Autologous stem cell anti-aging technology with efficacy of resisting aging and prolonging life

An anti-aging and hematopoietic stem cell technology, applied in medical preparations containing active ingredients, animal cells, vertebrate cells, etc. The effect of enhancing vitality

Inactive Publication Date: 2013-11-13
林雄斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if it is measured by prolonging the life span of mammals, so far, humans have not yet developed a sa...

Method used

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  • Autologous stem cell anti-aging technology with efficacy of resisting aging and prolonging life
  • Autologous stem cell anti-aging technology with efficacy of resisting aging and prolonging life
  • Autologous stem cell anti-aging technology with efficacy of resisting aging and prolonging life

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: Multiple transplantation of plant and protein-induced hematopoietic stem cells into the tail vein improves the body function of SAMP8 rapidly aging mice and prolongs the lifespan of SAMP8 rapidly aging mice

[0063] Senescence accelerated mouse (SAM) is an inbred aging model mouse obtained by Professor Takeda of Kyoto University in Japan for more than 20 years, including SAMP (senescence accelerated-prone mouse, SAMP) and SAMR (senescence accelerated mouse). -resistant mouse, SAMR) two strains. After passing through the growth period (about 4 to 6 months old), SAMP8 rapidly exhibits aging characteristics: from reactivity, passive escape response, fur luster, fur roughness, hair loss, skin ulcers, eye damage, corneal opacity, Corneal ulcers, cataracts, kyphosis and many other special signs and manifestations related to aging are commonly used animal models for research on aging and anti-aging.

[0064] Experimental grouping design and hematopoietic stem cel...

Embodiment 2

[0080] Example 2: Using plant and protein-induced autologous hematopoietic stem cell tail vein transplantation to improve the vitality of nude mice and prolong the life span of nude mice

[0081] Balb / c nude mice lack thymus, and because there are only thymus remnants or abnormal epithelium, T cells cannot differentiate normally, so T cells are immune deficient and have a limited lifespan. Due to the susceptibility to severe infection, nude mice can only be raised and survived in a very clean (SPF grade for short) environment. Hematopoietic stem cells are the origin of all blood cells and immune cells. In this study, autologous hematopoietic stem cells induced by plants and proteins were repeatedly transplanted intravenously, and the survival and lifespan of Balb / c nude mice were observed.

[0082] Experimental grouping design and stem cell transplantation method:

[0083] The same batch of 40 2-month-old Balb / c-nu nude mice was purchased from the Department of Experiment...

Embodiment 3

[0099] Example 3: Using plant and protein-induced autologous hematopoietic stem cell tail vein transplantation to delay the aging speed of natural aging Bal b / c mice and significantly prolong lifespan

[0100] 1. experimental method:

[0101] 1) Use the same batch of 60 12-month-old Balb / c mice, randomly group them into blank control group (20 mice), and PPiHPS experimental group (40 mice);

[0102] 2) 58 Balb / c mice aged 20 months in the same batch were randomly divided into blank control group (18 mice) and PPiHPS experimental group (40 mice);

[0103] For normal feeding, the blank group was injected with 0.1ml normal saline into the tail vein, once every 60 days; the experimental group was transplanted with 2x 10 tail veins. 7 PPiHPS, once every 60 days. All Balb / c mice in this experiment were purchased from the School of Radiology Medicine, Chinese Academy of Medical Sciences (Tianjin), animal certificate number: SCXK (Jin) 2010-0002.

[0104] 2. Production of don...

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Abstract

The invention provides a novel anti-aging and life-prolonging health care technology, which aims to realize organ function improvement, aging delay and life increase. The technology is realized through long-term multi-time transplantation of plants and proteins induced pluripotent stem cell (PPiHPS) to supplement seed cells required by growth, regeneration and restoration of body tissues and organs of individual life, and regeneratively restore ageing structures and functions of each part of individual life.

Description

technical field [0001] The present invention relates to the technical field of anti-aging medicine, anti-aging health care technology, regenerative medicine and restorative medicine, in particular, the present invention relates to a multiple transplantation of autologous hematopoietic stem cells (Plants and Proteins induced pluripotent Stem Cell) , anti-aging technologies and methods to delay aging, increase life expectancy and improve vital functions. Background technique Background technology one [0002] Health, longevity and longevity are the eternal needs of human life. Humans hope to overcome diseases, live a long and healthy life, and stay young forever. This is a beautiful wish pursued by human beings. [0003] In ancient times, generation after generation of emperors and generals longed for immortality, cultivating immortals, exorcising ghosts, and alchemy; Qin Shihuang sent Xu Fu to lead thousands of boys and girls into the East China Sea to find the elixir of li...

Claims

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Application Information

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IPC IPC(8): C12N5/0789A61K35/14A61P39/06A61L27/38A61K35/28
Inventor 林雄斌
Owner 林雄斌
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