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Method and apparatus for motion correction and image enhancement for optical coherence tomography

A scanning method and imaging technology, applied in image enhancement, image analysis, image data processing and other directions, which can solve problems such as errors and image distortion

Inactive Publication Date: 2013-04-03
MASSACHUSETTS INST OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The relative movement of objects and data acquisition equipment can cause distortion and errors in the obtained images

Method used

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  • Method and apparatus for motion correction and image enhancement for optical coherence tomography
  • Method and apparatus for motion correction and image enhancement for optical coherence tomography
  • Method and apparatus for motion correction and image enhancement for optical coherence tomography

Examples

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Embodiment 1

[0313] attached Figure 16 A to attached Figure 16 C shows the acquisition, registration and merging of two complementary OCT volumes of the optic nerve front end on the human retina. attached Figure 16 Both A and 16B show interpretations of 3D OCT images of the same volume acquired using two mutually perpendicular scan directions. Figure 16C shows the result of merging two images using an exemplary embodiment of the method described in this invention.

[0314] A prototype spectral / Fourier domain OCT system with an axial scan speed of 101 kHz was used to acquire a volume over 6x6 mm scanned with 400x400 pixels in the transverse direction. Each volume is obtained in about 2 seconds. The first volume dataset was obtained by raster scanning with a fast scan in the x-direction, denoted XFast. The data set of the second volume was obtained by raster scanning with a fast scan in the y direction, which is denoted YFast. Both the first and second volume data sets were acquired...

Embodiment 2

[0331] This embodiment is applicable to the case of motion correction and merging of pairs of three-dimensional data sets obtained by vertical raster scanning. An exemplary method for motion correction will be described in detail mathematically, including the establishment of the objective function, the calculation of the transformation and the merging of the motion-corrected 3D-OCT datasets. Also shown are various embodiments using graphics card adjustments, multiple resolution methods, preprocessing and acceleration.

[0332] 1.1 Basic operation

[0333] A depth scan of OCT in the time domain is done by moving mirrors that reflect a reference beam. Different positions on how far the mirror of the reference arm is from the depth profile of the tissue can be reconstructed using the detector. Therefore, OCT in the time domain involves scanning the mirror surface of the reference arm over a certain range, thereby forming a depth or axial scan. In Fourier or OCT in the frequen...

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Abstract

Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The three dimensional transforms are computed based on an objective function that accounts for similarity between the transformed three-dimensional data sets and the estimated motion of the object relative to an imaging instrument. Methods and systems described herein advantageously eliminate the need for postulated assumptions and reliance on landmarks and are capable of filling data gaps, thereby producing high quality, undistorted images of objects subject to movement during imaging. Multiple motion-corrected data sets can be merged or combined to produce a data set with improved image quality.

Description

[0001] government support [0002] All or part of this invention is supported by NIH, the approval documents are R01-EY011289-24 and R01-CA075289-13, and signed contracts FA9550-07-1-0101 and FA9550-07-1-0014 with the scientific research department of the Air Force . Accordingly, the Government has certain rights in this invention. [0003] related application [0004] This application hereby claims the benefit of US Provisional Application No. 61 / 329,347, filed April 29, 2010. The entire teaching of said application is incorporated herein by reference. Background technique [0005] Optical coherence tomography (OCT) acquires cross-sectional images and Stereo dataset. Relative movement of objects and data acquisition equipment can cause distortion and errors in the images obtained. Contents of the invention [0006] An exemplary embodiment of the invention is a method of processing a data set. The method includes calculating one or more three-dimensional transformatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B3/12G06T7/00
CPCA61B3/102G06T2207/30041G06T7/0024G06T2207/10101G06T7/30G06T7/248A61B3/0025G06T11/006
Inventor M·F·G·克劳斯B·M·波特赛德J·G·富基蒙托M·A·梅耶R·博克J·霍纳格
Owner MASSACHUSETTS INST OF TECH
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