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Phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid and preparation method thereof

An oral liquid, hypoglycemic technology, applied in the directions of pharmaceutical formulations, drug combinations, drug delivery, etc., can solve the problem of little research on the hypoglycemic effect of polysaccharides, and achieve the effects of alleviating the current shortage, simple process operation, and low cost and price.

Active Publication Date: 2014-12-10
福州市惠达天下生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are very few studies on the hypoglycemic effect of polysaccharides, and there are almost no reports on the polysaccharides of Phellinus mycelium polysaccharides fermented by Jujuncao solid fermentation. Traditional Chinese medicine compound also has the potential to lower blood sugar. Combined with the theory of traditional Chinese medicine compatibility, polysaccharides and traditional Chinese medicine compound are discussed. It is necessary to study the hypoglycemic activity of complexes with polysaccharides

Method used

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  • Phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid and preparation method thereof
  • Phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid and preparation method thereof

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Effect test

Embodiment 1

[0028] A preparation method of Phellinus polysaccharide and traditional Chinese medicine compound hypoglycemic oral liquid comprises the following steps:

[0029] (1) Solid fermentation of Phellinus:

[0030] A. Phellinus liquid preservation strains (preserved in the Food Biotechnology Laboratory of Fujian Agriculture and Forestry University) were activated and reconstituted, and cultured in a constant temperature shaker at 26°C at 110r / min for 5 days, and the secondary strain of the production shake flask was obtained after two expansion cultures ;

[0031] Activated medium formula: soybean flour 10 g / L, corn flour 20 g / L, wheat bran powder 1 g / L, yeast extract juice 1 g / L, KH 2 PO 4 0.1 g / L, ZnSO 4 ·7H 2 O 0.1 g / L, VB 1 0.1 g / L, pH natural;

[0032] B. Transfer the secondary species of the production shake flask into the Juncao solid medium for fermentation and cultivation for 25 days, and take out after the formation of the original base;

[0033] Juncao solid medi...

Embodiment 2

[0045] A preparation method of Phellinus polysaccharide and traditional Chinese medicine compound hypoglycemic oral liquid comprises the following steps:

[0046] (1) Solid fermentation of Phellinus:

[0047] A. Activate and compound Phellinus liquid-preserved bacterial strains, cultivate them in a constant temperature shaker at 30°C at 150r / min for 10 days, and obtain the secondary species of production shake flasks through two expansion cultures;

[0048] Activated medium formula: soybean flour 30 g / L, corn flour 40 g / L, wheat bran powder 10 g / L, yeast extract juice 10 g / L, KH 2 PO 4 1.0 g / L, ZnSO 4 ·7H 2 O 1.0 g / L, VB 1 0.1 g / L, pH natural;

[0049] B. Transfer the secondary species of the production shake flask into the Juncao solid medium for fermentation and culture for 40 days, and take out after the formation of the original base;

[0050] Juncao solid medium formula: Pentagrass 50 g / 100g, Jujuncao 15 g / 100g, Elephant grass 15 g / 100g, corn flour 15 g / 100g, bran...

Embodiment 3

[0062] A preparation method of Phellinus polysaccharide and traditional Chinese medicine compound hypoglycemic oral liquid comprises the following steps:

[0063] (1) Solid fermentation of Phellinus:

[0064] A. Activate and compound Phellinus liquid-preserved bacterial strains, cultivate them in a constant temperature shaker at 28°C at 130r / min for 7 days, and obtain the secondary species of production shake flasks through two expansion cultures;

[0065] Activated medium formula: soybean flour 20g / L, corn flour 30g / L, wheat bran powder 5g / L, yeast extract juice 5g / L, KH 2 PO 4 0.5 g / L, ZnSO 4 ·7H 2 O 0.5g / L, VB 1 0.1 g / L, pH natural;

[0066] B. Transfer the secondary species of the production shake flask into the Juncao solid medium for fermentation and culture for 30 days, and take out after the formation of the original base;

[0067] Juncao solid medium formula: 40 g / 100g of Miscanthus pentaphyllum, 10 g / 100g of Giant Juncao, 10 g / 100g of Elephant Grass, 12g / 100g...

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Abstract

The invention discloses phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid and a preparation method thereof. The preparation method comprises the following steps: performing giant fungus grass solid fermentation by taking phellinus igniarius liquid fungus as a primary fungus, so as to obtain a great amount of phellinus igniarius hypha; extracting phellinus igniarius polyose by adopting a hot water extraction method, removing impurities, carrying out alcohol precipitation, concentrating and freeze drying to obtain polyose powder; finally, mixing the polyose powder with a traditional Chinese medicine compound concentrated solution to prepare compounds with different doses. According to the invention, the technology is simple and convenient to operate, and is low in cost and price, safe and reliable, and suitable for the industrial large-scale production; the pharmacodynamics experiment on the phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering compound shows that the blood-glucose descending rate of a high dose group can reach up to 44.62%, so that the phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid has strong blood-glucose lowering effect.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to a compound oral liquid for lowering blood sugar and a preparation method thereof. Background technique [0002] Phellinus ( Phellinus igniarius (L.ex Fr.) Quel), which belongs to Basidiomycetes, Polyporacea, Polyporaceae, Acupunculus ( Phellinus ), commonly known as Phylophorus spp., Pyremus acubilis, Mulberry ear, Sang Chen, Hu Sun's eye, etc., is a precious medicinal fungus. The fungal polysaccharide isolated and extracted from the fruiting body, mycelium and fermentation broth of edible and medicinal fungi has the reputation of "biological response regulator", which can control the division and differentiation of cells, regulate the growth of cells, and has anti-oxidation and anti-virus properties. ﹑Anti-tumor ﹑lowering blood sugar ﹑improving immunity and other biological activities. Many studies have shown that certain polysaccharides with specific structur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/08C08B37/00A61P3/10A61K36/06
Inventor 刘斌廖尊胜陈颖赵超刘晓艳黄一帆
Owner 福州市惠达天下生物科技有限公司
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