Method for building mouse severe aplastic anemia model
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- AFFILIATED HOSPITAL OF NANTONG UNIV
- Publication Date
- 2013-07-03
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
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Abstract
Description
technical field
[0001] The invention relates to a method for a bone marrow failure disease model, in particular to a method for establishing a severe aplastic anemia model in mice. Background technique
[0002] At present, most researchers at home and abroad use mice to establish mouse models of severe aplastic anemia to study the pathogenesis of aplastic anemia. The methods for inducing severe aplastic anemia mouse models mainly include chemical methods, physical methods, immune-mediated methods and mixed methods. The modeling time period of the chemical method is long and unstable; the model of the physical method will damage the organs of the whole body; the hematopoietic function of the mixed method will return to normal on its own at about 25 days, so the model induced by physical or chemical factors is not suitable for aplastic disorders Anemia research. The immune-mediated aplastic anemia model has good stability and is closer to the human immune-mediated bone marro...