Bilayer tablet comprising telmisartan and amlodipine
A technology of telmisartan and amlodipine, which can be used in medical preparations containing active ingredients, pill delivery, metabolic diseases, etc., can solve problems such as incompatibility and stability, and achieve a solution to promote dissolution and solve stability problems. Effect
Inactive Publication Date: 2013-05-08
BOEHRINGER INGELHEIM INT GMBH
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- Abstract
- Description
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- Application Information
AI Technical Summary
Problems solved by technology
The tablet structure also solves the stability problem caused by the incompatibility of the basic components of amlodipine and telmisartan
Method used
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Experimental program
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Effect test
Embodiment 1
[0106] Example 1: Telmisartan 80mg / Amlodipine 10mg 2-layer tablet
[0107]
[0108] *Volatile components will not remain in the final product
Embodiment 2
[0109] Example 2: Telmisartan 80mg / Amlodipine 5mg 2-layer tablet
[0110]
[0111] *Volatile components will not remain in the final product
Embodiment 3
[0112] Example 3: Telmisartan 80 mg / Amlodipine 2.5 mg 2-layer tablet
[0113]
[0114] *Volatile components will not remain in the final product
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A bilayer tablet comprises a first layer formulated for instant release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix and a second layer formulated for instant release of the calcium channel blocker amlodipine from a disintegrating or eroding tablet matrix.
Description
[0001] This application is a divisional application of the Chinese invention application (invention name: bilayer tablet containing telmisartan and amlodipine; filing date: October 29, 2005; application number: 200580033928.9). [0002] The present invention relates to a first layer comprising the angiotensin II receptor antagonist telmisartan in a dissolving tablet matrix and a second layer of the calcium ion channel blocker amlodipine in a disintegrating or eroding tablet matrix. Layers of medicine tablets. Background of the invention [0003] As disclosed in EP-A-502314, Telmisartan is an angiotensin II receptor antagonist developed for the treatment of hypertension and other medical indications. Its chemical name is 4'-[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-ylmethyl]- Biphenyl-2-carboxylic acid; [0004] [0005] Telmisartan is manufactured and supplied in the free acid form. It is characterized by very poor solubility in aqueous systems of...
Claims
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IPC IPC(8): A61K31/4422A61K31/4184A61K9/24A61P9/12A61P9/10A61P9/04A61P9/00A61P3/10A61P13/12A61P3/00A61P3/04A61P3/06A61P25/28
CPCA61K9/2013A61K31/455A61K9/2077A61K9/2059A61K9/2054A61K9/209A61K9/2018A61K9/2009A61K31/4184A61K31/4422A61P13/12A61P25/00A61P25/28A61P3/00A61P3/10A61P3/04A61P3/06A61P3/08A61P43/00A61P9/00A61P9/04A61P9/08A61P9/10A61P9/12A61K2300/00
Inventor 沃尔弗拉姆.艾森赖克
Owner BOEHRINGER INGELHEIM INT GMBH