Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar

A technology of pentacyclic triterpene saponins and compounds, which is applied in the field of new medical applications of pentacyclic triterpene saponins compounds in tilegrass, can solve the problems of few pharmacological research reports, achieve unique and novel structure, obvious hypoglycemic effect, and less pollution Effect

Active Publication Date: 2014-02-26
王学勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the researches on wacao mainly focus on the research on the chemical constituents, and there are few reports on the pharmacological aspects.

Method used

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  • Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar
  • Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar
  • Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0071] Extraction, separation, purification and identification method of the pentacyclic triterpenoids of experimental example 1

[0072] Take 21kg of tile grass, grind it and extract three times with 170L of 95% ethanol and 70% ethanol respectively, concentrate to get 7kg of extract, refer to the literature for the separation and purification method (J. Zhao, Norio Nakamura, Masao Hattori. New triterpenoid saponins from the roots of sinocrassuloasclepiadea[J].Pharmaceutical Society of Japan, 2004,52(2):230-237.) to obtain macromolecular compounds sinocrassuloside VI, sinocrassuloside VII, sinocrassuloside VIII, sinocrassuloside IX, sinocrassuloside XII, sinocrassuloside XIII, wherein VI, sinocrassuloside XIII Sinocrassuloside Ⅶ, sinocrassuloside Ⅷ and sinocrassuloside Ⅸ, sinocrassuloside Ⅻ and sinocrassuloside Ⅹ are 3 pairs of cis-trans isomers.

[0073] Compound 1 and compound 2 (sinocrassuloside Ⅵ and sinocrassuloside Ⅶ): white powder, molecular formula: C 71 h 102 o 31 ...

experiment example 2

[0078] Experimental Example 2 Hypoglycemic Effect of Pentacyclic Triterpene Saponins Compounds in Type 2 Diabetic Mice

[0079] Animal and Breeding Management

[0080] 12-week-old male KK Ay 80 mice, 10 12-week-old male C57BL / 6 mice, provided by Beijing Huafukang Biotechnology Co., Ltd., license number SCXK (Beijing) 2009-0015, the mice were adaptively fed for 1 week for drug efficacy learning experiment.

[0081] The feeding conditions of the experimental animals are shown in Table 2:

[0082] Table 2 Experimental Animal Feeding Conditions

[0083] temperature

22℃±2℃

lighting

12 hours light / 12 hours dark

[0084] 12 hours of light / 12 hours of darkness: Indicates that the alternating time of light and dark is 12 hours each.

[0085] Animals are housed in plastic terrariums with bedding, clean grade KK Ay They were fed with special high-fat feed (purchased from Beijing Huafukang Biotechnology Co., Ltd.), and had free access to water.

[...

experiment example 3

[0110] Experimental Example 3 Therapeutic Effects of Pentacyclic Triterpene Saponins Compounds on Type 2 Diabetic Mice

[0111] Animal and Breeding Management

[0112] 12-week-old male KK Ay 60 mice, 10 12-week-old male C57BL / 6 mice (provided by Beijing Huafukang Biotechnology Co., Ltd., license number SCXK (Beijing) 2009-0015), were used for pharmacodynamics after 1 week of adaptive feeding experiment.

[0113] The experimental animal feeding conditions are shown in Table 4:

[0114] Table 4 Experimental Animal Feeding Conditions

[0115] temperature

22℃±2℃

lighting

12 hours light / 12 hours dark

[0116] 12 hours of light / 12 hours of darkness: Indicates that the alternating time of light and dark is 12 hours each.

[0117] Animals are housed in plastic terrariums with bedding, clean grade KK Ay They were fed with special high-fat feed (purchased from Beijing Huafukang Biotechnology Co., Ltd.), and had free access to water.

[0118] experi...

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Abstract

The invention relates to a use of a szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of a drug for reducing blood sugar. Through massive screening and research, the inventor first finds the szechuan melandium root pentacyclic triterpenoid saponin compound extracted from a caryophyllaceae plant szechuan melandium root, purifies it and especially finds that a composition of a compound with sinocrassuloside as a mother nucleus and the szechuan melandium root pentacyclic triterpenoid saponin compound has strong blood sugar-reduction effects and can be used for preparation of anti-diabetic drugs.

Description

technical field [0001] The present invention relates to the application of the vacao pentacyclic triterpene saponins to prepare hypoglycemic drugs, and belongs to the field of new medical applications of the vacao pentacyclic triterpene saponins. Background technique [0002] Diabetes mellitus is a disease caused by a disorder of glucose metabolism characterized by elevated plasma glucose levels and hyperglycemia after administration of glucose in a fasting state or during an oral glucose tolerance test. Diabetes is mainly divided into two types, namely type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) and type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM). In type 1 diabetes patients, the amount of insulin produced in the body decreases, or even does not produce insulin. Insulin is mainly responsible for regulating the utilization of glucose in the body, and its production decreases to increase blood sugar. Type 2 diabetes is mainly related to facto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P3/10
CPCA61K31/704A61P3/10
Inventor 王学勇赵保胜
Owner 王学勇
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