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Miniaturized magnetic fluxgate biosensor for serum tumor marker detection

A fluxgate sensor and tumor marker technology, applied in the field of biosensors, can solve the problems of no miniaturized fluxgate sensor, low sensitivity of a single index, lack of flexibility, etc., to achieve real-time analysis, no special environment and storage requirements, the effect of high detection sensitivity

Active Publication Date: 2013-02-20
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the shortcomings of these methods are the lack of flexibility, low sensitivity and poor specificity of single indicators.
Through literature and patent searches, no relevant research results were found on the use of miniaturized fluxgate sensors for the detection of serum tumor markers

Method used

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  • Miniaturized magnetic fluxgate biosensor for serum tumor marker detection
  • Miniaturized magnetic fluxgate biosensor for serum tumor marker detection
  • Miniaturized magnetic fluxgate biosensor for serum tumor marker detection

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Embodiment Construction

[0032] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0033] This embodiment provides a miniaturized fluxgate biosensor for detecting serum tumor markers. The biosensor includes a miniaturized fluxgate sensor, a biochip, a solenoid coil for applying an axial magnetic field, and a signal acquisition system connected with the miniaturized fluxgate sensor.

[0034] The miniaturized fluxgate sensor is located on a glass substrate, which can be realized by using existing technologies, such as the sensor recorded in the Chinese patent application number 20...

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Abstract

The present invention provides a miniaturized magnetic fluxgate biosensor for serum tumor marker detection. The biosensor comprises a miniaturized magnetic fluxgate sensor positioned on a glass substrate, a biochip and a signal acquisition system, wherein the biochip comprises a Au film on the glass substrate, a bio-sensitive film and a magnetic tag, the Au film is a sputtered Cr / Au film, the bio-sensitive film is a self-assembled film having a nano-scale thickness, and can be linked with various monoclonal antibodies, and the magnetic tag comprises streptavidin-modified magnetic nanoparticles or magnetic beads formed by magnetic nanoparticles, and can be combined with biotin modified monoclonal antibodies or polyclonal antibodies. According to the biosensor, the detection principle adopts a double antibody sandwich method, and the detection sensitivity is that serum tumor marker antigen having a concentration up to 1 ng / ml can be detected.

Description

technical field [0001] The invention relates to a biosensor, in particular to a miniaturized fluxgate biosensor for detecting serum tumor markers, belonging to the technical fields of medical detection methods and magnetic sensing. Background technique [0002] Malignant tumors are one of the major diseases that threaten human health and life today, and the incidence rate is increasing year by year. At present, the main clinical tumor detection methods include: [0003] [1] Laboratory examination: mainly includes routine examination of blood, urine, and stool, biochemical and immune examination, pathological examination, etc. [0004] [2] Radiological examination: mainly including X-ray fluoroscopy, X-ray film, X-ray contrast examination, CT scan, nuclear magnetic resonance imaging, etc. [0005] [3] Radionuclide inspection: that is, isotope inspection, including functional measurement inspection, scanning and gamma irradiation inspection, radioimmunoassay, etc. [0006] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
Inventor 周勇雷冲雷剑
Owner SHANGHAI JIAO TONG UNIV
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