A kind of active part of Schisandra chinensis for improving sleep and preparation method thereof

An active part, sleep-improving technology, applied in the field of medicine and health care products, to achieve good repeatability, facilitate industrial production, and increase compliance

Active Publication Date: 2014-10-15
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few research reports on the sedative and hypnotic active parts of Schisandra chinensis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Take Schisandra chinensis medicinal material, add 8 times of 95% ethanol to extract twice, each time for 2 hours, combine the two extracts, filter, concentrate under reduced pressure to obtain extract, add water to suspend, add petroleum ether to extract 1~3 times, recover the petroleum ether extract to obtain the petroleum ether extraction part, add chloroform for extraction 1 to 3 times, reclaim the chloroform extract to obtain the chloroform extraction part, add ethyl acetate to extract 1 to 3 times, reclaim the ethyl acetate extract to obtain ethyl acetate Extraction site. The ethyl acetate layer solvent was evaporated to obtain the active part of Schisandra chinensis.

Embodiment 2

[0027] Example 2: Take Schisandra chinensis medicinal material, add 10 times of 95% ethanol to extract twice, each time for 2 hours, combine the two extracts, filter, concentrate under reduced pressure to obtain extract, add water to suspend, add petroleum ether to extract 1~3 times, recover the petroleum ether extract to obtain the petroleum ether extraction part, add chloroform for extraction 1 to 3 times, reclaim the chloroform extract to obtain the chloroform extraction part, add ethyl acetate to extract 1 to 3 times, reclaim the ethyl acetate extract to obtain ethyl acetate Extraction site. Evaporate the solvent in the ethyl acetate layer to obtain the active part of Schisandra chinensis.

Embodiment 3

[0028] Example 3: Take Schisandra chinensis medicinal material, add 8-10 times of 35-95% ethanol to extract twice, each time for 2 hours, combine the two extracts, filter, concentrate under reduced pressure to obtain extract, add water to suspend, add petroleum ether Extract 1-3 times, recover the petroleum ether extract to obtain the petroleum ether extraction part, add chloroform to extract 1-3 times, recover the chloroform extract to obtain the chloroform extraction part, add ethyl acetate to extract 1-3 times, recover the ethyl acetate extract Ethyl acetate extraction site was obtained. Evaporate the solvent in the ethyl acetate layer to obtain the active part of Schisandra chinensis.

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PUM

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Abstract

The invention belongs to the field of medicine, and relates to an active part isolated from the dried mature fruit of Schisandra chinensis (Turcz.) Baill., a plant of Magnoliaceae, in particular to a preparation method of the active part of Schisandra chinensis with hypnotic effect. And through the subthreshold sleep dose and suprathreshold sleep dose of pentobarbital sodium induced mice sleep number and sleep time, the results showed that the active site of Schisandra can increase the subthreshold dose of pentobarbital sodium induced mice The number of mice falling asleep can obviously prolong the sleep time of mice induced by suprathreshold dose, and has obvious hypnotic activity.

Description

technical field [0001] The invention belongs to the field of medicine and health care products, and relates to the traditional Chinese medicine Schisandra chinensis, in particular to a preparation method of the active part of Schisandra chinensis with sedative and hypnotic effects. Background technique [0002] At present, the global incidence of insomnia is increasing year by year. Long-term insomnia not only damages people's thinking activities, but even affects people's immune system. Clinically, chemical drugs with sedative and hypnotic effects are commonly used to treat insomnia, but these drugs are limited in application because of their side effects and addiction. Studies have shown that many traditional Chinese medicine ingredients have good sedative and hypnotic effects, and have few adverse reactions, so they have good research and development application prospects. However, due to the ambiguity of the effective part of the traditional Chinese medicine preparation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61P25/20A61K131/00
Inventor 贾英毕开顺李清范旭航沈旭崔思娇
Owner SHENYANG PHARMA UNIVERSITY
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