Novel 6,7-disubstituted-isoquinoline derivatives and their use
A technology of dihydroisoquinoline and medicine, which can be applied to medical preparations containing active ingredients, pharmaceutical combinations, active ingredients of heterocyclic compounds, etc., and can solve problems such as high concentration
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Embodiment 1
[0069] 6,7-Difluoro-1-methyl-3,4-dihydroisoquinoline
[0070] 1H NMR(CDCl3): δppm 7.450(3,1H,d,J=4.858), 2.277(6,3H), 3.647(8,1H,ddd, J=13.253, J=9.980, J=3.970), 3.848 (8,1H,ddd,J=13.253,J=3.860,J=1.950),3.019(9,1H,ddd,J=14.326,J=3.970,J=1.950),2.849(9,1H,ddd,J =14.326,J=9.980,J=3.860), 7.260(11,1H,d,J=4.858). The boiling point is 112-116°C at 10mmHg.
Embodiment 2
[0072] 1-Methyl-4,6,7-trifluoro-3,4-dihydroisoquinoline
[0073] 1H NMR(CDCl3): δppm 7.493(3,1H,d,J=5.422), 2.238(6,3H), 3.886(8,1H,dd,J=13.927,J=3.970), 3.943(8,1H) ,dd,J=13.927,J=1.960), 5.884(9,1H,dd,J=3.970,J=1.960), 7.763(12,1H,d,J=5.422). The boiling point is 118-122°C at 10mmHg.
Embodiment 3
[0075] 4,6,7-Trifluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline
[0076] 1H NMR(CDCl3): δppm 7.466(3,1H,d,J=5.020), 3.930(5,1H,q,J=6.684), 1.213(6,3H,d,J=6.684), 3.065(8 ,1H,dd,J=14.188,J=3.650), 3.089(8,1H,dd,J=14.188,J=2.050), 5.788(9,1H,dd,J=3.650,J=2.050), 7.602( 12,1H,d,J=5.020). The boiling point is 108-113°C at 10mmHg.
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