A preparation method for bionic mussel glue based on oxetane derivatives

A technology of oxetane and its derivatives, which is applied in the field of preparation of bionic mussel glue, can solve the problems of high biocompatibility and high adhesion strength of bionic mussel glue, which is difficult to achieve unification, and achieves a simple, efficient and good synthesis method. Biocompatibility, the effect of breaking through technical bottlenecks
CN103289074BInactive Publication Date: 2016-02-17QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
Publication Date
2016-02-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention involves a preparation method based on the oxygen cycle -borne derivatives synthetic bionic mussel glue. The main steps are: using two types of oxygen cytane derivatives to open the co -phenolic hydroxyl group to be protected with child teaThe polymer of the phenol -side chain structure, which is protected by the polymer to obtain a polymer containing a phenyl phenol structure. After dissolving, add a certain amount of cross -linked agent and stir evenly.It is characterized by: 1) This synthesis method is simple and efficient, and the raw materials and reagents used in the reaction process are cheap and easy to obtain, and the easy operation process and realize industrial production;The simulation of high molecules of natural mussel adhesion protein properties to achieve a certain purpose of a certain biocompatibility and unified high adhesion intensity is a new type of bionic mussels synthesis technology.New bionic polymer materials for effective protein ingredients provide new ways.
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Description

technical field

[0001] The invention relates to a method for preparing bionic mussel glue, in particular to a method for preparing bionic mussel glue with higher strength and better biocompatibility by using oxetane derivatives. Background technique

[0002] Mussels have a strong adhesive ability, and the adhesive protein secreted by them can adhere to almost all substrate materials, even including polytetrafluoroethylene, and this natural adhesion does not exist in the underwater or wet environment of synthetic adhesives. Defects with poor performance, and will not cause human immune response, so it has a wide range of applications in waterproof sealants and adhesives in the field of national defense and marine engineering, and medical adhesives for bonding soft and hard tissues in the field of biomedicine. The application prospect has attracted much attention.

[0003] The study found that there is a large amount of 3,4-dihydroxyphenylalanine (DOPA) in the adhesion-relate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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