems of many impurities, rough process, and large dosage for patients

Inactive Publication Date: 2012-12-26
NANJING ZHENGLIANG MEDICAL TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of compound Zishen Granules. However, the method of water extraction is rough and backward in process and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take and serious. Affected the clinical application of this product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 250g of Shi Jianchuan, 250g of Salvia miltiorrhiza, 250g of Radix Glycyrrhizae, 150g of Angelica Root, 150g of Cyperus officinalis, 150g of Turmeric, 100g of Safflower, 150g of Turtle A 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30℃, CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain a supercritical extract, which is used for later use. , extraction power 400W, extraction twice, 4 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluent, and recovered ethanol under reduced pressure , concentrated and dried to obtain a microwave extract, which is for later use; mix the above-mentioned supercritical extract and microwave extract, add starch, granulate with 70% ethan...

Embodiment 2

[0026] Take 250g of Shi Jianchuan, 250g of Salvia miltiorrhiza, 250g of Radix Glycyrrhizae, 150g of Angelica Root, 150g of Cyperus officinalis, 150g of Turmeric, 100g of Safflower, 150g of Turtle A 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50℃, CO 2 The flow rate is 3m1 / g crude drug·min, and the extraction time is 180min, to obtain a supercritical extract, which is used for later use. , extraction power 600W, extraction twice, 8 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluent, and recovered ethanol under reduced pressure , concentrated and dried to obtain a microwave extract, which is for later use; mix the above-mentioned supercritical extract and microwave extract, add starch, granulate with 70% etha...

Embodiment 3

[0029] Take 250g of Shi Jianchuan, 250g of Salvia miltiorrhiza, 250g of Radix Glycyrrhizae, 150g of Angelica root, 150g of Cyperus officinalis, 150g of Turmeric, 100g of safflower, 150g of Turtle A 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, and the extraction time is 160min, to obtain a supercritical extract, which is used for later use; take Shijianchuan, Salvia miltiorrhiza, Scutellaria chinensis, and turtle shell, pulverize, add 2L of 70% ethanol, and put it into a microwave extraction device for microwave extraction. , extraction power 500W, extraction twice, 6 minutes each time, combined extracts, concentrated, added to D101 macroporous adsorption resin column, eluted with 50% ethanol, collected 5 times the column volume eluent, and recovered ethanol under reduce...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method for preparing a compound salvia chinensis medicinal granule. The compound salvia chinensis medicinal granule is prepared by performing ultra-critical extraction and microwave extraction on 250g of salvia chinensis, 250g of red-rooted salvia root, 250g of suberect spatholobus stem, 150g of Chinese angelica, 150g of nutgrass galingale rhizome, 150g of turmeric root-tuber, 100g of safflower and 150g of turtle shell serving as bulk pharmaceuticals, so that the tanshinone content is increased greatly.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of compound Zishen granules. Background technique [0002] Compound Zishen Granule is recorded in the Ministry of Health standard WS3-B-0113-89, consisting of 250g of Shijianchuan, 250g of Salvia miltiorrhiza, 250g of Radix Glycyrrhizae, 150g of Angelica sinensis, 150g of Cymbidium vulgaris, 150g of turmeric, 100g of safflower, and 150g of turtle shell. Made of raw materials, it can soothe the liver and regulate qi, activate blood and disperse knots. For hepatosplenomegaly caused by advanced schistosomiasis. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of compound purple ginseng granules, but the method of water extraction is rough, backward, and has many impurities, resulting in excessive patient dosage, inconvenient to take, and serious...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/9066A61K9/16A61P33/12A61P1/16A61P1/00
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH