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Background interference elimination method for UV visible absorption spectrum of optical fiber in situ drug dissolution/releasing rate tester

A technology of absorption spectrum and dissolution rate, applied in the measurement of color/spectral characteristics, etc., can solve the problems of errors, inability to obtain UV-visible absorption spectrum, affecting the accuracy and reliability of analysis, etc.

Active Publication Date: 2015-03-11
上海富科思分析仪器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this traditional technology can only obtain a UV-Vis absorption spectrum without background interference elimination and the absorbance of several isolated feature points, and cannot obtain a corrected and can truly represent the absorbance of the analyte at each wavelength. UV-Vis Absorption Spectrum
Moreover, due to errors in the process of reading the feature point data and reference point data from the spectrogram, there are corresponding errors in the correction process of the corresponding background interference elimination, and this error is further calculated in each step of correction calculation. Therefore, there is a large error in the process of correcting the ultraviolet-visible absorption spectrum by the coefficient magnification method in the prior art, and this error is in the analysis of substances that need to be accurately measured, such as drug analysis, especially the dissolution rate of the drug dissolution process. / release analysis will greatly affect the accuracy and reliability of the corresponding analysis

Method used

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  • Background interference elimination method for UV visible absorption spectrum of optical fiber in situ drug dissolution/releasing rate tester
  • Background interference elimination method for UV visible absorption spectrum of optical fiber in situ drug dissolution/releasing rate tester
  • Background interference elimination method for UV visible absorption spectrum of optical fiber in situ drug dissolution/releasing rate tester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] The background interference elimination method of the ultraviolet-visible absorption spectrum of the optical fiber in-situ drug dissolution / release rate tester of the present invention comprises the following steps:

[0137] Step 1: The light source inputs light with a wavelength λ in the range of 200-1100 nm to the Y-shaped optical fiber;

[0138] Step 2: The Y-shaped optical fiber transmits the light with a wavelength λ range of 200 to 1100 nm into the blank solution in the dissolution apparatus through the probe at the end of the Y-shaped optical fiber, and then uses the probe to collect the optical signal, and passes the obtained optical signal through the Y Type optical fiber to transmit it to the detection module;

[0139] The optical signal of the obtained blank solution is sequentially input into the grating spectroscopic module, the photodiode array module, the signal amplification module and the analog-to-digital converter, and the digital signal of the optica...

Embodiment 2

[0159] For Example 1, the acquisition process of the light intensity spectrum data of the blank solution and the solution to be tested was improved. The background interference elimination method of the ultraviolet-visible absorption spectrum of the optical fiber in-situ drug dissolution / release rate tester of the present invention comprises the following steps:

[0160] Step 1: The light source inputs light with a wavelength λ in the range of 200-1100 nm to the Y-shaped optical fiber;

[0161] Step 2: generate the light intensity spectrum information of the blank solution, which further includes the following steps:

[0162] Step 2.1: The Y-shaped optical fiber transmits light with a wavelength λ range of 200 to 1100 nm into the blank solution in the dissolution apparatus through the probe at its end, and then uses the probe to collect optical signals, and passes the obtained optical signals through Y Type optical fiber to transmit it to the detection module;

[0163] Step ...

Embodiment 3

[0182] Step 5 in Example 2 is improved in the following manner, and other steps remain unchanged.

[0183] In the step 5, the standard ultraviolet-visible absorption spectrum of the auxiliary material is transferred from the microprocessor as the ultraviolet-visible absorption spectrum of the auxiliary material solution, thereby obtaining the absorbance A at a plurality of one-to-one corresponding different wavelengths λ of the auxiliary material solution 辅料 .

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Abstract

One purpose of the invention is to disclose a background interference elimination method for a UV visible absorption spectrum. With the method, correction can be carried out on absorbance at any wavelength in a spectrum chart to eliminate background interference so as to obtain a complete UV visible absorption spectrum with eliminated background interference, and errors are minimized in the process of correction; thus, the method is particularly applicable to the field of substance analysis in need for accurate determination, especially to analysis of a dissolution / releasing rate of a drug in the process of dissolution. The background interference elimination method disclosed in the invention is particularly applicable to an optical fiber in situ drug dissolution / releasing rate tester to eliminate background interference brought by other substances in a solution to be tested so as to obtain a real-time concentration curve of a to-be-tested substance, especially to obtain a concentration-time curve of a dissolution / releasing rate of a solid drug preparation (a tablet, a capsule, etc.).

Description

technical field [0001] The invention relates to a method for eliminating background interference of ultraviolet-visible absorption spectrum, in particular to a method for eliminating background interference of ultraviolet-visible absorption spectrum acquired by an optical fiber in-situ drug dissolution / release rate tester. Background technique [0002] The coefficient magnification method is a quantitative spectral analysis method based on the principle of ultraviolet-visible absorption spectrum. It is a method to calculate the concentration of a certain component in the mixture according to the ultraviolet-visible absorption spectrum of the mixture, and is used to eliminate the excipients in the process of determining the dissolution of drugs. caused interference. [0003] During the dissolution process of the solid drug preparation, the drug excipients are also dissolved along with the active ingredients of the drug. Therefore, the absorption spectrum obtained directly thr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/33
Inventor 胡旭王良玉张奇洲李华西李新霞李翔
Owner 上海富科思分析仪器有限公司