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Chicory seed effective part and preparation method and application thereof

A technology of effective parts and chicory seeds, which is applied in the field of effective parts of chicory seeds and its preparation and application, can solve the problems of unmentioned pharmacological action mechanism and lower blood uric acid level in model animals, etc.

Inactive Publication Date: 2010-12-22
新疆新绿宝药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liu Xiaoqing and others used a quail hyperuricemia model similar to human metabolism to prove that a small dose of chicory extract can significantly reduce the blood uric acid level of model animals. Chicory extract has a significant effect of lowering uric acid, but the pharmacological mechanism is not mentioned.

Method used

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  • Chicory seed effective part and preparation method and application thereof
  • Chicory seed effective part and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 (large polar solvent extraction)

[0032] Get the dry seed 10Kg of chicory, pulverize, place 50L extraction tank, extract 3 times with 70% ethanol room temperature (25 ℃) cold soaking, each time ethanol consumption is 30L, and each extraction time is 24 hours, combine extracts, Concentrate under reduced pressure in a rotary evaporator to dryness, add 2L of 10% methanol aqueous solution to dissolve, and extract 5 times with petroleum ether, 2L each time, combine the extracts, and concentrate to dryness in a rotary evaporator to obtain an oily sample The active part of CGS-1 is 148.5g.

Embodiment 2

[0033] Embodiment 2 (small polar solvent extraction)

[0034] Take 1Kg of dried chicory seeds, crush them, put them in a 10L extraction tank, and extract them by cold-soaking at room temperature with n-hexane for 3 times. Concentrate under reduced pressure in a rotary evaporator to dryness to obtain 41 g of the effective fraction of the oil.

Embodiment 3

[0035] Embodiment 3 (large polar solvent extraction)

[0036] Take 10Kg of dried chicory seeds, crush them, put them in a 50L extraction tank, extract 3 times with 10% methanol at a temperature of 70°C, the amount of methanol used for each time is 30L, and the extraction time is 24 hours each time. Concentrate to dryness under reduced pressure in the instrument, add 2L of 10% methanol aqueous solution to dissolve, and extract 5 times with gasoline, 2L each time, combine the extracts, and concentrate to dryness under reduced pressure in a rotary evaporator to obtain an oily sample CGS-1 effective Site 167g.

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Abstract

The invention relates to effective parts of chicory seeds, process for preparation and usage, and the effective parts are new medicinal parts of chicory plant. Chicory seeds are directly extracted through employing low polar solvent or extracted, depressed and concentrated, and abstracted through employing high polar solvent, thereby obtaining effective antihypelipidemic parts of chicory seeds. Chicory seeds have the effect of antihepatotoxin according to bibliographical information. The effective parts extracted through the invention are proved by primary active screening test that the effective parts have the function of inhibitor of protein tyrosine phosphatase (PTP1B), and can be used as medicament for curing diabetes mellitus or applied in health care products, and meanwhile the effective parts can be applied as medicament composition.

Description

technical field [0001] The invention relates to an effective fraction of chicory seeds and its preparation and use, in particular to the use of the effective fractions for hypoglycemia extracted from Chicory seeds in Xinjiang as medicine for treating diabetes and functional food. Background technique [0002] Chicory is a plant with a wide range of uses. Italian residents use chicory leaves to make vegetable salads, which are delicious. In addition, chicory has a lot of medicinal value. [0003] Chicory seeds, according to the Chinese Pharmacopoeia, "Chicory" seeds specifically refer to the dried seeds of Cichorium intybus L. or Cichorium glandulosum Bioss.et Huet. Cichorium glandulosum Boiss.et Huet and Cichoriumintybus L. are the seeds of Compositae Cichorium glandulosum Boiss.et Huet. It has the effects of clearing the liver and gallbladder, invigorating the stomach and eliminating food, diuresis and swelling. It is used for damp-heat jaundice, stomach pain, lack of foo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P3/10A23L1/30A61K131/00A23L33/10
Inventor 阿吉艾克拜尔·艾萨吴汉夔信学雷阿不力米提·伊力巴杭
Owner 新疆新绿宝药业有限公司
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