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An antigen associated with rheumatoid arthritis

一种抗原、抗体的技术，应用在与类风湿性关节炎相关的抗原领域，能够解决未进行探索等问题

Active Publication Date: 2016-11-23
PHILOGEN SRL LLC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Antibody-based targeted delivery of bioactive agents to sites of vascularization is an attractive therapeutic strategy for cancer therapy but remains largely unexplored for chronic inflammatory diseases

Method used

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  • An antigen associated with rheumatoid arthritis
  • An antigen associated with rheumatoid arthritis
  • An antigen associated with rheumatoid arthritis

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Experimental program
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Embodiment Construction

[0059] name

[0060] Fibronectin

[0061] Fibronectin is an antigen that undergoes alternative splicing, and many alternative isoforms of fibronectin are known, as described elsewhere herein. Extra domain-A (EDA or ED-A) is also known as ED, extra type III repeat A (EIIIA) or EDI. The sequence of human ED-A has been published by Kornblihtt et al. (1984), Nucleic Acids Res. 12, 5853-5868 and Paolella et al. (1988), Nucleic Acids Res. 16, 3545-3557. The sequence of human ED-A is also available on the SwissProt database as amino acids 1631-1720 (fibronectin type III; extra domain 2) in the amino acid sequence deposited under accession number P02751. The sequence of mouse ED-A is also available on the SwissProt database as amino acids 1721-1810 (fibronectin type III; extra domain 2) in the amino acid sequence deposited under accession number P11276.

[0062] The ED-A isoform of fibronectin (A-FN) contains an extra domain-A (ED-A). The sequence of human A-FN can be deduced fr...

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Abstract

The present invention relates to an antigen associated with rheumatoid arthritis. The present invention relates to an antibody molecule that binds an extra domain‑A (ED‑A) isoform of fibronectin and / or ED‑A of fibronectin, comprising a VH domain and a VL domain, wherein the VH domain comprising the group of complementarity determining regions HCDR1, HCDR2 and HCDR3, and wherein the VL domain comprises the group of complementarity determining regions LCDR1, LCDR2 and LCDR3; wherein the antibody binds to a molecule having anti-inflammatory activity. The present invention relates to the detection and treatment of rheumatoid arthritis (RA).

Description

[0001] The present invention is a divisional application with the application date of October 27, 2008 and the title of "An Antigen Related to Rheumatoid Arthritis" Application No. 200880123186.2. technical field [0002] The present invention relates to the detection and treatment of rheumatoid arthritis (RA). The present invention relates to the use of binding members that bind the ED-A isoform of fibronectin, in particular binding members that bind the domain ED-A of fibronectin. Background technique [0003] Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects 0.5-1% of the population in the industrialized world and often results in significant disability with reduced quality of life. [0004] Angiogenesis in the synovium of patients with RA is considered an important early step in pathogenesis and disease persistence (Taylor, 2002). As in neoplastic disease, angiogenesis promotes dilation of the synovium (Walsh et al., 1998). ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K16/18C07K19/00C12N15/13C12N15/62C12N1/21C12N1/15C12N1/19C12N7/01C12N5/10C12P21/02
CPCA61K51/1018A61K2039/505C07K2317/21C07K2317/622C07K2317/92C07K2319/00A61K47/6813A61K47/6843C07K16/18A61P19/00A61P19/02A61P29/00C07K14/54
Inventor 曼努埃拉·卡斯帕凯瑟琳·施瓦格尔伊夫林·特拉赫塞尔
Owner PHILOGEN SRL LLC
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