Grain size controllable monodisperse polyvinyl alcohol gel microsphere, preparation method thereof and applied device

A polyvinyl alcohol gel microsphere and polyvinyl alcohol gel technology, which is applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problem of difficulty, wide particle size distribution of microspheres, and difficulty in obtaining monodisperse microspheres of uniform size. and other problems, to achieve the effect of short time-consuming, widened application and low cost

Inactive Publication Date: 2013-01-30
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When this emulsion polymerization method prepares microspheres of tens to hundreds of microns, it is difficult to control the formation of droplets with uniform particle size,

Method used

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  • Grain size controllable monodisperse polyvinyl alcohol gel microsphere, preparation method thereof and applied device
  • Grain size controllable monodisperse polyvinyl alcohol gel microsphere, preparation method thereof and applied device
  • Grain size controllable monodisperse polyvinyl alcohol gel microsphere, preparation method thereof and applied device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Add 0.5g of borax to the mixture of 10mL of isoamyl alcohol and 5mL of triethanolamine, magnetically stir and slowly heat to 60°C to dissolve it, and prepare a coagulation bath solution.

[0040] Add 1.0g of polyvinyl alcohol into a beaker containing 12.5mL of deionized water, stir magnetically and slowly heat to 90°C to dissolve it to obtain a dispersed phase solution; mix 30mL of silicone oil and 20mL of isooctyl alcohol evenly to obtain a continuous phase solution.

[0041] Put the above-mentioned dispersed phase solution and continuous phase solution into 1mL and 50mL syringes respectively, place them on two propulsion pumps, connect the microfluidic controller, and set the flow rate of the dispersed phase to 26mm min -1 , the viscosity is 160mPa·s, the continuous phase flow rate is 200mm·min -1 , viscosity 540mPa s, capillary size: outer diameter / inner diameter 165 / 98μm, turn on the microfluidic control device, and prepare monodisperse polyvinyl alcohol solution d...

Embodiment 2

[0043] Add 0.5g of borax to the mixture of 10mL of isoamyl alcohol and 5mL of triethanolamine, magnetically stir and slowly heat to 60°C to dissolve it, and prepare a coagulation bath solution.

[0044] Add 1.0g of polyvinyl alcohol into a beaker containing 12.5mL of deionized water, stir magnetically and slowly heat to 90°C to dissolve it to obtain a dispersed phase solution; mix 30mL of silicone oil and 20mL of isooctyl alcohol evenly to obtain a continuous phase solution.

[0045] Put the above-mentioned dispersed phase solution and continuous phase solution into 1mL and 50mL syringes respectively, place them on two propulsion pumps, connect the microchannel reactor, and set the flow rate of the dispersed phase to 72mm min -1 , the viscosity is 160mPa·s, and the flow rate of the continuous phase is 127mm·min -1 , viscosity 540mPa s, capillary size: outer diameter / inner diameter 245 / 98μm, turn on the microfluidic control device, prepare monodisperse polyvinyl alcohol soluti...

Embodiment 3

[0047] Add 0.5g of borax to the mixture of 10mL of isoamyl alcohol and 5mL of triethanolamine, magnetically stir and slowly heat to 60°C to dissolve it, and prepare a coagulation bath solution.

[0048] Add 1.0g of polyvinyl alcohol into a beaker containing 12.5mL of deionized water, stir magnetically and slowly heat to 90°C to dissolve it to obtain a dispersed phase solution; mix 30mL of silicone oil and 20mL of isooctyl alcohol evenly to obtain a continuous phase solution.

[0049] Put the above-mentioned dispersed phase solution and continuous phase solution into 1mL and 50mL syringes respectively, place them on two propulsion pumps, connect the microchannel reactor, and set the flow rate of the dispersed phase to 264mm min -1 , the viscosity is 160mPa·s, and the flow rate of the continuous phase is 46mm·min -1 , viscosity 540mPa s, capillary size: outer diameter / inner diameter 360 / 225μm, turn on the microfluidic control device, prepare monodisperse polyvinyl alcohol solut...

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Abstract

The invention relates to a preparation method for a grain size controllable monodisperse polyvinyl alcohol gel microsphere. The preparation method comprises the following steps: preparing a disperse phase solution and a continuous phase solution; controlling the flowing speed, flow and viscosity of the disperse phase and the continuous phase; obtaining polyvinyl alcohol solution drops in different grain sizes and in uniform diameter size after converging the disperse phase with the continuous phase; and solidifying the drops, thereby obtaining the grain size controllable monodisperse polyvinyl alcohol gel microspheres. The invention also relates to a preparation device for the grain size controllable monodisperse polyvinyl alcohol gel microsphere and the prepared monodisperse polyvinyl alcohol gel microsphere. The microsphere prepared according to the invention has a better surface morphology and a grain size range of 50-600 microns. The preparation device is convenient to assemble and disassemble; the size controllable preparation for a monodisperse polyacrylamide microsphere is realized by changing the size of a capillary tube or controlling the flowing speed or viscosity of the disperse phase and the continuous phase; and the grain size distribution coefficient CV is less than 5%.

Description

technical field [0001] The invention relates to the field of preparation of monodisperse microspheres, in particular to a monodisperse polyvinyl alcohol gel microsphere with controllable particle size, a preparation method and a device thereof. Background technique [0002] Polyvinyl alcohol (PVA) gel microspheres have the characteristics of non-toxicity and good biocompatibility, and are widely used in aspects such as controlling drug release rate, prolonging action time, and targeting specific tissues and organs. Zhao Daqing and others used emulsion polymerization technology to obtain PVA gel microspheres with aldehyde or borax as a crosslinking agent, but this technology can only use low-concentration PVA solutions, resulting in insufficient mechanical properties of PVA gel microspheres. Gao Suzhao et al. used high-voltage electrostatic technology to obtain PVA gel microspheres for the preparation of porous three-dimensional cell scaffolds. The PVA microspheres obtained b...

Claims

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Application Information

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IPC IPC(8): B01J13/14
Inventor 常振旗韦正友
Owner UNIV OF SCI & TECH OF CHINA
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