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Application of butylphthalide or its derivatives in preparation of drugs for treating radiation-induced brain injury

A technology for radiation brain injury and butylphthalide, applied in the field of drug use, can solve the problems of high cost, low success rate and high risk of craniotomy

Inactive Publication Date: 2017-07-21
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, craniotomy has relatively high risk, low success rate and high cost
[0008] To sum up, the drug treatment methods for radiation brain injury in the prior art lack drugs with good curative effect, clear mechanism of action, and safe use, and there is an urgent need to expand alternative drugs for clinical selection

Method used

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  • Application of butylphthalide or its derivatives in preparation of drugs for treating radiation-induced brain injury
  • Application of butylphthalide or its derivatives in preparation of drugs for treating radiation-induced brain injury
  • Application of butylphthalide or its derivatives in preparation of drugs for treating radiation-induced brain injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 The protective effect of butylphthalide on the radiation damage of rat brain tissue

[0065] (1) Materials and methods

[0066] 1. Animals and grouping: 120 adult SD rats (provided by the Experimental Animal Center of Soochow University), with a mass of 200-250 g, were randomly divided into sham irradiation group, irradiation group, and butylphthalide group. The butylphthalide group was divided into 0.3 , 1.0, 3.0mg / kg groups, the observation time is 1d, 1 week and 1 month after irradiation, there are 15 groups in total, 8 rats in each group.

[0067] 2. Preparation and treatment of animal models: Rats were irradiated with a single 4 MeV electron beam generated by a Philips SL18 accelerator. For irradiation and dose measurement methods, see: Tian Ye, Bao Shiyao, Yin Weibo. Rat hemibrain irradiation early stage Study on changes of blood flow and water content in the brain. Chinese Journal of Radiation Oncology, 1999, 8:43-46. The absorbed dose rate is 210 ~220...

Embodiment 2

[0084] Example 2 Effect of butylphthalide on blood-brain barrier in rats with radiation-induced brain injury

[0085] (1) Materials and methods

[0086] 1. Animals and grouping: A total of 144 adult SD rats (provided by the Experimental Animal Center of Soochow University), weighing 200-250g, were randomly divided into blank control group, simple irradiation group (10Gy), simple butylphthalide group (1.0mg / kg), 0.3mg / kg butylphthalide combined with 10Gy irradiation group, 1.0mg / kg butylphthalide combined with 10Gy irradiation group, 3.0mg / kg butylphthalide combined with 10Gy irradiation group, the observation time was 1d, 1 week and 1 day after irradiation There were 18 groups in total, with 8 rats in each group.

[0087] 2. Preparation and treatment of animal models: Rats were irradiated with 4 MeV electron beams generated by Philips SL18 accelerator for a single shot. For irradiation and dose measurement methods, please refer to the literature: Tian Ye, Bao Shiyao, Yin Wei...

Embodiment 3

[0109] Example 3 Effect of butylphthalide on the expression of aquaporin 4 in the early brain cortex of rats after whole brain irradiation

[0110] (1) Materials and methods

[0111] 1. Animals and grouping: 96 adult SD rats (provided by the Experimental Animal Center of Soochow University), weighing 200-250 g, were randomly divided into blank control group, simple irradiation group, simple butylphthalide group, and butylphthalide combined irradiation group , the observation time was 1d, 1 week and 1 month after irradiation, there were 8 groups in total, 12 rats in each group.

[0112] 2. Preparation and treatment of animal models: Rats were irradiated with a single 4 MeV electron beam generated by a Philips SL18 accelerator. See literature for irradiation and dose measurement methods: Tian Ye, Bao Shiyao, Yin Weibo. Rat half brain after irradiation Study on the changes of blood flow and water content in the early brain [J]. Chinese Journal of Radiation Oncology, 1999, 8:43-4...

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Abstract

The invention discloses application of butylphthalide or its derivatives in the preparation of drugs for treating radiation-induced brain injury and discloses an action mechanism of butylphthalide to treat radiation-induced brain injury. Butylphthalide can improve oxygen radical balance in radiation injured brain tissues, relieving the injury effect of oxygen radicals; butylphthalide can decrease the count of circulating endothelial cells after whole-brain radiation of rats, thereby reducing the permeability of blood-brain barrier in rats with radiation-induced brain injury, and protecting the rats from radiation-induced brain injury, i.e., butylphthalide mainly targets at vascular endothelial cells; butylphthalide can adjust AQP4 action to protect from blood brain barrier.

Description

technical field [0001] The invention relates to the field of medicine application, in particular to the application of butylphthalide or its derivatives in the preparation of medicines for treating or preventing radiation-induced brain injury. Background technique [0002] Radiation brain injury is a common complication after treatment of intracranial tumors, cerebrovascular malformations, and head and neck malignancies, which can lead to a decrease in the quality of life of patients. With the wide application of radiation techniques such as linear accelerator, X-knife, γ-knife, photon knife, and interstitial brachytherapy in clinical work, the incidence of radiation-induced brain injury has gradually increased. Clinically, this disease is easily ignored, or misdiagnosed as tumor metastasis or recurrence, which affects the early diagnosis and treatment of this disease. [0003] There is no unified conclusion on the pathogenesis of radiation brain injury. There are mainly th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/665A61K31/192A61P25/00
CPCA61K31/192A61K31/365A61K31/665
Inventor 陈应柱黄憗曹菊林常猇宇
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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