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Misoprostol vaginal effervescent tablets and preparation method thereof

A technology for misoprostol and effervescent tablets, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low bioavailability and slow onset of action, and achieve The effect of low adverse reactions, rapid onset of action, and avoidance of side effects

Inactive Publication Date: 2013-10-09
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] One of the objects of the present invention is to provide a misoprostol vaginal effervescent tablet, which solves the problems of low bioavailability and slow onset of the current common misoprostol tablet

Method used

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  • Misoprostol vaginal effervescent tablets and preparation method thereof
  • Misoprostol vaginal effervescent tablets and preparation method thereof
  • Misoprostol vaginal effervescent tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Specification: Contains misoprostol 200μg / tablet

[0020]

[0021] The preparation process is as follows: Weigh misoprostol powder, microcrystalline cellulose, pregelatinized starch, citric acid, sodium bicarbonate, polyethylene glycol-6000, magnesium stearate, etc. according to the method of increasing in equal amounts, Sieve and mix evenly and directly compress into tablets.

[0022] Evaluation: The appearance is smooth, the hardness is moderate, the disintegration time is within 5 minutes, and the foaming volume is 5ml.

Embodiment 2

[0024] Specification: Contains misoprostol 200μg / tablet

[0025]

[0026]

[0027] The preparation process is as follows: Weigh misoprostol powder, microcrystalline cellulose, pregelatinized starch, citric acid, sodium bicarbonate, polyethylene glycol-6000, magnesium stearate, etc. according to the method of increasing in equal amounts, Sieve and mix evenly and directly compress into tablets.

[0028] Evaluation: The appearance is smooth, the hardness is moderate, the disintegration time is longer than 5 minutes, and it can be dispersed but not completely melted.

Embodiment 3

[0030] Specification: Contains misoprostol 200μg / tablet

[0031]

[0032] The preparation process is as follows: Weigh misoprostol powder, microcrystalline cellulose, sorbitol, pregelatinized starch, citric acid, sodium bicarbonate, polyethylene glycol-6000, magnesium stearate, etc. The method is sieved and mixed evenly, and then directly compressed into tablets.

[0033] Evaluation: The appearance is smooth, the hardness is moderate, the disintegration time is within 3-4 minutes, and the foaming volume is 3ml.

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Abstract

The invention belongs to the technical field of medicines, and relates to misoprostol vaginal effervescent tablets and a preparation method thereof. The misoprostol vaginal effervescent tablets have the effects of relaxing uterine smooth muscle, softening and expanding cervix uterus and promoting cervical ripening. The preparation is partially taken, is convenient to use, high in patient compliance, simple in production process and relatively low in preparation cost, and has obvious advantages.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a misoprostol vaginal effervescent tablet and a preparation method thereof. It can be used in many fields of obstetrics and gynecology, including medical abortion, cervical ripening for induction of labor, and preoperative softening and dilating of the cervix. Background technique [0002] Misoprostol was synthesized by British Searle Company in 1973, and it is an artificially synthesized active prostaglandin derivative. When it was first launched in 1985, the clinical indication of misoprostol was only to prevent and treat duodenal ulcer and gastric ulcer caused by non-steroidal anti-inflammatory drugs. Since 1990, it has been gradually applied in obstetrics and gynecology. Misoprostol stimulates cervical fibroblasts to accelerate the decomposition of cervical collagen by collagenase and elastase, or changes the arrangement of collagen fibers and increases the matrix...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/5575A61K47/38A61P15/04
Inventor 赵伟王红霞王伟平李化淋
Owner 天津市聚星康华医药科技有限公司
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