Medicament composition for treating diabetes and complications of diabetes

A complication and composition technology, applied in the field of medicine, to achieve the effects of improving utilization, lowering blood sugar levels, and facilitating patients

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A complication and composition technology, applied in the field of medicine, to achieve the effects of improving utilization, lowering blood sugar levels, and facilitating patients

CN101584705BActive Publication Date: 2010-10-27LUNAN HOPE PHARM CO LTD

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Experimental program

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Effect test

Embodiment 1

[0018] prescription

[0019] Heparin Sodium 10g

[0020] Miglitol 100g

[0021] Microcrystalline Cellulose 250g

[0022] 8% hydroxypropyl methylcellulose solution appropriate amount

[0023] Low-substituted hydroxypropyl cellulose 120g

[0024] Magnesium Stearate 5g

[0025] Preparation process: pass through a 100-mesh sieve for heparin sodium and miglitol, pass through a 80-mesh sieve for microcrystalline cellulose and low-substituted hydroxypropyl cellulose, weigh the prescribed amount of heparin sodium, miglitol and low-substituted hydroxypropyl cellulose Mix plain and microcrystalline cellulose evenly, add 8% hydroxypropyl methylcellulose solution to granulate in appropriate amount, dry at 60°C, granulate with a 16-mesh sieve, add prescription amount of magnesium stearate to the dry granules, mix evenly, and press into tablets Instantly.

Embodiment 2

[0027] Heparin Sodium 450g

[0028] Miglitol 50g

[0029] Microcrystalline Cellulose 600g

[0030] PEG6% solution appropriate amount

[0031] Carboxymethyl Cellulose Calcium 255g

[0032] Magnesium Stearate 7.5g

[0033] Preparation process: with embodiment 1.

Embodiment 3

[0035] Low molecular weight heparin sodium 20g

[0036] Miglitol 100g

[0037] 400g pregelatinized starch

[0038] Sodium carboxymethyl cellulose 1% solution appropriate amount

[0039] Enteric coating powder appropriate amount

[0040] Carboxymethylcellulose Calcium 60g

[0041] Magnesium Stearate 4.5g

[0042] Preparation process: According to the conventional tablet process, it is made into tablets (ball cores) of required specifications, and then coated with enteric coating powder.

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Abstract

The invention provides an oral medicament composition for treating diabetes and the complications of diabetes, belonging to the field of medicines. The oral medicament composition for treating diabetes and the complications of diabetes comprises migltol and heparin or low molecular heparin or a medicinal salt of the heparin or the low molecular heparin in the weight ratio of 1:0.1-9. The medicament composition plays a good synergic action on lowering blood sugar, can reduce the complications of diabetes and generate positive effect on the prognosis of a diabetic who takes the oral medicament composition for a long time so that the oral medicament composition for treating diabetes and the complications of diabetes is quite beneficial to the recovery of the diabetic.

Description

technical field [0001] The invention relates to a new pharmaceutical composition for treating diabetes and its complications, which belongs to the field of medicine. Background technique [0002] Diabetes is an endocrine and metabolic disease, which is a disorder of carbohydrate metabolism caused by relative or absolute insufficiency of insulin in the body, causing sugar, protein, fat and secondary water and electrolyte metabolism disorders. Diabetes is clinically divided into two types: insulin-dependent diabetes (ie, type I diabetes), and non-insulin-dependent diabetes (ie, type II diabetes). Among them, the rate of type II diabetes is very high, accounting for about 90% of the number of people with diabetes. The harm of diabetes mainly comes from complications, and its incidence rate is very high, resulting in high mortality rate and high disability rate. Studies have shown that 30% to 40% of patients will develop at least one complication 10 years after the onset of di...

Claims

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Application Information

Patent Timeline

27 Oct 2010

Publication

CN101584705B

IPC: A61K31/727; A61K9/20; A61K9/22; A61K9/46; A61K9/48; A61P3/10; A61K31/445

Inventors: 赵志全