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Application of BST-2 protein in preparing medicaments for treating diseases caused by influenza A virus

A type of influenza A virus, BST-2 technology, applied in the application field of infection and release, can solve the problems of unseen influenza virus particle release and replication impact, etc.

Inactive Publication Date: 2013-09-18
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Influenza virus is also an enveloped virus, but there is no report on the effect of BST-2 on the release and replication of influenza virus particles

Method used

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  • Application of BST-2 protein in preparing medicaments for treating diseases caused by influenza A virus
  • Application of BST-2 protein in preparing medicaments for treating diseases caused by influenza A virus
  • Application of BST-2 protein in preparing medicaments for treating diseases caused by influenza A virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] experiment material

[0031] 1. Main instruments

[0032]

[0033] 2. Plasmid

[0034] 1) Influenza A virus (IAV) reverse genetic eight plasmid system according to literature (Hoffmann, E., et al., A DNA transfection system for generation of influenza A virus from eight plasmids.Proc Natl Acad Sci U S A, 2000.97 (11 ): p.6108-13), respectively: pHW181-PB2, pHW182-PB1, pHW183-PA, pHW184-HA, pHW185-NP, pHW186-NA, pHW187-M, pHW188-NS. The vectors used in this plasmid system are all pHW2000, and the viral cDNA is inserted between the RNA polymerase I (pol I) promoter and the terminator sequence; the transcription unit of pol I is located between the RNA polymerase II (pol II) promoter and the polyA sequence between. In cells, viral negative-strand RNA and mRNA can be synthesized, followed by viral protein synthesis, and finally assembled into infectious influenza virus particles.

[0035] 2) shRNA plasmids were purchased from Sigma

[0036]

[0037] 3) Plasmid pH...

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Abstract

The invention discloses an application of a BST-2 protein in preparing medicaments for treating diseases caused by influenza A virus. The BST-2 protein can inhibit IAV viral infection and prevent budding and releasing of the IAV virus from host cell surfaces through inhibiting expression of IAV virus M2 protein and interacting with the M2 protein. According to the invention, the BST-2 protein will become a new target for anti-influenza drugs, paves the way for research and development of the anti-influenza drugs in the future, and may even provide a potential therapeutic approach for treatment of the influenza.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of BST-2 in inhibiting the infection and release of influenza A virus. Background technique [0002] Influenza A virus is a common influenza virus that can cause outbreaks of seasonal and regional influenza. Influenza A virus has a wide range of hosts, including pigs, horses, leopards, marine mammals (seals, whales) and birds in addition to humans. The surface antigens HA and NA of influenza A virus are more likely to mutate, so it is easy to cause a large-scale epidemic. For example, the Spanish flu in 1918 was caused by influenza A virus (H1N1), causing about 20 million deaths. In 2009, the global epidemic caused by influenza A virus (H1N1) caused 18,500 deaths worldwide. Influenza A virus therefore poses a serious threat to public health worldwide. [0003] Influenza A Virus (IAV) belongs to the Orthomyxoviridae family and is an enveloped virus containing 8 segments ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61P31/16
Inventor 岑山
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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