32results about How to "Strong hypoglycemic effect" patented technology

The invention provides a tablet for assisting to reduce blood glucose and a preparation method. The tablet for assisting to reduce blood glucose comprises the following main raw materials in parts by weight: 100-130 parts of folium mori extract, 100-130 parts of bitter gourd extract, 30-60 parts of American ginseng extract, 50-100 parts of pseudo-ginseng extract, 50-100 parts of lucid ganoderma extract, 50-100 parts of astragalus membranaceus extract, and 8-15 parts of chromium-enriched yeast. The tablet for assisting to reduce blood glucose further comprises the following auxiliary materials in parts by weight: 150-200 parts of dextrin, 5-10 parts of magnesium stearate, and 10-15 parts of coating powder. According to the invention, the blood glucose of a diabetic patient is reduced by utilizing the complementarily synergistic effect of various components; and the tablet disclosed by the invention is also capable of reducing blood pressure, blood fat and blood viscosity, improving microcirculation to prevent peripheral neuropathy, improving ischemic and anaerobic states of brains and various tissues, increasing organism antioxygen ability, improving retinopathy, and increasing organism immunity.

The invention belongs to the technical field of health-care products, in particular to health-care tea for preventing diabetes. The health-care tea comprises raw materials in parts by weight as follows: 20 parts of dried guava barks, 2 parts of ginseng flower buds, 10 parts of dried miracle fruit leaves, 3 parts of peeled ganoderma and 65 parts of golden camellia fu-brick black tea. The preparation method includes steps as follows: the first four raw materials are crushed and subjected to sterilization and moisture absorption treatment by steam at the temperature of 122 DEG C for 10 minutes, the first four raw materials are cooled to 28 DEG C and mixed with the crushed and dispersed golden camellia fu-brick black tea, the mixture is fermented at the constant temperature of 28 DEG C and 18 DEG C day and night respectively and then dehumidified and dried at the constant temperature ranging from 50 DEG C to 52 DEG C, finally the mixture is packaged, and the health-care tea is obtained. The health-care tea has the characteristics that the tea can decrease blood sugar and is natural, free of side effects, mellow, sweet, convenient to store and carry and drinkable as long as brewed by boiled water.

The invention relates to a use of a szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of a drug for reducing blood sugar. Through massive screening and research, the inventor first finds the szechuan melandium root pentacyclic triterpenoid saponin compound extracted from a caryophyllaceae plant szechuan melandium root, purifies it and especially finds that a composition of a compound with sinocrassuloside as a mother nucleus and the szechuan melandium root pentacyclic triterpenoid saponin compound has strong blood sugar-reduction effects and can be used for preparation of anti-diabetic drugs.

The invention discloses a making method of separated and purified new bis-flavonoid from dragon's blood, which is characterized by the following: adopting dragon's blood as raw material; extracting through ligarine, acetone, acetic ester solvent sequently; separating and recrystallizing the acetic ester solvent extract through silica gel column or rapid silica gel column to chromatograph; obtaining the product named 8-(3-(4-hydroxy-2-methoxybenzene)-1-(4-hydroxy benzene) propyl )-2-(4-hydroxy phenyl )-7-methoxy -4H-benzopyranyl -4-ketone to inhibit alpha-glucosidase acitivty and reduce blood sugar.

The invention discloses a simple and convenient method for extracting blood glucose-reducing constituents from Hippophae rhamnoides leaves, belonging to the technical field of extraction of plant blood glucose-reducing constituents; the technical problem of difficulty in extraction of blood glucose-reducing constituents from the Hippophae rhamnoides leaves can be solved; and the adopted technical scheme is a simple and convenient method for extracting blood glucose-reducing constituents from Hippophae rhamnoides leaves. The method comprises the following steps of: fixing and drying the Hippophae rhamnoides leaves, then, smashing the dried leaves into coarse powder, adding water in an amount of 10-20 times of that of the coarse powder, boiling up, cooling to room temperature, and thereby obtaining precooked liquid of the Hippophae rhamnoides leaves; adding 1-5wt% of yeast according to mass of the precooked liquid, mixing evenly, preserving heat for 3-5 days at 26-36 DEG C; filtering the precooked liquid soaked under the condition of heat preservation, and drying the filter residue to get the Hippophae rhamnoides leaves powder for further use; carrying out reflux extraction to the Hippophae rhamnoides leaves powder with extracting solution according to a mass ratio of 5:1 of extracting solution to the Hippophae rhamnoides leaves powder, and performing reflux for 2-3 times; recycling the extracting solution by reduced pressure after reflux extraction, and obtaining the pasty Hippophae rhamnoides leaves extract.

