Compound nano-silver emulsifiable paste and preparation method thereof

A nano-silver and cream technology, applied in the field of medicine, can restore the health of the wounded, promote wound healing, and reduce combat attrition.

Inactive Publication Date: 2014-07-02
中国人民解放军济南军区第四0一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the problems referred to above, the present invention provides a kind of compound nano-silver emulsifiable paste, and this emulsifiable paste is the O / W type emulsifiable paste or the W / O emulsifiable paste that is made through certain preparation process with nano-silver and zinc oxide as main ingredients, Nano-silver has strong antibacterial effect, wide antibacterial spectrum, and bacteria are not easy to develop resistance to it. Zinc oxide has the effect of astringent and promoting wound healing. The cream made by combining the two drugs has both anti-infection effect and promoting wound healing The cream combines the therapeutic advantages of MEBO and silver sulfadiazine cream and avoids the deficiency and adverse reactions of its treatment

Method used

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  • Compound nano-silver emulsifiable paste and preparation method thereof
  • Compound nano-silver emulsifiable paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Components and content of compound nano silver cream: 59.1g stearic acid, 59.1g stearyl alcohol, 118.2g liquid paraffin, 0.5g ethylparaben, 4.6g triethanolamine, 10.1g laurocaprolactone, 2,6 - 0.5g of di-tert-butyl-p-cresol, 0.5g of disodium edetate, 228g of glycerin, 232.6mL of nano-silver solution, 40g of zinc oxide, and add water to 1000g.

[0040] Preparation:

[0041] (1) Preparation of water phase: Add zinc oxide, glycerin, disodium edetate and ethylparaben to an appropriate amount of nano-silver solution, heat to 80°C, stir well, and set aside.

[0042] (2) Oil phase preparation: Mix stearic acid, stearyl alcohol, 2,6-di-tert-butyl-p-cresol, laurocaprazine and liquid paraffin, heat to 75°C, and stir well.

[0043] (3) Immediately add the water phase to the oil phase, then add triethanolamine, stop heating, and immediately stir rapidly, when the temperature drops to 50°C, continue stirring until it coagulates, and the compound nano silver cream is obtained.

Embodiment 2

[0045] The composition and content of the compound nano silver cream: stearic acid 59.1g, stearyl alcohol 59.1g, liquid paraffin 118.2g, triethanolamine 4.6g, glycerin 228g, nano silver liquid 200mL, zinc oxide 50g, add water to 1000g.

[0046] Preparation:

[0047] (1) Preparation of water phase: Mix glycerin and nano-silver solution, heat to 80°C, stir well, and set aside.

[0048] (2) Preparation of oil phase: Mix stearic acid, stearyl alcohol and liquid paraffin, heat to 75°C, stir well, and set aside.

[0049] (3) Immediately add the water phase to the oil phase, then add triethanolamine, stir until the emulsification is complete, add zinc oxide fine powder in stages, stir evenly, let cool to room temperature, and obtain the compound nano silver cream.

Embodiment 3

[0051] Components and content of compound nano silver cream: 59.1g stearic acid, 59.1g stearyl alcohol, 118.2g liquid paraffin, 4.6g triethanolamine, 10.1g laurocaprazine, 2,6-di-tert-butyl p-methyl 0.5g of phenol, 0.5g of disodium edetate, 228g of glycerin, 300mL of nano-silver solution, 45g of zinc oxide, and add water to 1000g.

[0052] Preparation:

[0053] (1) Preparation of water phase: Mix glycerin, disodium ethylenediaminetetraacetic acid, and nano-silver solution, heat to 80°C, stir well, and set aside.

[0054] (2) Oil phase preparation: Mix stearic acid, stearyl alcohol, 2,6-di-tert-butyl-p-cresol, laurocaprazine and liquid paraffin, heat to 75°C, stir well, and set aside.

[0055] (3) Then slowly add the water phase to the oil phase, stir as you add, then add triethanolamine until the emulsification is complete, add zinc oxide fine powder in stages, stir evenly, and cool to room temperature to obtain the compound nano silver cream .

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Abstract

The invention discloses compound nano-silver emulsifiable paste and a preparation method thereof. The compound nano-silver emulsifiable paste is O / W or W / O type emulsifiable paste prepared from nano-silver and zinc oxide as main drugs by certain processes. Nano-silver has strong antibacterial effects and a wide antimicrobial spectrum and causes drug resistance of bacteria difficultly. Zinc oxide has convergence and wound heal promotion effects. The compound nano-silver emulsifiable paste prepared from nano-silver and zinc oxide has anti-infection and wound heal promotion effects. The compound nano-silver emulsifiable paste has treatment advantages of moisture exposed burn ointment and sulfadiazine silver cream and avoids treatment defects and adverse reactions of moisture exposed burn ointment and sulfadiazine silver cream. The compound nano-silver emulsifiable paste can be used for anti-infection treatment on burns and scalds, infected wounds caused by physical mechanical damages, and chronic surface ulcers, and promotion of wound heal. The compound nano-silver emulsifiable paste can also be used for treatment on skin diseases such as sores, carbuncles, furuncles, erysipelas and tinea caused by bacteria, fungi and viruses.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound nano-silver cream and a preparation method thereof. Background technique [0002] Burns and scalds are relatively common clinically, especially in wartime. For burn patients, external medicine plays an important role in preventing wound infection, wound bacteria invading deep layers and promoting wound healing. At present, external medicines for treating burns and scalds include traditional Chinese medicine represented by moist burn ointment and western medicine represented by silver sulfadiazine cream. The former can provide a moist environment conducive to wound regeneration, but its antibacterial effect is poor; The latter has a good anti-infection effect due to the dual antibacterial effects of silver and sulfadiazine, but the existence of the sulfonamide group makes the drug have local adverse reactions of sulfadiazine, and after percutaneous absorption, it has systemic ad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/38A61K9/107A61K9/06A61P17/02A61P31/04A61K33/30
Inventor 马守栋李明春曹恩惠刘帮国赵丽艳叶勇
Owner 中国人民解放军济南军区第四0一医院
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