Traditional Chinese medicine extract and preparation method thereof

A technology of extracts and natural medicines, used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of patients with dehydration, acid-base balance disorders, malnutrition, etc., to increase the inhibitory effect, enhance the inhibitory effect, and good side effects. Effect

Inactive Publication Date: 2013-08-07
张宗升
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AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, etc., the incidence of chemotherapy-related diarrhea has increased year by year, and if active treatment is not carried out, it is easy to cause Dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc. in patients not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Therefore, effective treatment of chemotherapy-related diarrhea has become a An important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Traditional Chinese medicine extract and preparation method thereof
  • Traditional Chinese medicine extract and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment approach

[0034] The first step: preparation of various extracts

[0035] (1) Preparation of the concentrated extract of radish seed and yam water decoction

[0036] According to the compatibility ratio of 1-4:1, take radish and yam, soak in distilled water for 1 hour, heat and decoct, filter with silk cloth, add 6 times of distilled water to the medicine residue, soak, decoct and filter in the same way, mix the two filtrates, Heat and concentrate to a small volume, filter with an ultrafiltration membrane, and dry under reduced pressure at 70°C to obtain the obtained product.

[0037] (2) Preparation of Raphanusin

[0038] Grind radish seeds and add excess n-hexane to degrease, enzymatically hydrolyze with pH 7.0 phosphate buffer, add dichloromethane to extract 3 times, combine solvents, remove organic solvent under reduced pressure, and dissolve the residue with 10% ethanol solution by volume fraction, Extract with n-hexane for 3 times to remove grease, then extract the ethanol phase...

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Abstract

The present invention relates to a nature drug composition, a preparation method and uses of the nature drug composition in preparation of attenuation synergism drugs in cancer chemotherapy. The nature drug composition comprises an extract, raphanin, a common yam rhizome ethanol extract and a common yam rhizome polysaccharide according to a ratio of 2-:2-5:5-9:1-4, wherein garden radish seed and common yam rhizome are subjected to water decoction concentration to obtain the extract. The composition provides good treatment effects for diarrhea related to cancer chemotherapy, and provides synergism effects for cancer chemotherapy.

Description

technical field [0001] The present invention relates to a kind of natural medicine composition, more specifically relate to a kind of natural medicine composition which is composed of radish seed yam water decoction concentrated extract, radishin, yam ethanol extract and yam polysaccharide, the natural medicine composition The preparation method and the application of the natural medicine composition in the preparation of medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs used alone or in combination can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy is also called chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P1/12A61P35/00A61K31/715A61K31/26
Inventor 张宗升
Owner 张宗升
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