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Application of butylphthalide or derivatives thereof in preparation of medicaments for treating or preventing radiation brain damage

A technology of radiation brain injury and derivatives, applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems of low success rate, high risk and high cost of craniotomy

Inactive Publication Date: 2013-10-23
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, craniotomy has relatively high risk, low success rate and high cost
[0008] To sum up, the drug treatment methods for radiation brain injury in the prior art lack drugs with good curative effect, clear mechanism of action, and safe use, and there is an urgent need to expand alternative drugs for clinical selection

Method used

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  • Application of butylphthalide or derivatives thereof in preparation of medicaments for treating or preventing radiation brain damage
  • Application of butylphthalide or derivatives thereof in preparation of medicaments for treating or preventing radiation brain damage
  • Application of butylphthalide or derivatives thereof in preparation of medicaments for treating or preventing radiation brain damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 The protective effect of butylphthalide on the radiation damage of rat brain tissue

[0067] (1) Materials and methods

[0068] 1. Animals and grouping: 120 adult SD rats (provided by the Experimental Animal Center of Soochow University), with a mass of 200-250 g, were randomly divided into sham irradiation group, irradiation group, and butylphthalide group. The butylphthalide group was divided into 0.3 , 1.0, 3.0mg / kg groups, the observation time is 1d, 1 week and 1 month after irradiation, there are 15 groups in total, 8 rats in each group.

[0069] 2. Preparation and treatment of animal models: Rats were irradiated with a single 4 MeV electron beam generated by a Philips SL18 accelerator. For irradiation and dose measurement methods, see: Tian Ye, Bao Shiyao, Yin Weibo. Rat hemibrain irradiation early stage Study on changes of blood flow and water content in the brain. Chinese Journal of Radiation Oncology, 1999, 8:43-46. The absorbed dose rate is 210 ~2...

Embodiment 2

[0086] Example 2 Effect of butylphthalide on blood-brain barrier in rats with radiation-induced brain injury

[0087] (1) Materials and methods

[0088] 1. Animals and grouping: A total of 144 adult SD rats (provided by the Experimental Animal Center of Soochow University), weighing 200-250g, were randomly divided into blank control group, simple irradiation group (10Gy), simple butylphthalide group (1.0mg / kg), 0.3mg / kg butylphthalide combined with 10Gy irradiation group, 1.0mg / kg butylphthalide combined with 10Gy irradiation group, 3.0mg / kg butylphthalide combined with 10Gy irradiation group, the observation time was 1d, 1 week and 1 day after irradiation There were 18 groups in total, with 8 rats in each group.

[0089] 2. Preparation and treatment of animal models: Rats were irradiated with 4 MeV electron beams generated by Philips SL18 accelerator for a single shot. For irradiation and dose measurement methods, please refer to the literature: Tian Ye, Bao Shiyao, Yin W...

Embodiment 3

[0111] Example 3 Effect of butylphthalide on the expression of aquaporin 4 in the early brain cortex of rats after whole brain irradiation

[0112] (1) Materials and methods

[0113] 1. Animals and grouping: 96 adult SD rats (provided by the Experimental Animal Center of Soochow University), weighing 200-250 g, were randomly divided into blank control group, simple irradiation group, simple butylphthalide group, and butylphthalide combined irradiation group , the observation time was 1d, 1 week and 1 month after irradiation, there were 8 groups in total, 12 rats in each group.

[0114] 2. Preparation and treatment of animal models: Rats were irradiated with a single 4 MeV electron beam generated by a Philips SL18 accelerator. See literature for irradiation and dose measurement methods: Tian Ye, Bao Shiyao, Yin Weibo. Rat half brain after irradiation Study on the changes of blood flow and water content in the early brain [J]. Chinese Journal of Radiation Oncology, 1999, 8:43...

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Abstract

The invention discloses an application of butylphthalide or derivatives thereof in preparation of medicaments for treating or preventing radiation brain damage. The mechanism of action for treating the radiation brain damage by using the butylphthalide is that oxygen free radical balance in brain tissues subjected to radiation damage can be improved and the damage effect of oxygen free radicals can be relieved by the butylphthalide; the permeability of blood-brain barrier of a rat with radioactive brain damage can be reduced by reducing the number of circulating endothelial cells of the rat after whole brain irradiation, and the radioactive brain damage is protected, i.e., acting target cells of the butylphthalide are mainly vascular endothelial cells; and the AQP4 (Aquaporin 4) effect can be adjusted so as to protect the blood-brain barrier.

Description

technical field [0001] The invention relates to the field of medicine application, in particular to the application of butylphthalide or its derivatives in the preparation of medicines for treating or preventing radiation-induced brain injury. Background technique [0002] Radiation brain injury is a common complication after treatment of intracranial tumors, cerebrovascular malformations, and head and neck malignancies, which can lead to a decrease in the quality of life of patients. With the wide application of radiation techniques such as linear accelerator, X-knife, γ-knife, photon knife, and interstitial brachytherapy in clinical work, the incidence of radiation-induced brain injury has gradually increased. Clinically, this disease is easily ignored, or misdiagnosed as tumor metastasis or recurrence, which affects the early diagnosis and treatment of this disease. [0003] There is no unified conclusion on the pathogenesis of radiation brain injury. There are mainly th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/665A61K31/192A61P39/00A61P25/00
CPCA61K31/192A61K31/365A61K31/665
Inventor 陈应柱黄憗曹菊林常猇宇
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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