Aspirin eugenol ester-paracetamol compound sustained-release tablet

A technology of acetaminophen and compound sustained-release tablets, which is applied in the field of medicine, can solve problems such as difficulties, and achieve long-lasting effects, high drug safety, and long-lasting effects

Inactive Publication Date: 2013-02-27
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] After conventional preparations are taken, the drug concentration rises rapidly to the maximum value, and then decreases rapidly due to metabolism, excretion and degradation. It is difficult to control the drug concentration between the minimum effective concentration and the maximum safe concentration

Method used

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  • Aspirin eugenol ester-paracetamol compound sustained-release tablet

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Prescription: aspirin eugenol ester 340g, acetaminophen 250g, vitamin C 80g, hydroxypropyl cellulose 50g, low-substituted hydroxypropyl cellulose 180g, sodium alginate 100g, talcum powder 10g, 5% povidone ethanol solution Appropriate amount, a total of 1000 tablets; pass each component in the prescription through a 100-mesh sieve, and set aside; mix the porogen and diluent evenly with the slow-release material in an equal increment method, and then mix with aspirin eugenol ester 1. Mix paracetamol and vitamin C evenly; prepare soft material with binder, pass through 20 mesh sieve to make wet granules, blow dry at 60°C, granulate with 18 mesh sieve, add lubricant, mix evenly, and press into tablets.

Embodiment 2

[0028] Prescription: aspirin eugenol ester 320g, acetaminophen 200g, vitamin C 100g, hydroxypropyl cellulose 100g, low-substituted hydroxypropyl cellulose 110g, sodium alginate 140g, talcum powder 10g, 5% povidone ethanol solution Appropriate amount, a total of 1000 tablets; pass each component in the prescription through a 100-mesh sieve, and set aside; mix the porogen and diluent evenly with the slow-release material in an equal increment method, and then mix with aspirin eugenol ester 1. Mix paracetamol and vitamin C evenly; prepare soft material with binder, pass through 20 mesh sieve to make wet granules, blow dry at 60°C, granulate with 18 mesh sieve, add lubricant, mix evenly, and press into tablets.

Embodiment 3

[0030] Prescription: aspirin eugenol ester 400g, acetaminophen 320g, vitamin C 60g, hydroxypropyl cellulose 360g, low-substituted hydroxypropyl cellulose 300g, sodium alginate 40g, talcum powder 10g, 5% povidone ethanol solution Appropriate amount, a total of 1000 tablets; pass each component in the prescription through a 100-mesh sieve, and set aside; mix the porogen and diluent evenly with the slow-release material in an equal increment method, and then mix with aspirin eugenol ester 1. Mix paracetamol and vitamin C evenly; prepare soft material with binder, pass through 20 mesh sieve to make wet granules, blow dry at 60°C, granulate with 18 mesh sieve, add lubricant, mix evenly, and press into tablets.

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PUM

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Abstract

The invention relates to an aspirin eugenol ester-paracetamol compound sustained-release tablet. The aspirin eugenol ester-paracetamol compound sustained-release tablet is prepared from aspirin eugenol ester, paracetamol and vitamin C. The aspirin eugenol ester-paracetamol compound sustained-release tablet has effects of effectively relieving fever, headache and upper airway symptoms caused by common cold and influenza and various symptoms caused by the hay fever, is suitable for treating cold-related symptoms, and contains active components which are released slowly.

Description

[0001] technical field [0002] The invention discloses an aspirin eugenol ester acetaminophen sustained-release tablet, and also provides a preparation method thereof, belonging to the technical field of medicine. technical background [0003] Aspirin eugenol ester (AEE) is a combination of eugenol, a volatile oil component extracted from the traditional Chinese medicine clove, which has antibacterial, antipyretic, and antioxidant effects, and anti-inflammatory, analgesic, Antipyretic, anticancer and other classic western medicine aspirin synthesizes a new type of anti-infective drug through esterification reaction. This drug solves the shortcomings and side effects of the two drugs used alone. At the same time, it can also relieve various secondary symptoms such as fever, pain, and inflammation caused by germs, achieve the effect of treating both symptoms and root causes, and reduce drug costs while curing diseases faster and better. [0004] Acetaminophen is an analgesic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K9/22A61P29/00A61P31/04A61K31/167A61K31/375
Inventor 滕利荣田野孟庆繁王贞佐逯家辉程瑛琨刘艳孟令军
Owner JILIN UNIV
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