The invention belongs to the technical field of tea processing, and particularly relates to a preparation process of dried orange pool golden-flower strip-shaped black tea with blood sugar reducing effect. The dried orange peel golden-flower strip-shaped black tea is prepared through the processes of spraying treatment of strip-shaped black tea, spraying treatment of dried orange peel, steaming, flower growing, drying and the like. The dried orange peel golden-flower strip-shaped black tea is uniform in distribution and large in number of golden flowers, integrates the fruit fragrance of dried orange peel, the mellow fragrance of tea and the fungus fragrance of golden flowers, and is rich and lasting in fragrance and rich and mellow in taste. Meanwhile, in the making process, the tea leaves do not need to be inoculated with eurotium cristatum manually, natural flower growing is directly carried out in a loose state without pressing, the making process is simple, the making process is stable, parameters are determined, repeatability and operability are high, the processed golden-flower tea is stable in quality, and the varieties of golden-flower tea in the market are enriched. In addition, compared with existing golden-flower Fuzhuan tea, the dried orange peel golden-flower strip-shaped black tea prepared by the preparation method disclosed by the invention has a stronger blood sugar reducing effect and can meet the requirements of consumers on health effects of tea products.

The invention relates to application of a Mongolian medicine Cymbaria n-butanol extract in the preparation of medicine for preventing and curing diabetes, and belongs to the field of medicine. The invention also discloses the application of the Mongolian medicine Cymbaria n-butanol extract in the preparation of medicine for preventing and curing diabetes, a preparation method of the Cymbaria n-butanol extract, and a medicine composition consisting of various carriers with acceptable active ingredients, excipients or diluents contained in the Cymbaria n-butanol extract. The research of pharmacological experiments shows that the Cymbaria n-butanol extract with the dose of 250 mg / kg has an effect of reducing the blood sugar of a mice suffering from diabetics induced by alloxan, has a higher hypoglycemic effect compared with a normal comparison group, and has a similar blood sugar reduction pharmacologic action as compared with a positive drug metformin hydrochloride group. The result of experiment research provides powerful experiment support for reasonable application of Cymbaria Mongolian medicinal materials.

The invention belongs to the technical field of health food, and in particular relates to a health tea tablet capable of preventing and treating diabetes and a preparation method of the health tea tablet. The health tea tablet is prepared from the following components in parts by weight: 16-24 parts of the fresh leaves of camellia nitidissima, 4-12 parts of the fresh leaves of aquilaria sinensis, 1-5 parts of unripe guava, 0.4-1.2 parts of the fresh leaves of green tea, 1-3 parts of cordyceps militaris, 0.6-1 part of artificially cultivated dendrobium officinale tender shoots, 0.4-0.6 part of food-grade eurotium cristatum solution, 0.2-0.4 part of saccharomyces cerevisiae, and 0.002-0.008 part of pullulan. The preparation method comprises the steps of fixation, extraction, fermentation, mixing, pressing, drying under reduced pressure and packaging. The prepared health tea tablet has the efficacies of obviously reducing blood sugar level, preventing and treating diabetes, and being good in flavor and taste.

The invention relates to effective parts of chicory seeds, process for preparation and usage, and the effective parts are new medicinal parts of chicory plant. Chicory seeds are directly extracted through employing low polar solvent or extracted, depressed and concentrated, and abstracted through employing high polar solvent, thereby obtaining effective antihypelipidemic parts of chicory seeds. Chicory seeds have the effect of antihepatotoxin according to bibliographical information. The effective parts extracted through the invention are proved by primary active screening test that the effective parts have the function of inhibitor of protein tyrosine phosphatase (PTP1B), and can be used as medicament for curing diabetes mellitus or applied in health care products, and meanwhile the effective parts can be applied as medicament composition.

The invention discloses a traditional Chinese prescription for treating hyperglycemia and a preparation method thereof. Calculated according to one-time oral dose of an adult who is 60kg in weight, the traditional Chinese prescription is prepared from the following crude drugs by weight: 10-20g of taibai bushy dasiphora leaf, 10-15g of glossy privet leaf, and 10-15g of persimmon leaf. Pharmacological tests show that the prescription has significant effect of reducing blood sugar, and is safe and innocuous.

The invention discloses a natural pharmaceutical composition for treating diabetic nephropathy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. Thenatural pharmaceutical composition for treating diabetic nephropathy comprises the following preparation raw materials by weight: 15-40 parts of polygonum capitatum extract, 10-35 parts of Chinese angelica extract, 12-26 parts of semen plantaginis extract and 5-8 parts of rhizoma curculiginisextract. The invention also discloses the preparation method of the natural pharmaceutical composition, the components of the natural pharmaceutical composition for treating diabetic nephropathy synergistically enhance the body immunity, control blood sugar, improve renal microcirculation, thereby achieving the purpose of treatment of diabetic nephropathy, the components have wide raw material sources and low cost, both symptoms and root causes are treated, and the curative effect is exact.

The invention belongs to the technical field of medicine and discloses a refining method of an effective part of bitter gourd for reducing blood sugar, comprising the steps that: (1) the bitter gourd medicine liquid is prepared before decoloring and refining: the decoction sheet of the bitter gourd is dried, crushed, extracted in an recycling manner by ethanol and concentrated to gain the extract; the extract is diluted, absorbed through big-pore absorbing resin column, washed, eluted with the ethanol solution to obtain the bitter gourd medicine liquid before decoloring and refining; (2) a refining process is carried out: the ethanol eluting solution of the resin column is collected and a discoloring agent is added , the mixing solution is heated and recycled, filtered, concentrated after reducing the pressure, dried in vacuum to obtain the steroidal glucoside of the bitter gourd. The steroidal glucoside of the bitter gourd extracted by the method of the invention can be directly made into various preparations, such as troche, capsule, grain, oral liquid, tablet, suspension, pill, cataplasma and paste, etc. Compared with the traditional technique, the invention is characterized by small volume, strong resistance against moisture and high content of the effective component. Compared with a solvent extracting method, the invention does not use organic toxic solvent which volatilizes easily in the technological flow, thus, the invention has safe and reliable operation, low production cost and no pollution to the environment.

The invention discloses a medicine for treating diabetes. The medicine comprises the following raw materials in percentage by weight: 11.1-15.1% of ginseng fruits, 11.1-15.1% of fragrant solomonseal rhizomes, 10.1-14.1% of kudzuvine roots, 10.1-14.1% of Chinese wolfberries, 10.1-12.1% of mulberry leaves, 9.1-13.1% of malt, 8.5-12.5% of astragalus roots, 8.5-12.5% of solomonseal rhizomes and 3.4-9.4% of coptis roots. According to the medicine for treating diabetes, through combination of the raw materials, immunity of organisms can be enhanced, virus infection can be resisted, and activity of the pancreas can be protected; normal metabolism of islet cells can be restored, and the secretion function of islet B cells can be improved; damaged islet B cells can be cultured for regeneration, insulin receptors can be enhanced, and the regulation effect of insulin can be fully exerted; trace elements closely related to diabetes can be highly supplemented; blood sugar and urine sugar can be rapidly reduced, and complications can be actively prevented and treated; and the health of diabetes patients can be comprehensively restored. The Tangshu capsule is only suitable for type II diabetes patients, is verified to have no toxic or side effects by toxicological experiments, is safe, convenient and reliable, has low dosage, is easily acceptable by patients, and has rapid and an obvious curative effect.

The invention provides fruit wine. The raw materials comprise vitis labrusca var and ganoderma lucidum. The invention further provides a preparing method of the fruit wine. The fruit wine is obtained by smashing the raw materials, mixing the materials and conducting fermentation at the temperature of 20-30 DEG C, and then filtering the fermentation product for 12-24 d. The fruit wine and the preparing method of the fruit wine have the advantages that the fruit wine of which nutritional contents can be given full play to is obtained, the most important nutritional contents in the ganoderma lucidum, namely ganoderma triterpenes cannot be decomposed, the synthesis of harmful byproduct sulfur dioxide can be inhibited at the same time, and the detects that symptoms of dyspnea, diarrhea, emesis and the like which can possibly be triggered when sulfur dioxide is taken for a long term and damages of different degrees to brains and other tissue may also occur when sulfur dioxide is taken for a long term are avoided.

The invention relates to a carbon glucoside sodium glucose transport protein body 2 inhibitor, a preparation method and an application of the inhibitor. The carbon glucoside sodium glucose transport protein body 2 inhibitor has a structure as shown in general formula (I) as shown in the specification.

The invention discloses a use of an amidation product of glycine and metformin in preparation of a drug for treating diabetes. Compared with the metformin hydrochloride-glycine combined drug, the amide derivative of glycine and metformin has better hypoglycemic effects and longer action time.

The invention discloses dendrobium nobile dark tea and a preparation method thereof. The dendrobium nobile dark tea comprises the following components in parts by weight: 30-45 parts of coarse dark tea, 10-15 parts of dendrobium officinale, 6-10 parts of codonopsis pilosula and 10-15 parts of black tartary buckwheat, and is prepared by the following steps: performing pile fermentation, adding lucid ganoderma bacteria, and performing secondary fermentation. According to the preparation method disclosed by the invention, the dendrobium officinale and the dark tea are organically combined, and the codonopsis pilosula and the black tartary buckwheat are reasonably matched, so that the formula has the effects of tonifying qi, nourishing yin, strengthening the spleen, nourishing the stomach andeffectively enhancing the immunity of organisms. The preparation method comprises the following steps: firstly, mixing raw material components of the dark tea, dendrobium officinale, codonopsis pilosula and black tartary buckwheat for primary pile fermentation, and then adding the lucid ganoderma bacteria for secondary microbial fermentation. Results show that the dendrobium nobile dark tea prepared by two times of fermentation shows strong lipid-lowering, weight-losing and blood sugar-lowering effects, and can effectively reverse abnormal glucose tolerance of patients at the early stage of diabetes mellitus.

The invention discloses a piceatannol oligomer, a preparation method therefor and an application of the piceatannol oligomer and belongs to the technical field of extraction, separation and purification of plant ingredients. A specific structural formula of the piceatannol oligomer is any one selected from structures as follows: formulae shown in the description. The invention further discloses the preparation method for the piceatannol oligomer and the application of the piceatannol oligomer. The piceatannol oligomer disclosed by the invention is derived from natural plants and is of a brand-new structure; a pair of new structural isomers can be formed through forming a five-membered ring by 7,8-site double bonds of cis-piceatannol and a phenolic hydroxyl group of epicatechin and are monopolymer derivatives of piceatannol; or a pair of new isomers with high-symmetrical structures are formed through forming a five-membered ring by 7,8-site double bonds of cis-(trans-)piceatannol and aphenolic hydroxyl group and are trimers of the piceatannol.

