Method for decoloring cephalosporin

A cephalosporin and anion technology, which is applied in the field of cephalosporin preparation, can solve the problems of high price, heavy pollution, high environmental protection pressure of acetic acid waste liquid, etc., and achieves the advantages of saving raw material cost, prolonging economic benefit and saving environmental protection treatment cost. Effect

Active Publication Date: 2015-01-28
GUANGZHOU LIXIN PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cephalosporins have weak antibacterial activity and basically have no clinical value. However, using cephalosporins as starting materials, the mother nuclei of two major β-lactam antibiotics, 7-ACA and 7-ADCA, can be obtained, and then chemically modified to produce several Ten kinds of cephalosporin drugs commonly used in clinical practice, and cephalosporin drugs are currently the most widely used class of antibiotics in China. It can be seen that the production of cephalosporins has important strategic value
[0003] The preparation of 7-ACA and 7-ADCA nuclei used to use chemical cracking method, which has high toxicity, heavy pollution and great pressure on environmental protection
First of all, the price of acetic acid, the raw material used for resin transformation, is relatively high; secondly, the acetic acid waste liquid produced in the production process is under great pressure on environmental protection

Method used

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  • Method for decoloring cephalosporin
  • Method for decoloring cephalosporin
  • Method for decoloring cephalosporin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for decolorizing cephalosporins, comprising the following steps:

[0033] 1) Resin transformation

[0034] Take 100mL of Amberlite FPA53 (polyacrylic acid skeleton, the functional group is tertiary amine, and the factory ion form is free hydroxyl) for column packing, and convert them into bicarbonate form and acetic acid form respectively.

[0035] Specifically, taking the bicarbonate type as an example, first pass 400mL of 1.0mol / L sodium bicarbonate solution from the lower end of the Amberlite FPA53 chromatographic column at a flow rate of 4BV / h; then pass 500mL of deionized water from the upper end of the chromatographic column Washing, flow rate 5BV / h, obtain bicarbonate type resin after washing is completed.

[0036] The transformation method of the acetic acid type is basically the same as the above-mentioned steps, only need to change the above-mentioned 1.0mol / L sodium bicarbonate solution into a 1.0mol / L acetic acid solution.

[0037] 2) Decolorizati...

Embodiment 2

[0046] Acetic acid resin was still used as a control.

[0047] 1) Resin transformation

[0048] Each 100mL Amberlite IRA67 was packed into a column, and converted into bicarbonate form and acetic acid form respectively.

[0049] Specifically, taking the bicarbonate type as an example, first pass 250mL of 1.5mol / L ammonium bicarbonate solution from the lower end of the Amberlite IRA67 chromatography column at a flow rate of 2.5BV / h; then pass 600mL of deionized Wash with water at a flow rate of 6BV / h. After the washing is completed, bicarbonate-type resin is obtained.

[0050] The conversion method of the acetic acid type is basically the same as that of the bicarbonate type, and only needs to change the above-mentioned 1.5mol / L ammonium bicarbonate solution into a 1.5mol / L acetic acid solution.

[0051] 2) Decolorization of feed liquid

[0052] The macroporous adsorption resin desorption solution with a light transmittance of 67.4% (light transmittance detection is the same a...

Embodiment 3

[0061] 1) Decolorization of feed liquid

[0062] The macroporous adsorption resin desorption liquid 5000mL of light transmittance 64.3% flows through the resin column decolorization of the Amberlite FPA53 bicarbonate type after the regeneration of embodiment 1, transformation after the flow velocity of 15BV / h, collects the decolorization of cephalosporin at column outlet liquid.

[0063] 2) Regeneration and transformation of resin

[0064] During regeneration, first pass 500mL of 0.5mol / L NaOH solution into the failed resin column layer at a flow rate of 2BV / h, and then wash with deionized water until the pH of the effluent is about 9.5. During transformation, 500mL of 1.0mol / L potassium bicarbonate solution was used to flow through the resin bed at a flow rate of 3BV / h, and finally washed with 1000mL deionized water at a flow rate of 10BV / h.

[0065] At this point, the resin has completed regeneration and transformation, and can be directly used for the next batch of decolo...

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Abstract

The invention discloses a method for decoloring cephalosporin, comprising the following steps: firstly, introducing a bicarbonate solution to an alkalescent acrylic series anion exchange resin column; then washing by using water; transforming the resin type into a potassium bicarbonate type; then enabling macroporous resin stripping liquid of the cephalosporin to constantly flow through the potassium bicarbonate type anion exchange resin column; and collecting a decoloring solution of the cephalosporin at the outlet of the column. As the anion exchange resin for decoloring the macroporous resin stripping liquid of the cephalosporin is improved from an acetic acid type into the potassium bicarbonate type, the decoloring effect is guaranteed, the pressure of acetate ions on the environment and the influence of the acetate ions on enzymatic cracking are avoided, and obvious economic benefits can be obtained.

Description

technical field [0001] The invention belongs to the technical field of preparation of cephalosporins, and relates to a decolorization method of cephalosporins. Background technique [0002] Cephalosporins have weak antibacterial activity and basically have no clinical value. However, using cephalosporins as starting materials, the mother nuclei of two major β-lactam antibiotics, 7-ACA and 7-ADCA, can be obtained, and then chemically modified to produce several Ten kinds of cephalosporin drugs commonly used in clinical practice, and cephalosporin drugs are currently the most widely used class of antibiotics in China. It can be seen that the production of cephalosporins has important strategic value. [0003] The preparation of 7-ACA and 7-ADCA nuclei used to use chemical cracking method, which has high toxicity, heavy pollution and great pressure on environmental protection. In order to meet the increasingly stringent environmental protection requirements, the mainstream pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/12
Inventor 陈斌李蓉贾佳马晓迅陈国亮
Owner GUANGZHOU LIXIN PHARM CO LTD
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