Gel for lysozyme eye and preparation method thereof

A technology of ophthalmic gel and lysozyme, which is applied in the biological field to achieve good affinity, no toxic side effects, and improve bioavailability

Inactive Publication Date: 2013-03-13
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Water-soluble polymers are selected

Method used

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  • Gel for lysozyme eye and preparation method thereof
  • Gel for lysozyme eye and preparation method thereof
  • Gel for lysozyme eye and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] prescription:

[0032] Lysozyme 0.5g

[0033] Hypromellose 4.0g

[0034] Boric acid 0.8g

[0035] Chlorobutanol 0.125g

[0036] Benzalkonium Chloride 0.01g

[0037] Glycerin 1.35g

[0038] Appropriate amount of water for injection

[0039]

[0040] Preparation: 100ml (adjust the pH value to 5.0~6.5 with sodium hydroxide solution)

[0041] Process:

[0042] 1) Heating water for injection to prepare a hypromellose solution for subsequent use.

[0043] 2) Add the prescribed amount of chlorobutanol and stir to dissolve; cool down and add the prescribed amount of boric acid and stir to dissolve; add the prescribed amount of glycerin, stir, then cool down, add the prescribed amount of lysozyme and stir to dissolve; finally add the prescribed amount Stir the benzalkonium chloride to dissolve, adjust the pH value with sodium hydroxide solution, add water for injection to a sufficient amount, and continue to stir to make it uniform.

[0044] 3) Mix the solutions in 1...

Embodiment 2

[0046] prescription:

[0047] Lysozyme 1g

[0048] povidone 10g

[0049] Boric acid 0.8

[0050] Chlorobutanol 0.125g

[0051] Benzalkonium Chloride 0.01g

[0052] Glycerin 1.35g

[0053] Appropriate amount of water for injection

[0054]

[0055] Preparation: 100ml (adjust the pH value to 5.0~6.5 with sodium hydroxide solution)

[0056] Process:

[0057] 1) Heating water for injection to prepare povidone solution and set aside.

[0058] 2) Add the prescribed amount of chlorobutanol and stir to dissolve; cool down and add the prescribed amount of boric acid and stir to dissolve; add the prescribed amount of glycerin, stir, then cool down, add the prescribed amount of lysozyme and stir to dissolve; finally add the prescribed amount Stir the benzalkonium chloride to dissolve, adjust the pH value with sodium hydroxide solution, add water for injection to a sufficient amount, and continue to stir to make it uniform.

[0059] 3) Mix the solutions in...

Embodiment 3

[0061] prescription:

[0062] Lysozyme 5g

[0063] Methylcellulose 20g

[0064] Boric acid 0.8g

[0065] Chlorobutanol 0.125g

[0066] Benzalkonium Chloride 0.01g

[0067] Glycerin 1.35g

[0068] Appropriate amount of water for injection

[0069]

[0070] Preparation: 100ml (adjust the pH value to 5.0~6.5 with sodium hydroxide solution)

[0071] Process:

[0072] 1) Heat water for injection to prepare methylcellulose solution and set aside.

[0073] 2) Add the prescribed amount of chlorobutanol and stir to dissolve; cool down and add the prescribed amount of boric acid and stir to dissolve; add the prescribed amount of glycerin, stir, then cool down, add the prescribed amount of lysozyme and stir to dissolve; finally add the prescribed amount Stir the benzalkonium chloride to dissolve, adjust the pH value with sodium hydroxide solution, add water for injection to a sufficient amount, and continue to stir to make it uniform.

[0074] 3) Mix the solutions in 1) and 2...

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PUM

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Abstract

The invention relates to a gel for lysozyme eye and a preparation method thereof. The gel for the lysozyme eye is applicable of treating various normal eye infection diseases, such as a pinkeye, an ophthalmia, a ceratitis, a keratohelcosis, a conjunctivitis and the like, which is caused by bacteria, Chlamydia, virus and drug-resistance bacteria. The gel for the lysozyme eye disclosed by the invention uses a solution containing 0.1-10.0% of lysozyme, 0.01-20% of water soluble macromolecule matrix, 0.1-10% of a pH modifier, 0.01-10% of a bacteriostat and 0.1-10% of a viscosity modifier and takes a solution with a pH value of 5.0-6.5 as a buffer solution. With the adoption of the receipt of the gel for the lysozyme eye provided by the invention, the time that drug lysozyme remains on an eye can be prolonged, and the bacteriostat efficiency of the lysozyme on the eye can be improved.

Description

technical field [0001] The invention relates to the field of biotechnology, and relates to a lysozyme ophthalmic gel and a preparation method thereof. The gel treats various pink eye diseases, keratitis, corneal ulcers, Common eye infections such as conjunctivitis. Background technique [0002] Common clinical infectious eye diseases, such as conjunctivitis and keratitis, are mostly bacterial infections. At present, antibiotic eye drops are the most commonly used for the treatment of bacterial eye diseases, but drug resistance is prone to develop. With the extensive use of antibiotics, drug-resistant strains are also increasing. And antibiotic eye drops should not be used for a long time because of their side effects. Therefore, the development of new ophthalmic preparations for the treatment of bacterial eye diseases has become a research hotspot. [0003] Lysozyme is a non-specific immune factor that exists in the normal body fluids and tissues of the human body. It has...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K38/47A61K47/38A61P31/04A61P31/12A61P27/02
Inventor 王思玲姜同英王笑笑
Owner SHENYANG PHARMA UNIVERSITY
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