The invention provides a health food for people with diabetes, which comprises ebony meat, polygonatum polygonatum, kudzu root, sealwort, medlar, yam, spinach stem, green onion, mica slices, xylitol, and water as an auxiliary material. The present invention also provides a method for making the above-mentioned health food, which includes: processing raw materials, boiling the juice, filtering the filter residue, collecting the filtrate, continuing to boil until it becomes a viscous thick juice, and making candy. The invention uses ebony as the main raw material, which has the effects of anti-oxidation, clearing blood, increasing energy, protecting the digestive system, eliminating fatigue, preventing constipation, increasing appetite, etc. Not to mention people with diabetes, even normal people, regular consumption will also be harmful to the body. It is very beneficial, and the invention can not only obtain the effect of green onion, but also ensure the mouthfeel of candy, killing two birds with one stone.

The invention discloses phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid and a preparation method thereof. The preparation method comprises the following steps: performing giant fungus grass solid fermentation by taking phellinus igniarius liquid fungus as a primary fungus, so as to obtain a great amount of phellinus igniarius hypha; extracting phellinus igniarius polyose by adopting a hot water extraction method, removing impurities, carrying out alcohol precipitation, concentrating and freeze drying to obtain polyose powder; finally, mixing the polyose powder with a traditional Chinese medicine compound concentrated solution to prepare compounds with different doses. According to the invention, the technology is simple and convenient to operate, and is low in cost and price, safe and reliable, and suitable for the industrial large-scale production; the pharmacodynamics experiment on the phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering compound shows that the blood-glucose descending rate of a high dose group can reach up to 44.62%, so that the phellinus igniarius polyose and traditional Chinese medicine compound blood-glucose lowering oral liquid has strong blood-glucose lowering effect.

The invention belongs to the technical field of health-care products, in particular to health-care tea for preventing diabetes. The health-care tea comprises raw materials in parts by weight as follows: 20 parts of dried guava barks, 2 parts of ginseng flower buds, 10 parts of dried miracle fruit leaves, 3 parts of peeled ganoderma and 65 parts of golden camellia fu-brick black tea. The preparation method includes steps as follows: the first four raw materials are crushed and subjected to sterilization and moisture absorption treatment by steam at the temperature of 122 DEG C for 10 minutes, the first four raw materials are cooled to 28 DEG C and mixed with the crushed and dispersed golden camellia fu-brick black tea, the mixture is fermented at the constant temperature of 28 DEG C and 18 DEG C day and night respectively and then dehumidified and dried at the constant temperature ranging from 50 DEG C to 52 DEG C, finally the mixture is packaged, and the health-care tea is obtained. The health-care tea has the characteristics that the tea can decrease blood sugar and is natural, free of side effects, mellow, sweet, convenient to store and carry and drinkable as long as brewed by boiled water.

The invention relates to an application method of cyclic peptide compounds extracted from cortex lycii radicis. The method comprises the following steps of: continuously carrying out silicagel column chromatography on the cortex lycii radicis carbinol extractive, carrying out the polystyrene microporous resin crude separation and the inverse phase C18 silica gel column chromatography refining, and carrying out freeze drying to obtain four cyclic peptide compounds. The abdominally-dosed rat oral glucose tolerance test shows that the cyclic peptide compounds have the function of an insulin sample, and are higher in a blood sugar reducing effect. When the dose is 5mg / kg (weight), the inhibition ratio of the cyclic peptide compounds to the rise of the postprandial 2h blood sugar concentration of the diabetic rats induced by the streptozotocin can reach 76.5%, 67.4%, 65.8% and 69.3% respectively, therefore, the cyclic peptide compounds can be used for preparing the drug for treating diabetes or reducing blood sugar.

The invention discloses a repaglinide composite medicine and a preparation method thereof and belongs to the technical field of medicines. The medicine comprises, by mass, the following components: 1-5 parts of repaglinide, 1-3 parts of isopentobarbital, 2-5 parts of water-soluble dietary fiber, 0.2-0.5 part of glucose, 50-60 parts of a filler, 4-10 parts of a disintegrant, 1-3 parts of a binder and 1-3 parts of arginine. The preparation method comprises the steps of crushing, sieving, granulating, material wrapping preparation, material wrapping and granulating, forming and processing and thelike, and mainly comprises the steps of mixing glucose, a part of filler and a part of disintegrant to obtain core particles, and then wrapping other components, wherein a material wrapping and granulating device is adopted in the material wrapping and granulating operation, and the material wrapping and granulating device comprises a feeding and granulating mechanism, a wetting mechanism, a material wrapping mechanism and a discharging and granulating mechanism which are sequentially connected. The repaglinide composite medicine not only can provide a strong hypoglycemic effect, but also canprevent the possibility of increasing the side effect of hypoglycemia; the preparation method conforms to the requirement of drug action mechanism.

