Traditional Chinese medicine composition and its preparation method and use

A kind of composition, technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, its preparation and use

Inactive Publication Date: 2013-11-13
石强
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  • Abstract
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AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Traditional Chinese medicine composition and its preparation method and use

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Experimental program
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Embodiment approach

[0035] The first step: preparation of various extracts

[0036] (1) Preparation of the concentrated extract of Alisma longipinosa decocted in water

[0037] According to the compatibility ratio of 1-6:1, take Alisma and Piper longum, soak in distilled water, heat and decoct, filter, add distilled water to the medicine dregs, soak, decoct and filter in the same way, mix the two filtrates, heat and concentrate, and supernatant Membrane filtration, drying under reduced pressure, that is.

[0038] (2) Preparation of alisol terpene alcohol B acetate

[0039] Percolate Alisma coarse powder with 80% ethanol, recover ethanol to 10%, put the oily extract on a silica gel column, elute with petroleum ether-ethyl acetate at a volume ratio of 10:1, and then use a solvent ratio of 10 : 3 petroleum ether-ethyl acetate elution, thin-layer chromatography detection, collect fractions, obtain crystallization, and then use petroleum ether-ethyl acetate recrystallization, promptly obtains alisol...

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Abstract

The invention relates to a traditional Chinese medicine composition and its preparation method and use. The traditional Chinese medicine composition comprises rhizoma alismatis-fructus piperis longi water decoction concentrated extract, alisol B acetate, fructus piperis longi ethanol extract and piperine according to a ratio of 2-7: 1-5: 3-5. The traditional Chinese medicine composition has excellent curative effects on cancer chemotherapy-related diarrhoea and has cancer chemotherapy synergism.

Description

technical field [0001] The present invention relates to a kind of traditional Chinese medicine composition, more specifically relate to a kind of traditional Chinese medicine composition that is composed of water-decoction concentrated extract of Piper longum alisma, Alisma terpene alcohol B acetate, ethanol extract of Piper longum and piperine. The preparation method of the traditional Chinese medicine composition and the use of the traditional Chinese medicine composition in the preparation of medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs used alone or in combination can cause toxic and side effects such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K36/884A61P1/12A61P35/00A61K31/4525A61K9/20A61K9/48
Inventor 石强
Owner 石强
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