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Compound tilmicosin clathrate complex and preparation method thereof

A technology of tilmicosin and inclusion compound, which is applied in the field of compound tilmicosin inclusion compound and its preparation, can solve the problems of curative effect and side effects that cannot be improved, and achieve improvement of growth, increase of dissolution rate, and treatment of asthma Effect

Active Publication Date: 2015-05-13
JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although unscientific compound prescriptions can enhance the curative effect, high levels of drug residues cannot be avoided. Except for slight changes in drug administration and drug absorption and distribution in the body, the sustained-release preparations still cannot be improved in terms of curative effect and side effects.

Method used

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  • Compound tilmicosin clathrate complex and preparation method thereof
  • Compound tilmicosin clathrate complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The compound tilmicosin inclusion complex consists of the following components in parts by weight: 19 parts of tilmicosin, 15 parts of wolfberry, 11 parts of mulberry, 3 parts of polyacrylic resin II, 2 parts of polyacrylic resin III, hydroxypropyl - 42 parts of β-cyclodextrin;

[0023] The specific preparation method is as follows:

[0024] Preparation of Lycium barbarum polysaccharide extract: Weigh Lycium barbarum, place it in an oven at 50°C for 40 minutes, take it out after drying, cool it to room temperature and crush it to 100 mesh, add 14 times the mass of Lycium barbarum with 90% ethanol at 60°C Heat and degrease in a water bath for 3 times, each time for 1.5h, filter and collect the filter residue and vacuum-dry to obtain a degreased powder, add water 17 times the mass of the degreased powder, then add cellulase with 0.7% of the mass of the degreased powder, and carry out microwave extraction at 350W for 20min After the extraction, heat in boiling water for 5...

Embodiment 2

[0030] The compound tilmicosin inclusion compound consists of the following components in parts by weight: 15 parts of tilmicosin, 12 parts of wolfberry, 7 parts of mulberry, 2 parts of polyacrylic resin II, 1 part of polyacrylic resin III, hydroxypropyl -26 parts of β-cyclodextrin;

[0031] The specific preparation method is as follows:

[0032] Preparation of Lycium barbarum polysaccharide extract: Weigh Lycium barbarum, place it in an oven at 45°C for 20 minutes, take it out after drying, cool it to room temperature and crush it to 100 mesh, add 12 times the mass of Lycium barbarum with 85% ethanol at 60°C Degrease by heating in a water bath for 3 times, 1 hour each time, filter and collect the filter residue and vacuum-dry to obtain a degreased powder, add water 15 times the mass of the degreased powder, then add cellulase with 0.5% of the mass of the degreased powder, and carry out microwave extraction at 300W for 15 minutes. After the extraction, heat in boiling water f...

Embodiment 3

[0038] The compound tilmicosin inclusion compound consists of the following components in parts by weight: 22 parts of tilmicosin, 18 parts of wolfberry, 13 parts of mulberry, 4 parts of polyacrylic resin II, 3 parts of polyacrylic resin III, hydroxypropyl - 50 parts of β-cyclodextrin;

[0039] The specific preparation method is as follows:

[0040] Preparation of Lycium barbarum polysaccharide extract: Weigh Lycium barbarum, place it in an oven at 55°C for 50 minutes, take it out after drying, cool it to room temperature and crush it to 100 mesh, add 16 times the mass of Lycium barbarum with 95% ethanol at 60°C Degrease by heating in a water bath 3 times, each time for 2 hours, filter and collect the filter residue and vacuum-dry to obtain a degreased powder, add water 20 times the mass of the degreased powder, then add cellulase with 0.8% of the mass of the degreased powder, and carry out microwave extraction at 400W for 30 minutes. After the extraction, heat in boiling wat...

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PUM

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Abstract

The invention discloses compound tilmicosin clathrate complex and a preparation method thereof. The compound tilmicosin clathrate complex is composed of tilmicosin, wolfberry, mulberry, polyacrylic resin II, polyacrylic resin III and hydroxypropyl-beta cyclodextrins. After pretreatment, the components are mixed into solid dispersion and are then included by cyclodextrin. The method provided by the invention is reasonable and scientific, and can effectively cure livestock poultry asthma and improve livestock appetite, thereby improving livestock weight increment accordingly.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound tilmicosin inclusion compound and a preparation method thereof. Background technique [0002] Tilmicosin is a semi-synthesized antibiotic for livestock and poultry by a hydrolyzate of tylosin, which has inhibitory effects on Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, spirochetes, etc.; Actinomyces pneumoniae and Pasteurella have stronger antibacterial activity than tylosin, and are mainly used to prevent and treat livestock pneumonia (caused by Actinobacillus pleuropneumoniae, Pasteurella, Mycoplasma, etc.), avian mycoplasma disease and lactating animals of mastitis. Tilmicosin belongs to macrolide antibiotics. Its specific 16-membered ring lactone structure can bind to the 50S subunit of bacterial ribosomes, act on the P site, inhibit the binding of transferase, and hinder the transfer of mRNA. position, so that the peptide bond cannot be shi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K36/605A61K47/48A61P31/04A61P11/06A61P1/14C08B37/00A61K31/706
Inventor 舒文林晏永新方学锋蔡美萍江润蓓张坤屈晓晟
Owner JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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