The present invention discloses a poa annua extract, an extraction method thereof and a use thereof as a hypoglycemic drug. The method comprises the following steps: pretreating poa annua, putting thepretreated poa annua into an extraction tank, also adding water and alcohol, conducting extraction by adopting a reflux extraction method, separating an extract, conducting concentration and drying,and evaluating hypoglycemic activity of the extract. The provided poa annua extract has a relatively strong hypoglycemic effect and is useful for preparing medicines for preventing or treating diabetes mellitus, metabolic syndromes, related diseases thereof, etc.

The invention relates to effective parts of chicory seeds, process for preparation and usage, and the effective parts are new medicinal parts of chicory plant. Chicory seeds are directly extracted through employing low polar solvent or extracted, depressed and concentrated, and abstracted through employing high polar solvent, thereby obtaining effective antihypelipidemic parts of chicory seeds. Chicory seeds have the effect of antihepatotoxin according to bibliographical information. The effective parts extracted through the invention are proved by primary active screening test that the effective parts have the function of inhibitor of protein tyrosine phosphatase (PTP1B), and can be used as medicament for curing diabetes mellitus or applied in health care products, and meanwhile the effective parts can be applied as medicament composition.

The invention discloses a method for extracting hypoglycemic components from seabuckthorn leaves, which belongs to the technical field of extracting plant hypoglycemic components; the technical problem to be solved is the difficulty in extracting hypoglycemic components from seabuckthorn leaves; The method for extracting the hypoglycemic component follows the following steps: after the leaves of seabuckthorn are de-enzymed and dried, they are crushed into coarse powder, added with water 10-20 times the weight of the coarse powder, boiled, and cooled to room temperature to obtain pre-boiled sea-buckthorn leaves; Add 1-5wt% Daqu to the quality of the cooking liquid, mix well, and keep warm at 26-36°C for 3-5 days; filter the pre-boiling liquid after soaking in heat preservation, and dry the filter residue to obtain seabuckthorn leaf powder, which is set aside; extract according to the mass ratio Solution: Seabuckthorn leaf powder = 5:1 Take the extract and carry out reflux extraction on the seabuckthorn leaf powder for 2-3 times; after reflux extraction, recover the extract under reduced pressure to obtain a paste-like seabuckthorn leaf extract.

The invention provides an oral medicament composition for treating diabetes and the complications of diabetes, belonging to the field of medicines. The oral medicament composition for treating diabetes and the complications of diabetes comprises migltol and heparin or low molecular heparin or a medicinal salt of the heparin or the low molecular heparin in the weight ratio of 1:0.1-9. The medicament composition plays a good synergic action on lowering blood sugar, can reduce the complications of diabetes and generate positive effect on the prognosis of a diabetic who takes the oral medicament composition for a long time so that the oral medicament composition for treating diabetes and the complications of diabetes is quite beneficial to the recovery of the diabetic.

The invention discloses a making method of separated and purified new bis-flavonoid from dragon's blood, which is characterized by the following: adopting dragon's blood as raw material; extracting through ligarine, acetone, acetic ester solvent sequently; separating and recrystallizing the acetic ester solvent extract through silica gel column or rapid silica gel column to chromatograph; obtaining the product named 8-(3-(4-hydroxy-2-methoxybenzene)-1-(4-hydroxy benzene) propyl )-2-(4-hydroxy phenyl )-7-methoxy -4H-benzopyranyl -4-ketone to inhibit alpha-glucosidase acitivty and reduce blood sugar.