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Remote ischemic conditioning for treatment and prevention of restenosis

A kind of restenosis, remote technology, used in physical therapy, tourniquets, blood diseases, etc., can solve problems such as worthless cost and complicated stents

Inactive Publication Date: 2013-04-10
HOSPITAL FOR SICK CHILDREN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these stents are also complicated by restenosis and have their own disadvantages that are not worth the cost

Method used

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  • Remote ischemic conditioning for treatment and prevention of restenosis
  • Remote ischemic conditioning for treatment and prevention of restenosis
  • Remote ischemic conditioning for treatment and prevention of restenosis

Examples

Experimental program
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Embodiment Construction

[0127] method

[0128] Twelve New Zealand White Rabbits (average body weight 3.4 kg) underwent general anesthesia with intramuscular pentobarbital followed by nitrous oxide. After endotracheal intubation, mechanically controlled ventilation to maintain a PaCO of 32-35 mmHg 2 (by intermittent blood gas analysis). After completion of the instrumentation, the animals were stabilized for 5 minutes and then a sham or true ischemic preconditioning stimulus was performed. The ischemic preconditioning stimulus consisted of 4 cycles of 5 minutes of left hindlimb ischemia followed by 5 minutes of reperfusion. Tourniquet effectiveness was checked with pulse oximetry of the ipsilateral foot and visual inspection for pallor during ischemia and redness during reperfusion. Animals in the sham group were treated similarly, with a similar duration of anesthesia, during which sham tightening of the tourniquet placed around the hindlimb was performed, but no occlusion of blood flow or recove...

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PUM

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Abstract

The invention provides methods for reducing the incidence and / or severity of restenosis through the use of remote ischemic conditioning.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application Serial No. 61 / 300,316, entitled "Treatment and Prevention of Restenosis," filed February 1, 2010, which is incorporated herein by reference in its entirety. Background of the invention [0003] Restenosis or renarrowing of vessels or other narrowed biological structures is a common complication following dilation or stenting. It can occur anywhere from about 10%-50% of patients. Certain drug-eluting stents have been reported to be associated with lower rates of restenosis. However, these stents are also complicated by restenosis and have their own disadvantages that are not worth the cost. Patients who develop restenosis typically must undergo a repeated procedure in order to re-dilate or bypass the stenosis. Summary of the invention [0004] The present invention generally relates to the use of remote ischemic conditioning (RIC) to reduce the incidence and severity of re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61H23/04
CPCA61B17/1355A61B2017/00557A61H23/04A61H2201/165A61H2205/067A61P7/02A61P9/10
Inventor 安德鲁·雷丁顿克里斯托弗·卡尔达罗内
Owner HOSPITAL FOR SICK CHILDREN
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