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Terramycin injection for veterinary use

A technology of oxytetracycline and injection, applied in the direction of active ingredients of tetracycline, drug delivery, inorganic non-active ingredients, etc., can solve the problems of short duration of drug effect, inconvenience of high consistency, poor stability, etc., to reduce the number of medications, Good for injection and good fluidity

Inactive Publication Date: 2013-10-09
四川喜亚动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of low concentration, high consistency, inconvenient injection, poor stability, and short drug effect maintenance time of oxytetracycline injection in the prior art, and provide high concentration, low consistency, easy injection, and stability. Veterinary Oxytetracycline Injection with Better and Longer Efficacy

Method used

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  • Terramycin injection for veterinary use
  • Terramycin injection for veterinary use
  • Terramycin injection for veterinary use

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Embodiment 1 oxytetracycline injection for animals

[0036] Veterinary oxytetracycline injection, it is prepared like this: get water for injection 150ml, add 3g sodium sulfite, stir until fully dissolving; Add 400ml2-pyrrolidone, 150ml glycerin formal, 50ml propylene glycol, stir; Add 96g magnesium carbonate, Stir evenly so that the solution temperature is within the range of 55°C-60°C; slowly add 330g of oxytetracycline base, stir while adding, and stir until uniform after adding; under nitrogen atmosphere, keep the solution temperature at 55°C-60°C , and keep stirring until a clear solution is obtained; then add 50ml Tween-80 and stir evenly; lower the temperature of the solution to 25°C-30°C, adjust the pH value to 8.8 with diethylamine, and finally stabilize the solution with water for injection Capacity up to 1000ml.

[0037] The prepared oxytetracycline injection was sealed and packaged in ampoules filled with nitrogen, with a specification of 10 mL / bottle, and ...

Embodiment 2

[0152] Embodiment 2 oxytetracycline injection for animals

[0153] Veterinary oxytetracycline injection, it is prepared like this: get water for injection 150ml, add 3g sodium sulfite, stir until fully dissolving; Add 400ml2-pyrrolidone, 120ml glycerin formal, 80ml propylene glycol, stir; Add 90g magnesium carbonate, Stir evenly so that the solution temperature is within the range of 55°C-60°C; slowly add 330g of oxytetracycline base, stir while adding, and stir until uniform after adding; under nitrogen atmosphere, keep the solution temperature at 55°C-60°C , and keep stirring until a clear solution is obtained; then add 40ml Tween-80 and stir evenly; reduce the temperature of the solution to 25°C-30°C, adjust the pH value to 8.8 with diethylamine, and finally stabilize the solution with water for injection Capacity up to 1000ml.

[0154] Of course, during the preparation of the oxytetracycline injection for veterinary use in this example, the pH value can also be adjusted t...

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Abstract

The invention discloses terramycin injection for veterinary use. The terramycin injection for veterinary use is particularly prepared in the following steps: adding 3 g of sodium sulfite into 150 ml of water for injection and stirring until the sodium sulfite is completely dissolved; adding 400 ml of 2-pyrrolidone, 150 ml of glycerolformal and 50 ml of propylene glycol and stirring uniformly; adding 96 g of magnesium carbonate and stirring uniformly, the solution temperature is kept between 55 and 60 DEG C; slowly adding 330 g of oxytetracycline while stirring, and stirring uniformly after all the oxytetracycline is added; maintaining the solution temperature to be 55 to 60 DEG C under the atmosphere of nitrogen, and stirring continuously until a clear solution is obtained; adding 50 ml of tween-80 and stirring uniformly; and reducing the solution temperature to be 25 to 30 DEG C, adjusting the pH value to be 8.5 by using diethylamine, and fixing the volume of the solution to be 1,000 ml by using the water for injection. The terramycin injection for veterinary use has good stability and has good flowability at low temperature; the maintaining time of blood concentration is long, so the drug use frequency is reduced; the injection dose for each time is small and is only half of the dose of the existing injection, so the cultivation cost of farmers is greatly reduced.

Description

technical field [0001] The invention relates to veterinary oxytetracycline preparations, in particular to veterinary oxytetracycline injections. Background technique [0002] Oxytetracycline injection has a relatively high consistency at low temperature, making injection more difficult; while at high temperature, the stability of oxytetracycline injection will deteriorate, destroying the active ingredient and thus reducing the efficacy. At present, when using oxytetracycline injection with poor stability, the drug efficacy is generally improved by increasing the dosage. At present, the oxytetracycline injection with longer drug effect has a concentration of 50-200 mg / ml and a dosage of 20 mg / kg. On the first day after injection, the activity of oxytetracycline in the body reaches the highest, which is 4-7ug / ml, the longest drug maintenance time in the body is 3 days, and the effective blood drug concentration maintenance time can only be maintained for 1-2 days; the number ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/65A61K47/02
Inventor 蒋勇吴刚
Owner 四川喜亚动物药业有限公司
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