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Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar

一种五环三萜皂苷、化合物的技术，应用在瓦草五环三萜皂苷类化合物医药新用途领域，能够解决药理方面研究报道少等问题，达到结构独特新颖、作用强、降糖效果明显的效果

Active Publication Date: 2015-04-22
王学勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the researches on wacao mainly focus on the research on the chemical constituents, and there are few reports on the pharmacological aspects.

Method used

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  • Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar
  • Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar
  • Use of szechuan melandium root pentacyclic triterpenoid saponin compound in preparation of drug for reducing blood sugar

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0071] Extraction, separation, purification and identification method of the pentacyclic triterpenoids of experimental example 1

[0072] Take 21kg of tile grass, grind it and extract three times with 170L of 95% ethanol and 70% ethanol respectively, concentrate to get 7kg of extract, refer to the literature for the separation and purification method (J. Zhao, Norio Nakamura, Masao Hattori. New triterpenoid saponins from the roots of sinocrassulaasclepiadea[J].Pharmaceutical Society of Japan,2004,52(2):230-237.)得到大分子化合物sinocrassulosideⅥ、sinocrassulosideⅦ、sinocrassulosideⅧ、sinocrassulosideⅨ、sinocrassulosideⅫ、sinocrassulosideⅩⅢ,其中,sinocrassuloside Ⅵ和sinocrassulosideⅦ,sinocrassulosideⅧ和sinocrassulosideⅨ, SinocrassulosideⅫ and sinocrassulosideⅩⅢ are 3 pairs of cis-trans isomers.

[0073] Compound 1 and compound 2 (sinocrassuloside VI and sinocrassuloside VII): white powder, molecular formula: C 71 h 102 o 31 . ESI-MS (m / z): 1473.2[M+Na]+, 1449.7[M-H] - . 1 H-NMR and 13 The ...

experiment example 2

[0079] Experimental Example 2 Hypoglycemic Effect of Pentacyclic Triterpene Saponins Compounds in Type 2 Diabetic Mice

[0080] Animal and Breeding Management

[0081] 12-week-old male KK Ay 80 mice, 10 12-week-old male C57BL / 6 mice, provided by Beijing Huafukang Biotechnology Co., Ltd., license number SCXK (Beijing) 2009-0015, the mice were adaptively fed for 1 week for drug efficacy learning experiment.

[0082] The feeding conditions of the experimental animals are shown in Table 2:

[0083] Table 2 Experimental Animal Feeding Conditions

[0084] temperature

22℃±2℃

lighting

12 hours light / 12 hours dark

[0085] 12 hours of light / 12 hours of darkness: Indicates that the alternating time of light and dark is 12 hours each.

[0086] Animals are housed in plastic terrariums with bedding, clean grade KK Ay They were fed with special high-fat feed (purchased from Beijing Huafukang Biotechnology Co., Ltd.), and had free access to water.

[00...

experiment example 3

[0111] Experimental Example 3 Therapeutic Effects of Pentacyclic Triterpene Saponins Compounds on Type 2 Diabetic Mice

[0112] Animal and Breeding Management

[0113] 12-week-old male KK Ay 60 mice, 10 12-week-old male C57BL / 6 mice (provided by Beijing Huafukang Biotechnology Co., Ltd., license number SCXK (Beijing) 2009-0015), were used for pharmacodynamics after 1 week of adaptive feeding experiment.

[0114] The experimental animal feeding conditions are shown in Table 4:

[0115] Table 4 Experimental Animal Feeding Conditions

[0116] temperature

22℃±2℃

lighting

12 hours light / 12 hours dark

[0117] 12 hours of light / 12 hours of darkness: Indicates that the alternating time of light and dark is 12 hours each.

[0118] Animals are housed in plastic terrariums with bedding, clean grade KK Ay They were fed with special high-fat feed (purchased from Beijing Huafukang Biotechnology Co., Ltd.), and had free access to water.

[0119] experi...

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PUM

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Abstract

The invention relates to the application of pentacyclic triterpenoid saponins, extracted from the plant of Silene viscidula, which are used to manufacture the anti-diabetic medicaments. Having screened and researched the plants and the compounds massively, the inventors found that the compounds of pentacyclic triterpenoid saponins extracted and purified from Silene viscidula (hereinafter called Wacao saponnins), have strong effects on hyperglycemia, especially for the compounds that have mother nuclei of sinocrassulosides, which can be used to manufacture anti-diabetic medicaments.

Description

technical field [0001] The present invention relates to the application of the vacao pentacyclic triterpene saponins to prepare hypoglycemic drugs, and belongs to the field of new medical applications of the vacao pentacyclic triterpene saponins. Background technique [0002] Diabetes mellitus is a disease caused by a disorder of glucose metabolism characterized by elevated plasma glucose levels and hyperglycemia after administration of glucose in a fasting state or during an oral glucose tolerance test. Diabetes is mainly divided into two types, namely type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) and type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM). In type 1 diabetes patients, the amount of insulin produced in the body decreases, or even does not produce insulin. Insulin is mainly responsible for regulating the utilization of glucose in the body, and its production decreases to increase blood sugar. Type 2 diabetes is mainly related to facto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P3/10
CPCA61K31/704A61P3/10
Inventor 王学勇赵保胜
Owner 王学勇
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