Photo-response micro-fluid self-driven micro-fluidic chip and preparation method thereof

A microfluidic chip and microfluidic technology, applied in the direction of chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve problems such as no substantive breakthroughs, achieve good application prospects, simple operation, cost reduction effect

Inactive Publication Date: 2013-04-17
SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, conventional technologies are difficult to intelligently drive microfluids in microchannels. Therefore, by using light to control changes in surface wettability to drive microfluidics in microfluidic chips,

Method used

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  • Photo-response micro-fluid self-driven micro-fluidic chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The microstructure and microchannel pattern of the two-layer chip of the microfluidic chip with controllable microfluidic flow are designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer polymethyl methacrylate (PMMA) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to make a smart microvalve based on a microfluidic chip. The sample solution is added to the injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump. In the microvalve area of ​​the microchann...

Embodiment 2

[0024] The microstructure and microchannel graphics of the two-layer chip of the centrifugal microfluidic chip were designed and drawn by computer-aided design software. The microstructure and microchannel of the two-layer disc-shaped polycarbonate (PC) chip were processed and prepared by the numerical control CNC system. The chips of each layer were cleaned with tap water and distilled water respectively, and the remaining fingerprints, oil stains and other stains on the surface of the chip were wiped with ethanol. On the double-sided adhesive film, the required microstructures and microchannels were processed with a cutting machine. The two-layer chip is carefully aligned, glued, and pressure-sealed to make a smart microvalve based on a microfluidic chip. The sample solution is added to the injection hole of the microfluidic chip, and the solution enters the microchannel driven by the external peristaltic pump. In the microvalve area of ​​the microchannel, the light-responsi...

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Abstract

The invention relates to a photo-response micro-fluid self-driven micro-fluidic chip and a preparation method thereof. The surface of the micro-fluidic chip is provided with a micro-structure and a micro-channel, the surface of the micro-channel is modified through photo-response molecules, reversible changes of the surface appearance of the micro-channel and chemical configurations cause surface wettability to change under visible light stimulation, and micro-fluids are controlled to move on the surface of the micro-channel from the bottom up, so that spontaneous flow of the micro-fluids is achieved, and the micro-fluidic chip is mainly applied to related fields of electrophoretic separation, chromatographic separation, immunoassays, reactions and the like. The micro-fluidic chip is simple to operate, self-driving of the micro-fluids from the bottom up is achieved, the cost of micro-fluid driving is greatly reduced, the micro-fluidic chip has the advantages of being portable, economical, rapid and efficient, and a novel micro-fluid flow control technology is provided for non-driving flow of micro-fluids.

Description

technical field [0001] The invention relates to a light-responsive microfluidic self-driven microfluidic chip and a preparation method thereof. The microfluidic chip has microstructures and microchannels on its surface, and the surface of the microchannel is modified by light-responsive molecules. Under the circumstances, the reversible change of the surface morphology and chemical configuration of the microchannel leads to the change of the surface wettability, which controls the movement of the microfluid from the bottom to the top of the microchannel surface, thereby realizing the spontaneous flow of the microfluid, which is mainly used in electrophoretic separation , chromatographic separation, immunoassay, reaction and other related fields. Background technique [0002] As a new type of analysis platform, microfluidic analysis chip has the advantages of miniaturization, automation, integration, convenience and speed, and has been widely used in many fields, such as cell...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 聂富强王晓东沙俊叶嘉明
Owner SUZHOU WENHAO MICROFLUIDIC TECH CO LTD
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